Motif ID: Isl2

Z-value: 1.158


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_17402672 3.150 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr4_+_102589687 3.007 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chrX_+_164373363 2.984 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr10_-_63927434 2.876 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr11_+_103649498 2.702 ENSMUST00000057870.2
 Rprml
reprimo-like
chr13_+_67833235 2.112 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chr10_-_109764840 1.875 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr8_+_25911670 1.755 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr4_+_47386216 1.729 ENSMUST00000107725.2
 Tgfbr1
transforming growth factor, beta receptor I
chr8_-_9976294 1.714 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr9_-_90255927 1.662 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr14_-_100149764 1.648 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr13_+_48513570 1.589 ENSMUST00000065465.1
 A830005F24Rik
RIKEN cDNA A830005F24 gene
chr15_+_25773985 1.532 ENSMUST00000125667.1
 Myo10
myosin X
chr5_-_24902315 1.521 ENSMUST00000131486.1
 Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr9_+_53771499 1.472 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr6_+_134640940 1.468 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr1_-_172027269 1.421 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_-_125492710 1.401 ENSMUST00000108775.1
 Sipa1l2
signal-induced proliferation-associated 1 like 2
chr17_+_70561739 1.374 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0097352 autophagosome maturation(GO:0097352)
0.2 3.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.3 1.7 GO:0060017 parathyroid gland development(GO:0060017)
0.3 1.7 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 1.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.5 1.4 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.4 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 1.2 GO:0007530 sex determination(GO:0007530)
0.3 1.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 1.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.1 GO:0021591 ventricular system development(GO:0021591)
0.0 1.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.3 1.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 1.7 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 1.4 GO:0060187 cell pole(GO:0060187)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.0 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.2 0.9 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0001740 Barr body(GO:0001740)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0030552 cAMP binding(GO:0030552)
0.6 1.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.3 1.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.2 1.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.2 0.9 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.2 0.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)