Motif ID: Tbx4

Z-value: 0.499


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_125490688 3.315 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr3_+_75557530 1.689 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr1_+_153665666 1.439 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 1.436 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_6730051 1.294 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_+_153665587 1.021 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr2_-_57114970 0.975 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_-_89742490 0.942 ENSMUST00000109546.2
 Vcan
versican
chr1_+_153665627 0.900 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr6_+_15196949 0.777 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr2_-_13011747 0.721 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr11_-_84068357 0.685 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr11_-_84068766 0.616 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr12_-_31634592 0.496 ENSMUST00000020979.7
ENSMUST00000177962.1
 Bcap29

B cell receptor associated protein 29

chrX_-_162829379 0.466 ENSMUST00000041370.4
ENSMUST00000112316.2
ENSMUST00000112315.1
 Txlng


taxilin gamma


chr1_+_6730135 0.465 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr7_-_103813913 0.460 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr14_-_70642268 0.430 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr9_+_86743641 0.429 ENSMUST00000179574.1
 Prss35
protease, serine, 35
chr9_+_35421541 0.414 ENSMUST00000119129.2
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr9_+_86743616 0.405 ENSMUST00000036426.6
 Prss35
protease, serine, 35
chr2_+_52857844 0.400 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr7_-_28302238 0.373 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_-_134332928 0.344 ENSMUST00000168515.1
 Ppfia4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr9_-_102354685 0.338 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr11_-_116654245 0.336 ENSMUST00000021166.5
 Cygb
cytoglobin
chr8_-_31918203 0.336 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr6_+_42286709 0.328 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr1_-_138847579 0.320 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr5_+_32136458 0.302 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr11_+_78178105 0.283 ENSMUST00000147819.1
 Tlcd1
TLC domain containing 1
chr11_-_115813621 0.277 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr13_+_93304066 0.274 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr15_-_11905609 0.270 ENSMUST00000066529.3
 Npr3
natriuretic peptide receptor 3
chrM_+_10167 0.239 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_9870 0.237 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr4_+_53440516 0.227 ENSMUST00000107651.2
ENSMUST00000107647.1
 Slc44a1

solute carrier family 44, member 1

chr11_-_22286795 0.225 ENSMUST00000109563.2
ENSMUST00000180360.1
 Ehbp1

EH domain binding protein 1

chr4_+_53440388 0.208 ENSMUST00000102911.3
ENSMUST00000107646.2
 Slc44a1

solute carrier family 44, member 1

chr16_-_50330987 0.205 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr16_+_62814676 0.199 ENSMUST00000055557.5
 Stx19
syntaxin 19
chr10_-_127341583 0.198 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr9_+_108296853 0.183 ENSMUST00000035230.5
 Amt
aminomethyltransferase
chr12_-_56345862 0.170 ENSMUST00000021416.7
 Mbip
MAP3K12 binding inhibitory protein 1
chr13_+_80886095 0.170 ENSMUST00000161441.1
 Arrdc3
arrestin domain containing 3
chr6_+_42286676 0.165 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr1_-_24612700 0.162 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr4_+_43641262 0.160 ENSMUST00000123351.1
ENSMUST00000128549.1
 Npr2

natriuretic peptide receptor 2

chr7_-_141443989 0.158 ENSMUST00000026580.5
 Lrdd
leucine-rich and death domain containing
chr9_-_95845215 0.146 ENSMUST00000093800.2
 Pls1
plastin 1 (I-isoform)
chr6_-_28261907 0.146 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
 Zfp800



zinc finger protein 800



chr7_+_46796088 0.142 ENSMUST00000006774.4
ENSMUST00000165031.1
 Gtf2h1

general transcription factor II H, polypeptide 1

chr15_-_10470490 0.141 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr3_+_51415986 0.141 ENSMUST00000029303.7
 Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr7_+_89980749 0.139 ENSMUST00000181784.1
 Gm26529
predicted gene, 26529
chr3_-_103791537 0.134 ENSMUST00000118317.1
 Hipk1
homeodomain interacting protein kinase 1
chr11_-_20741447 0.131 ENSMUST00000177543.1
 Aftph
aftiphilin
chr8_+_79028317 0.122 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr14_+_45351473 0.121 ENSMUST00000111835.2
 Styx
serine/threonine/tyrosine interaction protein
chr4_+_148000722 0.120 ENSMUST00000103230.4
 Nppa
natriuretic peptide type A
chr7_-_46795881 0.118 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
 Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr9_-_69760924 0.111 ENSMUST00000071281.4
 Foxb1
forkhead box B1
chr9_+_44326804 0.111 ENSMUST00000054708.3
 Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr10_+_86705811 0.108 ENSMUST00000061458.7
ENSMUST00000075632.6
 BC030307

cDNA sequence BC030307

chr17_-_78937031 0.100 ENSMUST00000024885.8
 Cebpz
CCAAT/enhancer binding protein zeta
chr5_+_31094984 0.097 ENSMUST00000066505.1
 Gm9924
predicted gene 9924
chr10_-_85916902 0.091 ENSMUST00000037646.7
 Prdm4
PR domain containing 4
chr8_+_79028587 0.087 ENSMUST00000119254.1
 Zfp827
zinc finger protein 827
chr1_+_132316112 0.085 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr9_-_48495321 0.085 ENSMUST00000170000.2
 Rbm7
RNA binding motif protein 7
chr3_-_103791075 0.085 ENSMUST00000106845.2
ENSMUST00000029438.8
ENSMUST00000121324.1
 Hipk1


homeodomain interacting protein kinase 1


chr10_-_128211788 0.082 ENSMUST00000061995.8
 Spryd4
SPRY domain containing 4
chrX_+_20425688 0.080 ENSMUST00000115384.2
 Phf16
PHD finger protein 16
chr11_-_69900930 0.077 ENSMUST00000018714.6
ENSMUST00000128046.1
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr12_+_102948843 0.077 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr11_-_69900949 0.075 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr11_+_95414078 0.074 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
 Spop



speckle-type POZ protein



chr13_-_108158584 0.073 ENSMUST00000163558.1
 Ndufaf2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
chr19_-_10604258 0.069 ENSMUST00000037678.6
 Dak
dihydroxyacetone kinase 2 homolog (yeast)
chr13_+_96542727 0.066 ENSMUST00000077672.4
ENSMUST00000109444.2
 Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr12_+_102949450 0.066 ENSMUST00000179002.1
 Unc79
unc-79 homolog (C. elegans)
chr17_+_35135695 0.065 ENSMUST00000174478.1
ENSMUST00000174281.2
ENSMUST00000173550.1
 Bag6


BCL2-associated athanogene 6


chr11_-_98149551 0.065 ENSMUST00000103143.3
 Fbxl20
F-box and leucine-rich repeat protein 20
chr10_+_96136603 0.062 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr19_-_28963863 0.057 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr4_+_84884418 0.051 ENSMUST00000169371.2
 Cntln
centlein, centrosomal protein
chr6_+_29398920 0.046 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr6_+_39573894 0.045 ENSMUST00000051249.6
 Adck2
aarF domain containing kinase 2
chr6_+_39573858 0.036 ENSMUST00000140364.1
 Adck2
aarF domain containing kinase 2
chr11_-_78751656 0.034 ENSMUST00000059468.4
 Fam58b
family with sequence similarity 58, member B
chr11_+_23306910 0.033 ENSMUST00000137823.1
 Usp34
ubiquitin specific peptidase 34
chr6_+_83054653 0.031 ENSMUST00000092618.6
 Aup1
ancient ubiquitous protein 1
chr4_-_36056726 0.031 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr1_+_74542881 0.025 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
 Plcd4




phospholipase C, delta 4




chr19_-_37207293 0.024 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr11_-_106301801 0.023 ENSMUST00000103071.3
 Gh
growth hormone
chr7_-_115824699 0.023 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr15_+_98634743 0.016 ENSMUST00000003442.7
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr13_-_111490028 0.007 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr17_+_78937124 0.004 ENSMUST00000024887.4
 Ndufaf7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7
chr4_+_11191354 0.004 ENSMUST00000170901.1
 Ccne2
cyclin E2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.3 3.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.0 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:0015871 choline transport(GO:0015871)
0.1 0.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.3 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.3 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.6 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.2 GO:0090325 regulation of locomotion involved in locomotory behavior(GO:0090325) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.3 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.3 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0060032 notochord regression(GO:0060032)
0.0 0.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 1.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0019348 dolichol-linked oligosaccharide biosynthetic process(GO:0006488) dolichol metabolic process(GO:0019348)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 3.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.5 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)