Motif ID: Smad4

Z-value: 0.884


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.185.5e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_153652943 3.133 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr11_-_33147400 2.983 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr11_-_95514570 2.971 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr10_-_127534540 2.360 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr5_+_75574916 1.251 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr6_-_138422898 1.202 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr19_+_5740885 1.016 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr1_+_152399824 0.987 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr9_-_45936049 0.972 ENSMUST00000034590.2
 Tagln
transgelin
chr7_+_45216671 0.927 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr11_-_60115226 0.917 ENSMUST00000130746.1
 4930412M03Rik
RIKEN cDNA 4930412M03 gene
chr17_+_72918298 0.876 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr7_+_45215753 0.842 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr18_+_57133065 0.836 ENSMUST00000075770.6
 Megf10
multiple EGF-like-domains 10
chr17_+_34597852 0.834 ENSMUST00000174496.2
ENSMUST00000015596.3
ENSMUST00000173992.1
 Ager


advanced glycosylation end product-specific receptor


chr3_+_127633134 0.792 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr6_+_54040078 0.730 ENSMUST00000127323.2
 Chn2
chimerin (chimaerin) 2
chrX_+_41401476 0.711 ENSMUST00000165288.1
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr5_-_24601961 0.701 ENSMUST00000030791.7
 Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr10_-_42583628 0.699 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.7 3.0 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 1.8 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 1.3 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 1.0 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 1.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 0.9 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.2 0.8 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.2 0.7 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 0.7 GO:0021764 amygdala development(GO:0021764)
0.1 0.7 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.7 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 0.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.7 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.5 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0001891 phagocytic cup(GO:0001891)
0.2 0.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.0 3.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.0 GO:0050436 microfibril binding(GO:0050436)
0.1 1.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.0 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.7 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)