Motif ID: Nkx2-9

Z-value: 0.647


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_56613291-0.312.9e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_165004829 1.112 ENSMUST00000114890.2
 Gm17604
predicted gene, 17604
chr7_-_101921186 0.862 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr1_+_59256906 0.520 ENSMUST00000160662.1
ENSMUST00000114248.2
 Cdk15

cyclin-dependent kinase 15

chr6_-_101377897 0.483 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr12_-_24493656 0.474 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr2_+_140152043 0.464 ENSMUST00000104994.2
 Gm17374
predicted gene, 17374
chr7_-_101921175 0.454 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr18_+_77185815 0.417 ENSMUST00000079618.4
 St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr2_+_103969528 0.406 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr9_+_57504012 0.398 ENSMUST00000080514.7
 Rpp25
ribonuclease P/MRP 25 subunit
chr11_-_84068766 0.384 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr10_+_82378593 0.370 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chr3_-_89245159 0.360 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr3_-_37125943 0.327 ENSMUST00000029275.5
 Il2
interleukin 2
chr8_+_123212857 0.326 ENSMUST00000060133.6
 Spata33
spermatogenesis associated 33
chr11_+_70030023 0.320 ENSMUST00000143920.2
 Dlg4
discs, large homolog 4 (Drosophila)
chrX_+_56779437 0.301 ENSMUST00000114773.3
 Fhl1
four and a half LIM domains 1
chrX_-_95658379 0.297 ENSMUST00000119640.1
 Zc4h2
zinc finger, C4H2 domain containing
chr13_-_71963713 0.285 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr6_-_6217023 0.268 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.4 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.4 GO:2000821 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of grooming behavior(GO:2000821)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.2 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.2 GO:1903225 regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.2 GO:2000983 regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984)
0.1 0.2 GO:1903525 regulation of membrane tubulation(GO:1903525)
0.0 0.2 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.0 0.2 GO:0019249 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0 0.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.2 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.2 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0070878 primary miRNA binding(GO:0070878)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)