Motif ID: Fosb

Z-value: 0.825


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.506.8e-02Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_64090241 4.236 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 3.079 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr16_+_78930940 2.813 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr8_+_36489191 2.123 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr8_-_8639363 1.761 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr10_+_26078255 1.719 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr13_-_113663670 1.714 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr17_+_35841668 1.645 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr3_+_123267445 1.532 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr9_+_114978507 1.445 ENSMUST00000183104.1
 Osbpl10
oxysterol binding protein-like 10
chr6_-_113934679 1.348 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr9_+_104566677 1.016 ENSMUST00000157006.1
 Cpne4
copine IV
chr2_-_151632471 1.012 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr2_+_118663235 0.970 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr5_-_5265224 0.910 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr10_+_116143881 0.873 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr7_-_29505447 0.867 ENSMUST00000183096.1
ENSMUST00000085809.4
 Sipa1l3

signal-induced proliferation-associated 1 like 3

chr8_+_107293500 0.813 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr1_+_134560190 0.789 ENSMUST00000112198.1
ENSMUST00000112197.1
 Kdm5b

lysine (K)-specific demethylase 5B

chr17_-_35697971 0.772 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr3_+_55461758 0.753 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr14_+_27622433 0.752 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr10_+_88091070 0.744 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr2_-_45110241 0.657 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr1_+_134560157 0.601 ENSMUST00000047714.7
 Kdm5b
lysine (K)-specific demethylase 5B
chr14_+_79426454 0.599 ENSMUST00000061222.7
 Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr11_+_117232254 0.530 ENSMUST00000106354.2
 Sept9
septin 9
chr7_-_133782721 0.519 ENSMUST00000063669.1
 Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr11_-_3914664 0.510 ENSMUST00000109995.1
ENSMUST00000051207.1
 Slc35e4

solute carrier family 35, member E4

chr17_+_35841491 0.495 ENSMUST00000082337.6
 Mdc1
mediator of DNA damage checkpoint 1
chr11_-_120630516 0.494 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr1_+_86064619 0.489 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr19_+_5447692 0.479 ENSMUST00000025850.5
 Fosl1
fos-like antigen 1
chr15_-_102257449 0.457 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr18_+_82910863 0.453 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr12_+_16810940 0.437 ENSMUST00000020908.7
 E2f6
E2F transcription factor 6
chr15_+_102503722 0.433 ENSMUST00000096145.4
 Gm10337
predicted gene 10337
chr15_-_102257306 0.422 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr6_-_129533267 0.414 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr11_-_84067063 0.412 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr2_+_152105722 0.395 ENSMUST00000099225.2
 Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr1_-_182517447 0.395 ENSMUST00000068505.8
 Capn2
calpain 2
chr6_+_86849488 0.375 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr9_+_122888471 0.367 ENSMUST00000063980.6
 Zkscan7
zinc finger with KRAB and SCAN domains 7
chr2_-_25224653 0.363 ENSMUST00000043584.4
 Tubb4b
tubulin, beta 4B class IVB
chr2_+_156475844 0.353 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr11_+_80428598 0.345 ENSMUST00000173938.1
ENSMUST00000017572.7
 Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr12_-_84194007 0.317 ENSMUST00000110294.1
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr16_+_17561885 0.314 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr2_-_18048784 0.308 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr2_+_156475803 0.299 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr11_+_77801325 0.295 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
 Myo18a




myosin XVIIIA




chrX_+_73675500 0.291 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr1_-_12991109 0.264 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr9_-_119977250 0.254 ENSMUST00000035101.7
 Csrnp1
cysteine-serine-rich nuclear protein 1
chr14_+_66635251 0.200 ENSMUST00000159365.1
ENSMUST00000054661.1
ENSMUST00000159068.1
 Adra1a


adrenergic receptor, alpha 1a


chr5_-_86676346 0.173 ENSMUST00000038448.6
 Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr9_+_96259246 0.169 ENSMUST00000179065.1
ENSMUST00000165768.2
 Tfdp2

transcription factor Dp 2

chr2_-_29253001 0.169 ENSMUST00000071201.4
 Ntng2
netrin G2
chr6_+_17463927 0.168 ENSMUST00000115442.1
 Met
met proto-oncogene
chr11_+_77801291 0.164 ENSMUST00000100794.3
 Myo18a
myosin XVIIIA
chr6_+_42350000 0.160 ENSMUST00000164375.1
 Zyx
zyxin
chr11_-_102365111 0.142 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_+_143915273 0.132 ENSMUST00000103172.3
 Dstn
destrin
chr15_-_76014318 0.128 ENSMUST00000060807.5
 Fam83h
family with sequence similarity 83, member H
chr11_-_43747963 0.125 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chr12_-_85288419 0.116 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr4_-_140665891 0.106 ENSMUST00000069623.5
 Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_55758458 0.103 ENSMUST00000001497.7
 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr4_-_43558386 0.083 ENSMUST00000130353.1
 Tln1
talin 1
chrX_+_96455359 0.068 ENSMUST00000033553.7
 Heph
hephaestin
chr1_-_171240055 0.064 ENSMUST00000131286.1
 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr7_-_4778141 0.038 ENSMUST00000094892.5
 Il11
interleukin 11
chr2_+_52038005 0.014 ENSMUST00000065927.5
 Tnfaip6
tumor necrosis factor alpha induced protein 6
chr6_+_42349826 0.010 ENSMUST00000070635.6
 Zyx
zyxin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 0.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 1.3 GO:0048840 otolith development(GO:0048840)
0.2 1.8 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 0.9 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 1.4 GO:0034720 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) histone H3-K4 demethylation(GO:0034720) mammary duct terminal end bud growth(GO:0060763)
0.1 0.7 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.5 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.1 0.5 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.2 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.1 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 1.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.5 GO:0009409 response to cold(GO:0009409)
0.0 2.1 GO:0008033 tRNA processing(GO:0008033)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0033198 response to ATP(GO:0033198)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0045298 tubulin complex(GO:0045298)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 7.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.2 2.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 7.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.2 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.1 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.1 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.9 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0043531 ADP binding(GO:0043531)