Motif ID: Nkx3-1

Z-value: 0.855


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_124493793 1.962 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr1_+_99772765 1.597 ENSMUST00000086738.3
 Cntnap5b
contactin associated protein-like 5B
chr4_-_15149755 1.416 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr6_+_58833689 1.348 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3
chr6_-_99632376 1.348 ENSMUST00000176255.1
 Gm20696
predicted gene 20696
chr8_+_36457548 1.152 ENSMUST00000135373.1
ENSMUST00000147525.1
 6430573F11Rik

RIKEN cDNA 6430573F11 gene

chr2_+_23069210 0.980 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr5_+_21424934 0.911 ENSMUST00000056045.4
 Fam185a
family with sequence similarity 185, member A
chr13_+_109632760 0.897 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr5_+_37185897 0.855 ENSMUST00000094840.3
 Gm1043
predicted gene 1043
chrX_-_75875101 0.788 ENSMUST00000114059.3
 Pls3
plastin 3 (T-isoform)
chrX_-_75874536 0.771 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr1_+_161142661 0.754 ENSMUST00000125018.1
 Ankrd45
ankyrin repeat domain 45
chr3_-_127408937 0.739 ENSMUST00000183095.1
ENSMUST00000182610.1
 Ank2

ankyrin 2, brain

chr1_+_161142706 0.716 ENSMUST00000111608.1
ENSMUST00000052245.8
 Ankrd45

ankyrin repeat domain 45

chr18_-_6241470 0.701 ENSMUST00000163210.1
 Kif5b
kinesin family member 5B
chr3_-_127409014 0.684 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
 Ank2


ankyrin 2, brain


chr5_-_110046486 0.665 ENSMUST00000167969.1
 Gm17655
predicted gene, 17655
chr19_+_43689672 0.643 ENSMUST00000081079.5
 Entpd7
ectonucleoside triphosphate diphosphohydrolase 7
chr12_-_87233556 0.632 ENSMUST00000021423.7
 Noxred1
NADP+ dependent oxidoreductase domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.3 GO:0035617 stress granule disassembly(GO:0035617)
0.3 1.3 GO:0030242 pexophagy(GO:0030242)
0.1 0.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739) amylase secretion(GO:0036394)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 0.6 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.6 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.6 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.6 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 0.6 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.6 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.2 0.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 0.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.5 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.5 GO:0015858 nucleoside transport(GO:0015858)
0.1 0.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.4 GO:0036337 Fas signaling pathway(GO:0036337)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0031430 M band(GO:0031430)
0.0 1.6 GO:0032420 stereocilium(GO:0032420)
0.1 1.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0005712 chiasma(GO:0005712)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.3 GO:0036038 gamma-tubulin complex(GO:0000930) MKS complex(GO:0036038)
0.1 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.2 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.1 GO:0097342 ripoptosome(GO:0097342)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0070938 contractile ring(GO:0070938)
0.0 0.0 GO:0097447 dendritic tree(GO:0097447)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.8 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.1 0.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.6 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 0.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.1 0.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)