Motif ID: En1

Z-value: 0.751


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.441.1e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_90772435 2.055 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr2_+_14229390 1.700 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr12_-_119238794 1.435 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr7_-_112159034 1.429 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr16_-_43979050 1.263 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr3_+_141465564 0.946 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr3_+_62419668 0.880 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_+_141465592 0.849 ENSMUST00000130636.1
 Unc5c
unc-5 homolog C (C. elegans)
chr11_-_83649349 0.836 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr11_-_81968415 0.824 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr3_-_132950043 0.787 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
 Npnt




nephronectin




chr1_-_87156127 0.774 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr2_+_155940728 0.752 ENSMUST00000109629.1
 Gm15557
predicted gene 15557
chr11_+_97685794 0.737 ENSMUST00000107584.1
ENSMUST00000107585.2
 Cisd3

CDGSH iron sulfur domain 3

chr16_-_26371828 0.729 ENSMUST00000023154.2
 Cldn1
claudin 1
chr7_-_57509995 0.721 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chrX_+_56374550 0.716 ENSMUST00000068106.3
 6330419J24Rik
RIKEN cDNA 6330419J24 gene
chr10_+_62071014 0.681 ENSMUST00000053865.5
 Gm5424
predicted gene 5424
chr8_+_82863351 0.666 ENSMUST00000078525.5
 Rnf150
ring finger protein 150
chr18_+_69593361 0.662 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 1.9 GO:0001573 ganglioside metabolic process(GO:0001573)
0.2 1.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 1.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 1.4 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.2 1.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 0.8 GO:0050915 sensory perception of sour taste(GO:0050915)
0.3 0.8 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.1 0.8 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.1 0.8 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.8 GO:0003016 respiratory system process(GO:0003016)
0.1 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0001504 neurotransmitter uptake(GO:0001504)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.3 GO:0036128 CatSper complex(GO:0036128)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.8 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.2 1.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 0.8 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.4 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.4 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)