Motif ID: Gsc2_Dmbx1

Z-value: 0.706

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_115939928-0.136.6e-01Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93595877 3.702 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr3_-_103737995 2.456 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr7_-_133015248 1.174 ENSMUST00000169570.1
 Ctbp2
C-terminal binding protein 2
chr8_-_113848615 1.092 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr11_-_70459957 0.966 ENSMUST00000019064.2
 Cxcl16
chemokine (C-X-C motif) ligand 16
chr4_+_102589687 0.892 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr11_-_107337556 0.807 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr5_+_77265454 0.765 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr10_-_6980376 0.736 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr15_+_4375462 0.709 ENSMUST00000061925.4
 Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr6_-_124840192 0.700 ENSMUST00000024206.5
 Gnb3
guanine nucleotide binding protein (G protein), beta 3
chrX_+_74424632 0.674 ENSMUST00000114129.2
ENSMUST00000132749.1
 Ikbkg

inhibitor of kappaB kinase gamma

chr14_-_118052235 0.643 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_+_12692430 0.543 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr1_-_168431695 0.501 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr16_-_46010212 0.480 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr17_+_27655572 0.451 ENSMUST00000045896.3
 Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr17_+_35861343 0.450 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr7_-_80403315 0.438 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr4_-_141053660 0.429 ENSMUST00000040222.7
 Crocc
ciliary rootlet coiled-coil, rootletin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 1.5 GO:0097320 membrane tubulation(GO:0097320)
0.1 1.1 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 1.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 1.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 0.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.8 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.6 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 0.5 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
0.0 0.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.0 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.0 1.0 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 0.8 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)