Motif ID: Egr4

Z-value: 0.688


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_137288273 2.324 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr19_+_6306456 1.494 ENSMUST00000025681.7
 Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr7_+_35119285 1.288 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chrX_+_36195968 1.239 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr19_-_5085483 1.121 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
 Tmem151a


transmembrane protein 151A


chrX_+_36195950 0.945 ENSMUST00000115257.1
 Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195904 0.938 ENSMUST00000115258.2
 Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195938 0.938 ENSMUST00000048067.3
 Zcchc12
zinc finger, CCHC domain containing 12
chr7_+_102267795 0.880 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr9_+_21032038 0.846 ENSMUST00000019616.4
 Icam5
intercellular adhesion molecule 5, telencephalin
chr14_+_84443553 0.770 ENSMUST00000071370.5
 Pcdh17
protocadherin 17
chr8_+_11312805 0.703 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr14_+_56668242 0.695 ENSMUST00000116468.1
 Mphosph8
M-phase phosphoprotein 8
chr10_+_19591949 0.679 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr12_+_17690793 0.674 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr13_+_48261427 0.668 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr8_-_11312731 0.664 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr11_-_19018956 0.637 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr6_-_28261907 0.594 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
 Zfp800



zinc finger protein 800



chr6_-_85451248 0.524 ENSMUST00000113770.1
ENSMUST00000032080.2
 Pradc1

protease-associated domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 2.3 GO:0019695 choline metabolic process(GO:0019695)
0.0 1.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 1.3 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.2 0.9 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.8 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.2 0.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.0 0.7 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.4 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366)
0.1 0.4 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.4 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.3 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0033622 integrin activation(GO:0033622)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0016607 nuclear speck(GO:0016607)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.3 1.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.4 1.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0030914 STAGA complex(GO:0030914)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 GO:0032183 SUMO binding(GO:0032183)
0.6 2.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 1.3 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.1 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.4 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)