Motif ID: Sox21

Z-value: 0.748


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.621.8e-02Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chrM_-_14060 2.669 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr4_+_139923349 1.701 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr10_-_116972609 1.611 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chrM_+_11734 1.307 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_-_25675047 1.160 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
 Tmem91


transmembrane protein 91


chrM_+_14138 1.098 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr2_-_73312701 1.054 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chr7_+_19368498 0.992 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr13_-_85127514 0.818 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr11_+_69045640 0.817 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr17_+_47737030 0.764 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr3_-_10208569 0.600 ENSMUST00000029041.4
 Fabp4
fatty acid binding protein 4, adipocyte
chr10_-_62507737 0.598 ENSMUST00000020271.6
 Srgn
serglycin
chr1_-_150465563 0.592 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
 Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chrM_+_10167 0.587 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr18_-_15403680 0.583 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chr1_+_171113918 0.564 ENSMUST00000129651.1
ENSMUST00000151340.1
 1700009P17Rik

RIKEN cDNA 1700009P17 gene

chr1_-_24612700 0.558 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr4_+_146654927 0.520 ENSMUST00000070932.3
 Gm13248
predicted gene 13248
chr11_+_114675431 0.517 ENSMUST00000045779.5
 Ttyh2
tweety homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 1.1 GO:0033762 response to glucagon(GO:0033762)
0.1 1.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.3 0.8 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.8 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.6 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.6 GO:0070295 renal water absorption(GO:0070295)
0.1 0.6 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0030539 male genitalia development(GO:0030539)
0.0 0.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.3 GO:0001842 neural fold formation(GO:0001842)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0070469 respiratory chain(GO:0070469)
0.1 1.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.3 GO:0090537 CERF complex(GO:0090537)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.2 0.5 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 0.3 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 0.3 GO:0034916 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.3 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)