Motif ID: Sox21

Z-value: 0.748


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.621.8e-02Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrM_-_14060 2.669 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr4_+_139923349 1.701 ENSMUST00000128563.1
Gm13028
predicted gene 13028
chr10_-_116972609 1.611 ENSMUST00000092165.4
Gm10271
predicted gene 10271
chrM_+_11734 1.307 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_-_25675047 1.160 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
Tmem91


transmembrane protein 91


chrM_+_14138 1.098 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr2_-_73312701 1.054 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr7_+_19368498 0.992 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr13_-_85127514 0.818 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr11_+_69045640 0.817 ENSMUST00000108666.1
ENSMUST00000021277.5
Aurkb

aurora kinase B

chr17_+_47737030 0.764 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr3_-_10208569 0.600 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr10_-_62507737 0.598 ENSMUST00000020271.6
Srgn
serglycin
chr1_-_150465563 0.592 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chrM_+_10167 0.587 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr18_-_15403680 0.583 ENSMUST00000079081.6
Aqp4
aquaporin 4
chr1_+_171113918 0.564 ENSMUST00000129651.1
ENSMUST00000151340.1
1700009P17Rik

RIKEN cDNA 1700009P17 gene

chr1_-_24612700 0.558 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr4_+_146654927 0.520 ENSMUST00000070932.3
Gm13248
predicted gene 13248
chr11_+_114675431 0.517 ENSMUST00000045779.5
Ttyh2
tweety homolog 2 (Drosophila)
chr17_-_90088343 0.497 ENSMUST00000173917.1
Nrxn1
neurexin I
chr2_+_136713444 0.411 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr9_-_79793378 0.394 ENSMUST00000034878.5
Tmem30a
transmembrane protein 30A
chr8_+_33517306 0.393 ENSMUST00000124496.1
Tex15
testis expressed gene 15
chr9_-_79793507 0.393 ENSMUST00000120690.1
Tmem30a
transmembrane protein 30A
chr15_+_6708372 0.386 ENSMUST00000061656.6
Rictor
RPTOR independent companion of MTOR, complex 2
chr7_+_123123870 0.375 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr17_+_6430112 0.334 ENSMUST00000179569.1
Dynlt1b
dynein light chain Tctex-type 1B
chr3_+_16183177 0.332 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3

YTH domain family 3

chr7_+_51621830 0.330 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr12_+_38783503 0.322 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr10_-_56228636 0.322 ENSMUST00000099739.3
Tbc1d32
TBC1 domain family, member 32
chr2_-_170194033 0.307 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr17_-_6655939 0.301 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr11_-_79504078 0.300 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr6_+_120666388 0.299 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr4_+_116708467 0.292 ENSMUST00000030452.6
Ccdc163
coiled-coil domain containing 163
chr4_+_138775735 0.291 ENSMUST00000030528.2
Pla2g2d
phospholipase A2, group IID
chr8_-_45410539 0.284 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr8_+_104961713 0.279 ENSMUST00000043183.7
Ces2g
carboxylesterase 2G
chr1_+_74362108 0.276 ENSMUST00000097697.1
Gm216
predicted gene 216
chr18_+_37504264 0.274 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr1_-_125913101 0.273 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr9_-_73968901 0.273 ENSMUST00000184666.1
Unc13c
unc-13 homolog C (C. elegans)
chr17_-_6317474 0.264 ENSMUST00000169415.1
Dynlt1a
dynein light chain Tctex-type 1A
chr1_-_135167606 0.259 ENSMUST00000027682.8
Gpr37l1
G protein-coupled receptor 37-like 1
chr4_-_25281752 0.251 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chr5_-_115484297 0.251 ENSMUST00000112067.1
Sirt4
sirtuin 4
chr4_+_116557658 0.249 ENSMUST00000030460.8
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr2_+_70508813 0.242 ENSMUST00000100041.2
Erich2
glutamate rich 2
chr17_+_6601671 0.241 ENSMUST00000092966.4
Dynlt1c
dynein light chain Tctex-type 1C
chr1_+_109993982 0.233 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr13_-_55100248 0.233 ENSMUST00000026997.5
ENSMUST00000127195.1
ENSMUST00000099496.3
Uimc1


ubiquitin interaction motif containing 1


chrX_+_13632769 0.231 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr4_-_25281801 0.226 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr13_-_19619820 0.220 ENSMUST00000002885.6
Epdr1
ependymin related protein 1 (zebrafish)
chr13_+_97137937 0.213 ENSMUST00000042084.6
ENSMUST00000160139.1
ENSMUST00000161639.1
ENSMUST00000161913.1
ENSMUST00000161825.1
ENSMUST00000161929.1
ENSMUST00000022170.7
Gfm2






G elongation factor, mitochondrial 2






chr11_-_109472611 0.211 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chrX_+_119927196 0.194 ENSMUST00000040961.2
ENSMUST00000113366.1
Pabpc5

poly(A) binding protein, cytoplasmic 5

chr14_+_64588112 0.189 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr19_+_44493472 0.183 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chr9_+_104063376 0.178 ENSMUST00000120854.1
Acad11
acyl-Coenzyme A dehydrogenase family, member 11
chr19_+_11518493 0.176 ENSMUST00000025580.3
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr11_-_53707269 0.168 ENSMUST00000124352.1
ENSMUST00000020649.7
Rad50

RAD50 homolog (S. cerevisiae)

chr2_-_35979624 0.152 ENSMUST00000028248.4
ENSMUST00000112976.2
Ttll11

tubulin tyrosine ligase-like family, member 11

chr2_-_79908428 0.135 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr13_-_32851176 0.128 ENSMUST00000091668.5
ENSMUST00000076352.6
Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chrX_-_75578188 0.123 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr3_+_32436376 0.120 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr9_+_104063678 0.116 ENSMUST00000047799.5
Acad11
acyl-Coenzyme A dehydrogenase family, member 11
chr10_-_13388753 0.113 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chrX_-_111536325 0.111 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr1_+_72284367 0.109 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr4_+_116558056 0.108 ENSMUST00000106475.1
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr9_-_104063049 0.108 ENSMUST00000035166.5
Uba5
ubiquitin-like modifier activating enzyme 5
chr11_+_69964758 0.101 ENSMUST00000108597.1
ENSMUST00000060651.5
ENSMUST00000108596.1
Cldn7


claudin 7


chr6_-_86733268 0.092 ENSMUST00000001185.7
Gmcl1
germ cell-less homolog 1 (Drosophila)
chr5_+_144255223 0.083 ENSMUST00000056578.6
Bri3
brain protein I3
chr9_-_22085391 0.082 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit



ECSIT homolog (Drosophila)



chr2_-_79908389 0.081 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr3_-_100685431 0.076 ENSMUST00000008907.7
Man1a2
mannosidase, alpha, class 1A, member 2
chrX_+_166170449 0.072 ENSMUST00000130880.2
ENSMUST00000056410.4
ENSMUST00000096252.3
ENSMUST00000087169.4
Gemin8



gem (nuclear organelle) associated protein 8



chr9_+_38718263 0.071 ENSMUST00000001544.5
ENSMUST00000118144.1
Vwa5a

von Willebrand factor A domain containing 5A

chr18_+_4993795 0.071 ENSMUST00000153016.1
Svil
supervillin
chr7_+_24112314 0.065 ENSMUST00000120006.1
ENSMUST00000005413.3
Zfp112

zinc finger protein 112

chr8_-_18741542 0.062 ENSMUST00000033846.6
Angpt2
angiopoietin 2
chr12_-_102423741 0.061 ENSMUST00000110020.1
Lgmn
legumain
chr7_+_141195047 0.056 ENSMUST00000047093.4
Lrrc56
leucine rich repeat containing 56
chr2_-_6935081 0.050 ENSMUST00000100426.2
Gm10855
predicted gene 10855
chr11_+_88047302 0.047 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr2_+_167015193 0.044 ENSMUST00000018143.9
ENSMUST00000176066.1
ENSMUST00000150571.1
Ddx27


DEAD (Asp-Glu-Ala-Asp) box polypeptide 27


chr8_-_111393810 0.039 ENSMUST00000038475.8
Fa2h
fatty acid 2-hydroxylase
chr2_+_174450678 0.036 ENSMUST00000016399.5
Tubb1
tubulin, beta 1 class VI
chr11_+_87699897 0.027 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr7_+_29953621 0.027 ENSMUST00000077142.2
C230062I16Rik
RIKEN cDNA C230062I16 gene
chr2_+_73312601 0.027 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr6_-_35539765 0.026 ENSMUST00000031866.5
Mtpn
myotrophin
chr16_+_32247221 0.022 ENSMUST00000178573.1
ENSMUST00000023474.3
Wdr53

WD repeat domain 53

chr14_+_61138445 0.019 ENSMUST00000089394.3
ENSMUST00000119509.1
Sacs

sacsin

chr9_+_109051090 0.017 ENSMUST00000059097.8
Shisa5
shisa homolog 5 (Xenopus laevis)
chr17_+_35916541 0.013 ENSMUST00000087211.2
Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr8_+_85432686 0.010 ENSMUST00000180883.1
1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr2_-_147186389 0.010 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr10_-_39122277 0.009 ENSMUST00000136546.1
Fam229b
family with sequence similarity 229, member B
chr1_-_172027269 0.008 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr7_+_6961160 0.003 ENSMUST00000054055.6
Usp29
ubiquitin specific peptidase 29

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 1.1 GO:0033762 response to glucagon(GO:0033762)
0.2 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.6 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.8 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.6 GO:0070295 renal water absorption(GO:0070295)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.6 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 0.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 0.2 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 1.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.2 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.3 GO:0001842 neural fold formation(GO:0001842)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.3 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0030539 male genitalia development(GO:0030539)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.3 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.2 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 0.1 GO:0032460 negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.3 GO:0090537 CERF complex(GO:0090537)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 4.6 GO:0070469 respiratory chain(GO:0070469)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 4.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.1 0.3 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 0.3 GO:0034916 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.3 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)