Motif ID: Foxb1

Z-value: 1.376


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_697609400.421.3e-01Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_14901344 4.403 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr1_-_158814469 3.921 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr6_+_14901440 3.418 ENSMUST00000128567.1
 Foxp2
forkhead box P2
chr4_+_102430047 3.233 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr18_-_47333311 3.147 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr15_-_48791933 2.959 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr6_+_8520008 2.953 ENSMUST00000162567.1
ENSMUST00000161217.1
 Glcci1

glucocorticoid induced transcript 1

chr2_+_55437100 2.945 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr6_-_56362356 2.741 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr1_-_72536930 2.662 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr2_-_45110336 2.375 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chrX_+_41401128 2.320 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr10_+_37139558 2.217 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr15_-_11905609 2.216 ENSMUST00000066529.3
 Npr3
natriuretic peptide receptor 3
chrX_-_43274786 2.060 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr1_-_156034826 1.977 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr5_-_51567717 1.936 ENSMUST00000127135.1
ENSMUST00000151104.1
 Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr1_+_179546303 1.853 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein
chr11_-_107348130 1.767 ENSMUST00000134763.1
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr10_+_69925484 1.764 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr4_-_135494615 1.763 ENSMUST00000102549.3
 Nipal3
NIPA-like domain containing 3
chr9_+_47530173 1.657 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr3_-_127499095 1.632 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr2_-_65529275 1.621 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr6_+_135065651 1.620 ENSMUST00000050104.7
 Gprc5a
G protein-coupled receptor, family C, group 5, member A
chr10_+_69925800 1.612 ENSMUST00000182029.1
 Ank3
ankyrin 3, epithelial
chr10_+_69925766 1.534 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr13_+_5861489 1.518 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr3_-_123672321 1.415 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr10_+_69925954 1.391 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr1_+_25830657 1.383 ENSMUST00000064487.1
 Gm9884
predicted gene 9884
chr3_+_96245530 1.350 ENSMUST00000074976.6
 Hist2h2aa1
histone cluster 2, H2aa1
chr10_-_96409038 1.320 ENSMUST00000179683.1
 Gm20091
predicted gene, 20091
chr9_+_53850243 1.138 ENSMUST00000048485.5
 Sln
sarcolipin
chr5_-_137502402 1.126 ENSMUST00000111035.1
ENSMUST00000031728.4
 Pop7

processing of precursor 7, ribonuclease P family, (S. cerevisiae)

chr1_+_43445736 1.044 ENSMUST00000086421.5
ENSMUST00000114744.1
 Nck2

non-catalytic region of tyrosine kinase adaptor protein 2

chr7_+_67655414 0.949 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr3_-_96240317 0.909 ENSMUST00000078756.5
 Hist2h2aa2
histone cluster 2, H2aa2
chr8_+_58912257 0.902 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr2_+_30061754 0.888 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr16_-_34095983 0.870 ENSMUST00000114973.1
ENSMUST00000114964.1
 Kalrn

kalirin, RhoGEF kinase

chr14_-_93888732 0.831 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr4_-_135494499 0.831 ENSMUST00000105856.2
 Nipal3
NIPA-like domain containing 3
chr1_-_170867761 0.821 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr18_+_36952621 0.817 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr16_-_74411292 0.768 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr17_+_70522149 0.758 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr8_+_94037198 0.750 ENSMUST00000109556.2
ENSMUST00000093301.2
ENSMUST00000060632.7
 Ogfod1


2-oxoglutarate and iron-dependent oxygenase domain containing 1


chr7_+_24271568 0.746 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr2_-_163645125 0.717 ENSMUST00000017851.3
 Serinc3
serine incorporator 3
chrX_+_150594420 0.715 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_119900099 0.707 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr12_-_84450944 0.687 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr19_+_47228804 0.666 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr3_+_55782500 0.652 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr17_-_70851710 0.651 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr12_-_31950535 0.642 ENSMUST00000172314.2
 Hbp1
high mobility group box transcription factor 1
chrX_-_94123087 0.629 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr1_+_179961110 0.598 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr14_+_48120841 0.546 ENSMUST00000073150.4
 Peli2
pellino 2
chr1_+_9848375 0.523 ENSMUST00000097826.4
 Sgk3
serum/glucocorticoid regulated kinase 3
chrX_+_106920618 0.447 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr12_-_31950210 0.391 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
 Hbp1


high mobility group box transcription factor 1


chr6_+_92940572 0.388 ENSMUST00000181145.1
ENSMUST00000181840.1
 9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr17_+_70522083 0.383 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr3_+_76075583 0.380 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr14_-_55643251 0.350 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
 Tm9sf1




transmembrane 9 superfamily member 1




chr1_-_181211437 0.333 ENSMUST00000162963.1
ENSMUST00000162819.1
 Wdr26

WD repeat domain 26

chr1_+_9848270 0.329 ENSMUST00000171265.1
 Sgk3
serum/glucocorticoid regulated kinase 3
chr7_+_29071597 0.322 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr19_+_5041337 0.318 ENSMUST00000116567.2
 Brms1
breast cancer metastasis-suppressor 1
chr3_-_123690806 0.305 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr18_-_43687695 0.295 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr12_-_101958148 0.285 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chr6_-_3494587 0.273 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr13_+_40859768 0.269 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr12_-_31950170 0.264 ENSMUST00000176520.1
 Hbp1
high mobility group box transcription factor 1
chr5_+_143817786 0.261 ENSMUST00000100487.4
 Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
chr7_-_34655500 0.242 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr11_-_98329641 0.239 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr2_+_130277157 0.222 ENSMUST00000028890.8
ENSMUST00000159373.1
 Nop56

NOP56 ribonucleoprotein

chr1_+_81077204 0.222 ENSMUST00000123720.1
 Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr10_+_26229707 0.165 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr16_+_44394771 0.152 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr9_-_101198999 0.125 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr3_-_95904683 0.104 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr8_+_93810832 0.101 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr6_+_5390387 0.088 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr2_+_181767040 0.081 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr2_+_181767283 0.047 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_-_176917518 0.041 ENSMUST00000108931.2
 Gm14296
predicted gene 14296
chr1_-_179546261 0.036 ENSMUST00000027769.5
 Tfb2m
transcription factor B2, mitochondrial
chr1_+_10056922 0.033 ENSMUST00000149214.1
 Cspp1
centrosome and spindle pole associated protein 1
chr4_-_139833524 0.010 ENSMUST00000030508.7
 Pax7
paired box gene 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.6 1.9 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.6 6.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 1.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.5 6.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 2.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.4 2.4 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 1.6 GO:0046684 response to pyrethroid(GO:0046684)
0.3 1.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 1.0 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.3 0.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 3.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.2 2.0 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 1.6 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.2 0.7 GO:0009597 detection of virus(GO:0009597)
0.2 2.6 GO:0015693 magnesium ion transport(GO:0015693)
0.2 2.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 3.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 2.9 GO:0010107 potassium ion import(GO:0010107)
0.1 0.9 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.1 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.7 GO:0006449 regulation of translational termination(GO:0006449)
0.1 2.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.9 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 2.3 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.3 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.1 1.1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.6 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 3.9 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 1.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.5 GO:0007097 nuclear migration(GO:0007097)
0.0 2.3 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 2.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 3.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.7 GO:0070852 cell body fiber(GO:0070852)
0.1 1.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.6 GO:0031430 M band(GO:0031430)
0.1 2.6 GO:0097440 apical dendrite(GO:0097440)
0.1 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 2.7 GO:0005795 Golgi stack(GO:0005795)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 2.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 2.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 1.9 GO:0071253 connexin binding(GO:0071253)
0.3 2.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 7.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 1.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 1.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 2.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.0 GO:0005521 lamin binding(GO:0005521)
0.1 1.6 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 3.2 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.7 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 3.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.7 GO:0016790 thiolester hydrolase activity(GO:0016790)