Motif ID: Nkx3-2

Z-value: 0.844


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_123267445 1.506 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr4_+_102421518 1.425 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_-_103853199 1.319 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr6_-_138421379 1.271 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr15_-_45114926 1.203 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr19_+_8740712 0.926 ENSMUST00000163172.1
 1700092M07Rik
RIKEN cDNA 1700092M07 gene
chr2_-_54085542 0.886 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr15_-_66969616 0.790 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr1_-_158958367 0.747 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr6_-_92534855 0.659 ENSMUST00000113446.1
 Prickle2
prickle homolog 2 (Drosophila)
chr6_+_96115249 0.658 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr2_-_118549668 0.641 ENSMUST00000090219.6
 Bmf
BCL2 modifying factor
chr11_+_120949053 0.617 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr19_-_34255325 0.542 ENSMUST00000039631.8
 Acta2
actin, alpha 2, smooth muscle, aorta
chr4_-_119173849 0.541 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr17_-_34627365 0.521 ENSMUST00000064953.8
ENSMUST00000170345.1
ENSMUST00000171121.2
ENSMUST00000168391.2
ENSMUST00000169067.2
 Ppt2




palmitoyl-protein thioesterase 2




chr17_-_45686899 0.519 ENSMUST00000156254.1
 Tmem63b
transmembrane protein 63b
chr2_+_35691893 0.512 ENSMUST00000065001.5
 Dab2ip
disabled 2 interacting protein
chr8_-_122678072 0.500 ENSMUST00000006525.7
ENSMUST00000064674.6
 Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

chr8_-_84067283 0.490 ENSMUST00000071067.3
 C330011M18Rik
RIKEN cDNA C330011M18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.3 GO:0015671 oxygen transport(GO:0015671)
0.0 1.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.9 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.9 GO:0060349 bone morphogenesis(GO:0060349)
0.2 0.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 0.8 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
0.1 0.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 0.7 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.6 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.2 0.5 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.1 0.5 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 0.5 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.1 0.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.5 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 0.5 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.5 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.5 GO:2000193 positive regulation of fatty acid transport(GO:2000193)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)
0.2 0.5 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.5 GO:1990032 parallel fiber(GO:1990032)
0.1 0.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.4 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 1.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 1.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0030332 cyclin binding(GO:0030332)
0.0 0.6 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.1 0.5 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.4 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)