Motif ID: Runx2_Bcl11a

Z-value: 1.872

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078173_24078219-0.293.1e-01Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_83649349 6.786 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr4_-_136892867 5.759 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr19_+_3935186 5.305 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr3_-_87263518 5.033 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr13_-_37050237 4.017 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr1_-_140183404 4.005 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr5_+_90772435 3.854 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr3_-_87263703 3.415 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr4_+_144892813 3.305 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr10_+_61171954 3.122 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr3_-_90514250 3.098 ENSMUST00000107340.1
ENSMUST00000060738.8
 S100a1

S100 calcium binding protein A1

chr11_+_82045705 2.888 ENSMUST00000021011.2
 Ccl7
chemokine (C-C motif) ligand 7
chr12_+_118846329 2.733 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr2_-_25470031 2.707 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr1_-_172297989 2.683 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr11_-_106388066 2.508 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr11_+_105975204 2.505 ENSMUST00000001964.7
 Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr4_+_144893127 2.443 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_-_126676357 2.407 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr15_+_3270767 2.373 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.6 6.9 GO:0042572 retinol metabolic process(GO:0042572)
1.0 5.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 5.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.8 5.3 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.3 5.1 GO:0018149 peptide cross-linking(GO:0018149)
0.4 4.4 GO:0051923 sulfation(GO:0051923)
0.8 3.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.5 3.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.2 3.6 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4 3.0 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.3 2.9 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.9 2.7 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.5 2.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.8 2.5 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.3 2.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.4 GO:0071361 cellular response to ethanol(GO:0071361)
0.3 2.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 2.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 2.3 GO:0048515 spermatid differentiation(GO:0048515)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.8 GO:0005615 extracellular space(GO:0005615)
0.2 16.8 GO:0072562 blood microparticle(GO:0072562)
0.8 6.4 GO:0032009 early phagosome(GO:0032009)
0.4 4.6 GO:0031091 platelet alpha granule(GO:0031091)
0.4 3.5 GO:0042629 mast cell granule(GO:0042629)
0.1 2.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 2.6 GO:0097225 sperm midpiece(GO:0097225)
0.3 2.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 1.8 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.4 1.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.0 7.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.0 5.9 GO:0001851 complement component C3b binding(GO:0001851)
0.0 5.0 GO:0005509 calcium ion binding(GO:0005509)
0.5 4.8 GO:0035325 Toll-like receptor binding(GO:0035325)
1.5 4.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
1.0 4.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
1.3 3.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 3.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.9 3.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 3.1 GO:0044548 S100 protein binding(GO:0044548)
0.3 2.8 GO:1990239 steroid hormone binding(GO:1990239)
0.1 2.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 2.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 2.7 GO:0008517 folic acid transporter activity(GO:0008517)
0.6 2.5 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.4 2.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.1 2.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)