Motif ID: Tcf4_Mesp1

Z-value: 1.357

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69344503_69344530-0.669.6e-03Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_123982799 4.847 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr13_-_57907587 4.801 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr15_-_66831625 4.501 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_-_67922136 4.412 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr4_+_125490688 4.090 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr2_-_57114970 3.933 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr19_-_41743665 3.903 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr16_+_11984581 3.349 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr2_-_65022740 3.277 ENSMUST00000028252.7
 Grb14
growth factor receptor bound protein 14
chr5_+_98854434 3.275 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr8_+_83389878 3.102 ENSMUST00000109831.2
 Clgn
calmegin
chr11_-_7213897 3.056 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr8_+_83389846 2.855 ENSMUST00000002259.6
 Clgn
calmegin
chr3_+_75557530 2.823 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr13_+_16011851 2.649 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr4_+_102087543 2.599 ENSMUST00000106911.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr16_-_16869255 2.585 ENSMUST00000075017.4
 Vpreb1
pre-B lymphocyte gene 1
chr19_-_57314896 2.581 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr6_-_92706145 2.568 ENSMUST00000032093.5
 Prickle2
prickle homolog 2 (Drosophila)
chr16_+_78930940 2.541 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 486 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0048193 Golgi vesicle transport(GO:0048193)
0.1 5.1 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.2 5.0 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.1 4.9 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 4.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 4.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.3 4.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 4.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.0 3.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.6 3.9 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 3.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.5 3.8 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.4 3.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.4 3.3 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 3.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 3.2 GO:0043171 peptide catabolic process(GO:0043171)
0.7 3.0 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.5 2.7 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.4 2.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.9 2.6 GO:0001830 trophectodermal cell fate commitment(GO:0001830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 6.2 GO:0005635 nuclear envelope(GO:0005635)
0.2 4.8 GO:0033268 node of Ranvier(GO:0033268)
0.1 4.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.7 GO:0043195 terminal bouton(GO:0043195)
0.2 4.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 4.1 GO:0016605 PML body(GO:0016605)
0.2 3.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)
0.8 3.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.3 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 2.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 2.9 GO:0055037 recycling endosome(GO:0055037)
0.7 2.7 GO:1990032 parallel fiber(GO:1990032)
0.1 2.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.8 2.4 GO:0043512 inhibin A complex(GO:0043512)
0.6 2.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 2.4 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 313 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 7.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 6.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 5.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 5.6 GO:0030552 cAMP binding(GO:0030552)
0.2 5.5 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 4.7 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 4.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 4.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 4.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 3.9 GO:0048495 Roundabout binding(GO:0048495)
0.8 3.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 3.8 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 3.8 GO:0030507 spectrin binding(GO:0030507)
0.2 3.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 3.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 3.1 GO:0017161 JUN kinase phosphatase activity(GO:0008579) phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 3.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 3.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 3.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)