Motif ID: Mafa

Z-value: 1.190


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_757479220.185.4e-01Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_102254739 3.862 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 3.126 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_42035113 2.036 ENSMUST00000098127.1
 Gm10597
predicted gene 10597
chr11_-_66525964 1.982 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr4_+_21931291 1.790 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr9_-_98032983 1.748 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr9_-_48835932 1.722 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr1_-_169747634 1.700 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chrX_+_104482774 1.630 ENSMUST00000087867.5
 Uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr12_-_75177325 1.606 ENSMUST00000042299.2
 Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chrX_-_73869804 1.556 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr4_-_35845204 1.541 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr14_+_119138415 1.493 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr7_-_67759735 1.449 ENSMUST00000074233.4
ENSMUST00000051389.8
 Synm

synemin, intermediate filament protein

chr9_-_51077064 1.347 ENSMUST00000098782.3
 Layn
layilin
chr11_-_107337556 1.157 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr8_+_105373265 1.125 ENSMUST00000160650.1
 Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr16_-_74411776 1.107 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr9_-_45906837 1.000 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr17_-_72603709 0.983 ENSMUST00000086639.4
 Alk
anaplastic lymphoma kinase
chr4_+_155601854 0.965 ENSMUST00000118607.1
 Slc35e2
solute carrier family 35, member E2
chr16_-_74411292 0.881 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_17576631 0.872 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr11_+_119229092 0.814 ENSMUST00000053440.7
 Ccdc40
coiled-coil domain containing 40
chr11_-_66525795 0.763 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chrX_-_95444789 0.757 ENSMUST00000084535.5
 Amer1
APC membrane recruitment 1
chr10_-_84440591 0.747 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr5_+_124629050 0.739 ENSMUST00000037865.8
 Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
chrX_-_97377150 0.717 ENSMUST00000113832.1
 Eda2r
ectodysplasin A2 receptor
chr9_-_65580040 0.704 ENSMUST00000068944.7
 Plekho2
pleckstrin homology domain containing, family O member 2
chr1_-_136260873 0.698 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chrX_-_93832106 0.659 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr16_+_20651652 0.619 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr5_-_142509653 0.586 ENSMUST00000110784.1
 Radil
Ras association and DIL domains
chr12_+_3365108 0.580 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr17_-_23844155 0.579 ENSMUST00000122936.1
ENSMUST00000024926.7
ENSMUST00000151797.1
 Prss41


protease, serine, 41


chr2_-_125506385 0.571 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr11_-_119228461 0.535 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr12_+_105453831 0.515 ENSMUST00000178224.1
 D430019H16Rik
RIKEN cDNA D430019H16 gene
chr9_-_98033181 0.507 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr13_+_4233730 0.503 ENSMUST00000081326.6
 Akr1c19
aldo-keto reductase family 1, member C19
chr5_+_24423805 0.491 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr1_-_38836090 0.490 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr1_-_121327776 0.436 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr18_-_53744509 0.411 ENSMUST00000049811.6
 Cep120
centrosomal protein 120
chr11_-_73138245 0.379 ENSMUST00000052140.2
 Gsg2
germ cell-specific gene 2
chr18_-_36197343 0.375 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr12_+_53248677 0.357 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr17_-_47010513 0.357 ENSMUST00000113337.2
ENSMUST00000113335.2
 Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr4_+_155601414 0.354 ENSMUST00000105608.2
 Slc35e2
solute carrier family 35, member E2
chr19_+_27217011 0.351 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr17_-_47611449 0.334 ENSMUST00000024783.8
 Bysl
bystin-like
chr13_+_24943144 0.313 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr19_+_27217357 0.307 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr4_-_59138983 0.295 ENSMUST00000107547.1
 AI481877
expressed sequence AI481877
chr12_-_86884808 0.290 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr11_+_87595646 0.283 ENSMUST00000134216.1
 Mtmr4
myotubularin related protein 4
chr2_-_166155272 0.283 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chrX_+_152178945 0.263 ENSMUST00000096275.4
 Iqsec2
IQ motif and Sec7 domain 2
chr18_-_42579652 0.261 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr1_-_105356658 0.258 ENSMUST00000058688.5
ENSMUST00000172299.1
 Rnf152

ring finger protein 152

chr5_-_124187150 0.238 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr1_-_121327672 0.237 ENSMUST00000159085.1
ENSMUST00000159125.1
ENSMUST00000161818.1
 Insig2


insulin induced gene 2


chr5_+_111417263 0.219 ENSMUST00000094463.4
 Mn1
meningioma 1
chr8_+_93810832 0.205 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr6_-_54566484 0.203 ENSMUST00000019268.4
 Scrn1
secernin 1
chrX_-_20950597 0.190 ENSMUST00000009550.7
 Elk1
ELK1, member of ETS oncogene family
chr1_-_121327734 0.175 ENSMUST00000160968.1
ENSMUST00000162582.1
 Insig2

insulin induced gene 2

chr11_+_98927785 0.175 ENSMUST00000107474.1
 Rara
retinoic acid receptor, alpha
chr13_+_93771656 0.171 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr13_+_96924674 0.165 ENSMUST00000171324.1
 Gcnt4
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
chr4_+_139233383 0.132 ENSMUST00000042675.7
 Capzb
capping protein (actin filament) muscle Z-line, beta
chr6_+_65381294 0.123 ENSMUST00000170608.1
 C130060K24Rik
RIKEN cDNA C130060K24 gene
chr17_+_47611570 0.114 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr17_-_71475285 0.101 ENSMUST00000127430.1
 Smchd1
SMC hinge domain containing 1
chr16_+_22009471 0.081 ENSMUST00000023561.7
 Senp2
SUMO/sentrin specific peptidase 2
chr1_+_87183310 0.079 ENSMUST00000044533.8
 Prss56
protease, serine 56
chr1_+_171213969 0.073 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr4_+_43406435 0.072 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr4_-_58912678 0.044 ENSMUST00000144512.1
ENSMUST00000102889.3
ENSMUST00000055822.8
 AI314180


expressed sequence AI314180


chr10_+_58813359 0.043 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr7_+_140856957 0.042 ENSMUST00000026558.6
 Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chrX_-_97377190 0.030 ENSMUST00000037353.3
 Eda2r
ectodysplasin A2 receptor
chr7_+_128237357 0.029 ENSMUST00000044660.5
 Armc5
armadillo repeat containing 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 1.6 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.5 7.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.7 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.3 1.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.6 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.2 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.2 2.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.7 GO:0034436 glycoprotein transport(GO:0034436)
0.1 0.4 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.8 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.4 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.3 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.7 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 1.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 3.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.0 0.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.4 GO:0042711 maternal behavior(GO:0042711)
0.0 0.1 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 1.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 2.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.0 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.6 GO:0001527 microfibril(GO:0001527)
0.0 1.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0004849 uridine kinase activity(GO:0004849)
0.3 1.6 GO:0033691 sialic acid binding(GO:0033691)
0.3 1.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 2.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.7 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.2 0.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 7.0 GO:0030552 cAMP binding(GO:0030552)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.4 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.0 0.4 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 1.5 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.9 GO:0015297 antiporter activity(GO:0015297)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)