Motif ID: Egr4

Z-value: 0.688


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137288273 2.324 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr19_+_6306456 1.494 ENSMUST00000025681.7
 Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr7_+_35119285 1.288 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chrX_+_36195968 1.239 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr19_-_5085483 1.121 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
 Tmem151a


transmembrane protein 151A


chrX_+_36195950 0.945 ENSMUST00000115257.1
 Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195904 0.938 ENSMUST00000115258.2
 Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195938 0.938 ENSMUST00000048067.3
 Zcchc12
zinc finger, CCHC domain containing 12
chr7_+_102267795 0.880 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr9_+_21032038 0.846 ENSMUST00000019616.4
 Icam5
intercellular adhesion molecule 5, telencephalin
chr14_+_84443553 0.770 ENSMUST00000071370.5
 Pcdh17
protocadherin 17
chr8_+_11312805 0.703 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr14_+_56668242 0.695 ENSMUST00000116468.1
 Mphosph8
M-phase phosphoprotein 8
chr10_+_19591949 0.679 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr12_+_17690793 0.674 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr13_+_48261427 0.668 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr8_-_11312731 0.664 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr11_-_19018956 0.637 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr6_-_28261907 0.594 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
 Zfp800



zinc finger protein 800



chr6_-_85451248 0.524 ENSMUST00000113770.1
ENSMUST00000032080.2
 Pradc1

protease-associated domain containing 1

chr17_-_31658729 0.484 ENSMUST00000166526.1
ENSMUST00000014684.4
 U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr2_+_156008088 0.483 ENSMUST00000088650.4
 Ergic3
ERGIC and golgi 3
chr11_-_19018714 0.481 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr2_-_48949206 0.480 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
 Orc4


origin recognition complex, subunit 4


chr2_+_156008045 0.478 ENSMUST00000006035.6
 Ergic3
ERGIC and golgi 3
chrX_+_7762652 0.443 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
 Tfe3



transcription factor E3



chr2_+_164785823 0.429 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr13_-_111490028 0.425 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr2_+_164785994 0.423 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr13_-_111490111 0.404 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr15_+_58141397 0.402 ENSMUST00000067563.7
 Wdyhv1
WDYHV motif containing 1
chr14_-_54926784 0.392 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr9_+_118926453 0.389 ENSMUST00000073109.5
 Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_-_86993682 0.388 ENSMUST00000018571.4
 Ypel2
yippee-like 2 (Drosophila)
chr19_-_50678642 0.369 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr12_+_76370266 0.366 ENSMUST00000042779.3
 Zbtb1
zinc finger and BTB domain containing 1
chr17_-_23677432 0.364 ENSMUST00000167059.1
ENSMUST00000024698.8
 Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr11_+_70000578 0.362 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr9_+_108306205 0.357 ENSMUST00000007959.8
 Rhoa
ras homolog gene family, member A
chr18_+_35829798 0.355 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr11_+_114851814 0.354 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
 Gprc5c


G protein-coupled receptor, family C, group 5, member C


chr9_-_95511897 0.348 ENSMUST00000079659.5
ENSMUST00000078374.6
 U2surp

U2 snRNP-associated SURP domain containing

chr19_-_5273080 0.309 ENSMUST00000025786.7
 Pacs1
phosphofurin acidic cluster sorting protein 1
chr4_+_127169131 0.306 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr4_+_130055010 0.303 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr2_+_32535315 0.302 ENSMUST00000133512.1
ENSMUST00000048375.5
 Fam102a

family with sequence similarity 102, member A

chr14_+_79481164 0.293 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr16_+_93883895 0.292 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr4_+_128883549 0.261 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr17_+_26138661 0.256 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
 Axin1


axin 1


chr13_-_55513427 0.256 ENSMUST00000069929.6
ENSMUST00000069968.6
ENSMUST00000131306.1
ENSMUST00000046246.6
 Pdlim7



PDZ and LIM domain 7



chr8_-_92356103 0.255 ENSMUST00000034183.3
 4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr14_-_79481268 0.250 ENSMUST00000022601.5
 Wbp4
WW domain binding protein 4
chr19_-_8786245 0.244 ENSMUST00000177216.1
 Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr9_+_65630552 0.235 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chr16_+_64851991 0.232 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr7_-_19404082 0.226 ENSMUST00000108458.3
 Klc3
kinesin light chain 3
chr2_-_119477613 0.225 ENSMUST00000110808.1
ENSMUST00000049920.7
 Ino80

INO80 homolog (S. cerevisiae)

chrX_-_20291728 0.222 ENSMUST00000115393.2
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr19_-_8786272 0.205 ENSMUST00000176610.1
ENSMUST00000177056.1
 Taf6l

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

chr15_+_26309039 0.201 ENSMUST00000140840.1
ENSMUST00000152841.1
 March11

membrane-associated ring finger (C3HC4) 11

chr11_+_4186789 0.196 ENSMUST00000041042.6
ENSMUST00000180088.1
 Tbc1d10a

TBC1 domain family, member 10a

chr19_-_8786408 0.195 ENSMUST00000176496.1
 Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr17_-_70851189 0.187 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_127149389 0.186 ENSMUST00000180811.1
 9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr3_+_144570687 0.177 ENSMUST00000106211.1
 Sep15
selenoprotein
chr5_-_96161742 0.175 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
 Cnot6l



CCR4-NOT transcription complex, subunit 6-like



chr11_+_114851507 0.170 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr10_-_116473875 0.167 ENSMUST00000068233.4
 Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr9_+_59750876 0.165 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
 Myo9a


myosin IXa


chr2_-_148045891 0.148 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chrX_-_143393893 0.147 ENSMUST00000166406.2
 Chrdl1
chordin-like 1
chr4_-_43046196 0.139 ENSMUST00000036462.5
 Fam214b
family with sequence similarity 214, member B
chr19_-_50678485 0.131 ENSMUST00000111756.3
 Sorcs1
VPS10 domain receptor protein SORCS 1
chr11_+_103116228 0.127 ENSMUST00000053063.5
 Hexim1
hexamethylene bis-acetamide inducible 1
chr12_+_78226627 0.127 ENSMUST00000110388.2
ENSMUST00000052472.4
 Gphn

gephyrin

chr2_+_91922178 0.127 ENSMUST00000170432.1
 Chrm4
cholinergic receptor, muscarinic 4
chrX_-_153037549 0.125 ENSMUST00000051484.3
 Mageh1
melanoma antigen, family H, 1
chr2_-_9883993 0.116 ENSMUST00000114915.2
 9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr13_+_55445301 0.099 ENSMUST00000001115.8
ENSMUST00000099482.3
 Grk6

G protein-coupled receptor kinase 6

chr11_-_87987528 0.096 ENSMUST00000020775.2
 Dynll2
dynein light chain LC8-type 2
chr5_-_31295862 0.089 ENSMUST00000041266.7
ENSMUST00000172435.1
 Fndc4

fibronectin type III domain containing 4

chr16_+_36071624 0.077 ENSMUST00000164916.1
ENSMUST00000163352.1
 Ccdc58

coiled-coil domain containing 58

chr14_+_75845093 0.074 ENSMUST00000110894.2
 Tpt1
tumor protein, translationally-controlled 1
chr18_+_86394952 0.070 ENSMUST00000058829.2
 Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr9_-_44440868 0.060 ENSMUST00000098837.1
 Foxr1
forkhead box R1
chr1_+_135132693 0.057 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr19_+_6363896 0.052 ENSMUST00000113487.1
 Sf1
splicing factor 1
chr6_-_4747019 0.051 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
 Sgce


sarcoglycan, epsilon


chr2_-_66634952 0.041 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr10_+_128232065 0.031 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chrX_+_7842056 0.031 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
 Otud5


OTU domain containing 5


chr11_-_102407899 0.028 ENSMUST00000124755.1
 Slc25a39
solute carrier family 25, member 39
chr19_-_21652714 0.021 ENSMUST00000177577.1
 1110059E24Rik
RIKEN cDNA 1110059E24 gene
chr7_-_4778141 0.019 ENSMUST00000094892.5
 Il11
interleukin 11
chr16_-_36071515 0.015 ENSMUST00000004057.7
 Fam162a
family with sequence similarity 162, member A
chrX_-_20291776 0.004 ENSMUST00000072451.4
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 2.3 GO:0019695 choline metabolic process(GO:0019695)
0.2 0.9 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.2 0.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 1.3 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 0.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.4 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366)
0.1 1.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 0.4 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.8 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 0.4 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.3 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0051189 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.7 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.1 GO:0010359 regulation of anion channel activity(GO:0010359)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0033622 integrin activation(GO:0033622)
0.0 1.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.3 1.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 4.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0030914 STAGA complex(GO:0030914)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 4.1 GO:0032183 SUMO binding(GO:0032183)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 1.3 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0050733 RS domain binding(GO:0050733)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.4 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)