Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.730

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx6mm10_v2_chr2_-_36104060_361040730.789.7e-04Click!
Lmx1amm10_v2_chr1_+_167689108_1676892390.126.8e-01Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 4.524 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_11037968 4.279 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr2_+_116067213 3.846 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr6_-_147264124 3.455 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr7_-_45103747 3.427 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr16_+_43503607 3.250 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chrX_+_169685191 3.163 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr6_+_124304646 2.625 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr18_+_57468478 2.624 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr6_+_125552948 2.605 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr2_-_116067391 2.410 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr2_+_125136692 2.069 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chrM_+_2743 2.063 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr6_-_136875794 1.829 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr12_+_38780284 1.696 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_+_25372315 1.616 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr17_-_49564262 1.538 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr11_+_101582236 1.502 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
 Tmem106a



transmembrane protein 106A



chr15_-_79285502 1.388 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr16_+_42907563 1.366 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 4.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.6 3.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 3.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 3.2 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.8 GO:0022900 electron transport chain(GO:0022900)
0.1 2.6 GO:0006953 acute-phase response(GO:0006953)
0.0 2.5 GO:0001889 liver development(GO:0001889)
0.1 2.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 2.2 GO:0015889 cobalamin transport(GO:0015889)
0.1 2.1 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 1.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.4 1.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 1.4 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 1.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 1.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0070469 respiratory chain(GO:0070469)
0.5 2.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.7 GO:0000124 SAGA complex(GO:0000124)
0.1 1.6 GO:0043205 fibril(GO:0043205)
0.1 1.4 GO:0071439 clathrin complex(GO:0071439)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.5 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 4.3 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.2 3.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.1 3.4 GO:0019770 IgG receptor activity(GO:0019770)
0.4 2.6 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 2.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.5 1.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.3 GO:0008483 transaminase activity(GO:0008483)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)