Motif ID: E2f7

Z-value: 1.242


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_110745572-0.156.2e-01Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3013140 8.723 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 7.913 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 6.894 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 5.947 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 5.907 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr7_-_142578139 1.168 ENSMUST00000136359.1
 H19
H19 fetal liver mRNA
chr8_+_72319033 1.145 ENSMUST00000067912.7
 Klf2
Kruppel-like factor 2 (lung)
chr1_-_191183244 1.117 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr7_+_35802593 0.967 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr3_-_144202300 0.941 ENSMUST00000121796.1
ENSMUST00000121112.1
 Lmo4

LIM domain only 4

chr19_-_10881677 0.682 ENSMUST00000128835.1
 Tmem109
transmembrane protein 109
chr5_+_130448801 0.603 ENSMUST00000111288.2
 Caln1
calneuron 1
chr10_+_91082940 0.546 ENSMUST00000020150.3
 Ikbip
IKBKB interacting protein
chr3_+_60501252 0.496 ENSMUST00000099087.2
 Mbnl1
muscleblind-like 1 (Drosophila)
chr7_+_44816364 0.432 ENSMUST00000118125.1
 Il4i1
interleukin 4 induced 1
chr2_+_18672384 0.428 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3

chr15_+_79030874 0.420 ENSMUST00000171999.1
ENSMUST00000006544.7
 Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

chr12_+_11265867 0.416 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr19_-_10881723 0.394 ENSMUST00000144681.1
 Tmem109
transmembrane protein 109
chr17_-_35516780 0.392 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr10_-_69352886 0.389 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr1_-_128359610 0.378 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr7_-_116308241 0.369 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr13_-_97198351 0.366 ENSMUST00000022169.7
 Hexb
hexosaminidase B
chr10_-_35711891 0.362 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr4_+_132768325 0.361 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr1_+_86526688 0.350 ENSMUST00000045897.8
 Ptma
prothymosin alpha
chr13_-_21783391 0.333 ENSMUST00000099704.3
 Hist1h3i
histone cluster 1, H3i
chr4_+_94739276 0.327 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chr1_-_88702121 0.323 ENSMUST00000159814.1
 Arl4c
ADP-ribosylation factor-like 4C
chr19_-_7217549 0.314 ENSMUST00000039758.4
 Cox8a
cytochrome c oxidase subunit VIIIa
chr19_+_34550664 0.312 ENSMUST00000149829.1
ENSMUST00000102826.3
 Ifit2

interferon-induced protein with tetratricopeptide repeats 2

chr3_-_107943705 0.305 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
 Gstm6


glutathione S-transferase, mu 6


chr11_-_77513335 0.299 ENSMUST00000060417.4
 Trp53i13
transformation related protein 53 inducible protein 13
chr4_+_95967322 0.279 ENSMUST00000107083.1
 Hook1
hook homolog 1 (Drosophila)
chr5_-_24447587 0.267 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
 Tmub1



transmembrane and ubiquitin-like domain containing 1



chr12_-_11265768 0.257 ENSMUST00000166117.1
 Gen1
Gen homolog 1, endonuclease (Drosophila)
chr17_-_25792284 0.257 ENSMUST00000072735.7
 Fam173a
family with sequence similarity 173, member A
chr1_-_180813591 0.248 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr15_-_33687840 0.224 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr8_+_75109528 0.224 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chrX_+_162760388 0.224 ENSMUST00000033720.5
ENSMUST00000112327.1
 Rbbp7

retinoblastoma binding protein 7

chr14_+_4726775 0.224 ENSMUST00000165619.1
 Gm3252
predicted gene 3252
chr13_-_22035589 0.222 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr9_-_121277160 0.217 ENSMUST00000051479.6
ENSMUST00000171923.1
 Ulk4

unc-51-like kinase 4

chr17_+_35517100 0.216 ENSMUST00000164242.2
ENSMUST00000045956.7
 Cchcr1

coiled-coil alpha-helical rod protein 1

chr14_-_54253907 0.214 ENSMUST00000128231.1
 Dad1
defender against cell death 1
chr6_+_15721087 0.203 ENSMUST00000120512.1
 Mdfic
MyoD family inhibitor domain containing
chr16_+_38346986 0.197 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
 Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr13_-_22042949 0.186 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr4_-_108579330 0.182 ENSMUST00000079213.5
 Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr8_+_25518757 0.180 ENSMUST00000178276.1
ENSMUST00000179592.1
 Fgfr1

fibroblast growth factor receptor 1

chr8_+_25518783 0.174 ENSMUST00000084027.5
ENSMUST00000117179.2
 Fgfr1

fibroblast growth factor receptor 1

chr13_-_55329723 0.169 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr14_+_4182576 0.154 ENSMUST00000164512.1
 Gm2974
predicted gene 2974
chr7_-_98656530 0.150 ENSMUST00000038359.4
 2210018M11Rik
RIKEN cDNA 2210018M11 gene
chrX_-_7375830 0.143 ENSMUST00000115744.1
 Usp27x
ubiquitin specific peptidase 27, X chromosome
chr2_-_36104060 0.141 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr5_-_137533170 0.141 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr14_-_20388822 0.140 ENSMUST00000022345.6
 Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr10_-_128409632 0.139 ENSMUST00000172348.1
ENSMUST00000166608.1
ENSMUST00000164199.1
ENSMUST00000171370.1
ENSMUST00000026439.7
 Nabp2




nucleic acid binding protein 2




chr7_-_109752210 0.139 ENSMUST00000128043.1
ENSMUST00000033333.6
 Tmem9b

TMEM9 domain family, member B

chr12_-_73286698 0.135 ENSMUST00000116420.2
 Trmt5
TRM5 tRNA methyltransferase 5
chr12_+_73286868 0.135 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
 Slc38a6


solute carrier family 38, member 6


chr4_+_108579445 0.131 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr1_+_172521044 0.131 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
 Ccdc19


coiled-coil domain containing 19


chr11_-_74897052 0.130 ENSMUST00000057631.5
ENSMUST00000081799.5
 Sgsm2

small G protein signaling modulator 2

chrX_+_153006461 0.130 ENSMUST00000095755.3
 Usp51
ubiquitin specific protease 51
chr4_+_108459389 0.130 ENSMUST00000106673.1
ENSMUST00000043368.5
 Zcchc11

zinc finger, CCHC domain containing 11

chr9_+_44334685 0.129 ENSMUST00000052686.2
 H2afx
H2A histone family, member X
chr17_-_35121990 0.123 ENSMUST00000173915.1
ENSMUST00000172765.2
 Csnk2b

casein kinase 2, beta polypeptide

chr13_+_21754067 0.123 ENSMUST00000091709.2
 Hist1h2bn
histone cluster 1, H2bn
chr7_+_44816088 0.123 ENSMUST00000057195.9
ENSMUST00000107891.1
 Nup62

nucleoporin 62

chr3_-_57847478 0.117 ENSMUST00000120289.1
ENSMUST00000066882.8
 Pfn2

profilin 2

chr5_+_129020069 0.115 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr14_+_4334763 0.114 ENSMUST00000165466.1
 2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr2_-_157204483 0.112 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chrX_-_37085402 0.106 ENSMUST00000115231.3
 Rpl39
ribosomal protein L39
chr14_-_6038209 0.092 ENSMUST00000164139.1
 Gm8206
predicted gene 8206
chr10_+_19934472 0.088 ENSMUST00000095806.3
ENSMUST00000120259.1
 Map3k5

mitogen-activated protein kinase kinase kinase 5

chr8_+_72161101 0.076 ENSMUST00000003121.8
 Rab8a
RAB8A, member RAS oncogene family
chr2_+_112261926 0.076 ENSMUST00000028553.3
 Nop10
NOP10 ribonucleoprotein
chr13_-_21833575 0.073 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr7_-_120202104 0.072 ENSMUST00000033198.5
 Crym
crystallin, mu
chr15_-_81871883 0.071 ENSMUST00000023117.8
 Phf5a
PHD finger protein 5A
chr11_-_69560186 0.067 ENSMUST00000004036.5
 Efnb3
ephrin B3
chr9_+_64281575 0.063 ENSMUST00000034964.6
 Tipin
timeless interacting protein
chr11_-_61762040 0.055 ENSMUST00000004955.7
ENSMUST00000168115.1
 Prpsap2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr12_+_55836365 0.055 ENSMUST00000059250.6
 Brms1l
breast cancer metastasis-suppressor 1-like
chr14_+_3572023 0.045 ENSMUST00000178728.1
 Gm3005
predicted gene 3005
chr17_+_25773769 0.045 ENSMUST00000134108.1
ENSMUST00000002350.4
 Narfl

nuclear prelamin A recognition factor-like

chr14_+_5071040 0.043 ENSMUST00000163719.1
 Gm8281
predicted gene, 8281
chr10_+_91083036 0.042 ENSMUST00000020149.5
 Ikbip
IKBKB interacting protein
chr15_+_98092569 0.041 ENSMUST00000163507.1
 Pfkm
phosphofructokinase, muscle
chr10_-_117376955 0.040 ENSMUST00000069168.6
ENSMUST00000176686.1
 Cpsf6

cleavage and polyadenylation specific factor 6

chr7_-_44816586 0.029 ENSMUST00000047356.8
 Atf5
activating transcription factor 5
chr14_-_54877532 0.028 ENSMUST00000168622.1
ENSMUST00000177403.1
 Ppp1r3e

protein phosphatase 1, regulatory (inhibitor) subunit 3E

chr15_-_98093245 0.025 ENSMUST00000180657.1
 Senp1
SUMO1/sentrin specific peptidase 1
chr11_-_101466222 0.022 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr7_-_28598140 0.014 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr14_+_54254124 0.011 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr9_+_44084944 0.009 ENSMUST00000176416.1
ENSMUST00000065461.7
 Usp2

ubiquitin specific peptidase 2

chr17_-_35046726 0.008 ENSMUST00000097338.4
 Msh5
mutS homolog 5 (E. coli)
chr13_+_22035821 0.007 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr14_+_4855576 0.005 ENSMUST00000166776.1
 Gm3264
predicted gene 3264
chr19_-_4698315 0.004 ENSMUST00000096325.3
 Gm960
predicted gene 960

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 1.1 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.2 0.7 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.1 0.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.4 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 0.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.2 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.1 GO:0060025 regulation of synaptic activity(GO:0060025)
0.0 0.4 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.1 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 1.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.4 GO:0019808 polyamine binding(GO:0019808)
0.1 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0070883 importin-alpha family protein binding(GO:0061676) pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)