Motif ID: Tfap4

Z-value: 1.119


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_45597470.696.8e-03Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 8.435 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr5_+_90772435 5.204 ENSMUST00000031320.6
 Pf4
platelet factor 4
chrX_+_169685191 4.288 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr10_-_102490418 3.679 ENSMUST00000020040.3
 Nts
neurotensin
chr7_-_97417730 3.340 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr3_+_90537242 3.179 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr7_+_107567445 2.804 ENSMUST00000120990.1
 Olfml1
olfactomedin-like 1
chr3_+_118430299 2.583 ENSMUST00000180774.1
 Gm26871
predicted gene, 26871
chr3_+_5218546 2.578 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr8_+_66386292 2.518 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_+_111733924 2.375 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr5_-_28210022 2.357 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chrY_+_90843934 2.344 ENSMUST00000178550.1
 Gm21742
predicted gene, 21742
chr3_+_90537306 2.293 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr8_-_115707778 2.231 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr3_+_84925476 2.061 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr6_-_126939524 2.022 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr1_+_84839833 2.021 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr1_-_97977233 1.974 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr16_+_43510267 1.952 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0048663 neuron fate commitment(GO:0048663)
1.0 5.2 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.0 3.4 GO:0051592 response to calcium ion(GO:0051592)
0.1 3.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.8 3.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 3.1 GO:0008542 visual learning(GO:0008542)
0.1 3.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 2.7 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 2.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.7 2.2 GO:0015889 cobalamin transport(GO:0015889)
0.1 2.2 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 2.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 2.0 GO:0009404 toxin metabolic process(GO:0009404)
0.1 2.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 2.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 1.9 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 1.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 1.6 GO:0070306 lens fiber cell differentiation(GO:0070306)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0005667 transcription factor complex(GO:0005667)
0.5 5.2 GO:0031091 platelet alpha granule(GO:0031091)
0.7 2.7 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 2.6 GO:0043679 axon terminus(GO:0043679)
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 2.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 2.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.4 GO:0032009 early phagosome(GO:0032009)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0030315 T-tubule(GO:0030315)
0.1 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0042803 protein homodimerization activity(GO:0042803)
1.7 5.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 4.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 3.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.4 3.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 2.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.5 GO:0042287 MHC protein binding(GO:0042287)
0.3 2.2 GO:0031419 cobalamin binding(GO:0031419)
0.4 2.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 2.1 GO:0005179 hormone activity(GO:0005179)
0.7 2.0 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 2.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.3 1.9 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 1.6 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 1.5 GO:0016151 nickel cation binding(GO:0016151)
0.0 1.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.5 GO:0030276 clathrin binding(GO:0030276)