Motif ID: Klf4_Sp3

Z-value: 1.266

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf4mm10_v2_chr4_-_55532453_55532485-0.583.0e-02Click!
Sp3mm10_v2_chr2_-_72980402_72980471-0.391.6e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_95587691 4.132 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr6_-_72958097 3.367 ENSMUST00000114049.1
 Tmsb10
thymosin, beta 10
chr7_+_29289300 3.112 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr13_-_41079628 3.110 ENSMUST00000165087.1
ENSMUST00000070193.6
 Mak

male germ cell-associated kinase

chr11_+_119942763 3.004 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr8_-_87472365 3.002 ENSMUST00000169693.1
 Cbln1
cerebellin 1 precursor protein
chr4_+_47353283 2.902 ENSMUST00000044234.7
 Tgfbr1
transforming growth factor, beta receptor I
chr8_-_87472576 2.756 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr15_-_66969616 2.633 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_+_5725639 2.566 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr14_-_30626196 2.565 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr7_+_45163915 2.532 ENSMUST00000085374.5
 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr3_+_121953213 2.526 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr4_-_142239356 2.488 ENSMUST00000036476.3
 Kazn
kazrin, periplakin interacting protein
chr1_+_89070406 2.457 ENSMUST00000066279.4
 Sh3bp4
SH3-domain binding protein 4
chr15_-_60824942 2.413 ENSMUST00000100635.3
 Fam84b
family with sequence similarity 84, member B
chr10_-_127534540 2.398 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr6_-_72958465 2.391 ENSMUST00000114050.1
 Tmsb10
thymosin, beta 10
chr6_+_51432663 2.353 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr6_-_52012476 2.321 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,018 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.4 6.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.4 5.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.9 5.2 GO:0060017 parathyroid gland development(GO:0060017)
1.0 4.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.1 4.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 4.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.6 4.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.4 4.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.2 4.2 GO:0050832 defense response to fungus(GO:0050832)
0.8 3.9 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.3 3.7 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 3.6 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.4 3.5 GO:0006477 protein sulfation(GO:0006477)
0.2 3.5 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406)
0.1 3.5 GO:0007020 microtubule nucleation(GO:0007020)
0.7 3.4 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.7 3.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.5 3.4 GO:0001842 neural fold formation(GO:0001842)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 376 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 45.5 GO:0005739 mitochondrion(GO:0005739)
0.2 6.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 6.4 GO:0071565 nBAF complex(GO:0071565)
0.0 6.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 5.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.4 GO:0097060 synaptic membrane(GO:0097060)
0.1 5.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 4.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 4.8 GO:0005776 autophagosome(GO:0005776)
0.1 4.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 4.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 4.4 GO:0043196 varicosity(GO:0043196)
0.1 4.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 4.1 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.9 GO:0005643 nuclear pore(GO:0005643)
0.1 3.7 GO:0070469 respiratory chain(GO:0070469)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.1 3.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 590 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 10.1 GO:0030165 PDZ domain binding(GO:0030165)
0.3 7.8 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.8 6.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 6.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 6.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 6.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 6.0 GO:0003785 actin monomer binding(GO:0003785)
0.6 5.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 5.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 5.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.0 4.8 GO:0045503 dynein light chain binding(GO:0045503)
0.5 4.6 GO:0048406 nerve growth factor binding(GO:0048406)
1.1 4.5 GO:0070976 TIR domain binding(GO:0070976)
0.2 4.4 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 4.2 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.5 4.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.2 3.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)