Motif ID: Thra
Z-value: 0.970
Transcription factors associated with Thra:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Thra | ENSMUSG00000058756.7 | Thra |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Thra | mm10_v2_chr11_+_98741871_98741894 | 0.30 | 3.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 5.1 | GO:1990034 | calcium ion export from cell(GO:1990034) |
0.4 | 2.5 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.3 | 2.4 | GO:0035902 | response to immobilization stress(GO:0035902) |
0.3 | 1.6 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.3 | 0.9 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
0.3 | 1.2 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
0.3 | 0.8 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
0.3 | 1.0 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.2 | 0.7 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
0.2 | 2.1 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.2 | 0.6 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
0.2 | 1.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.2 | 0.9 | GO:0071476 | cellular hypotonic response(GO:0071476) |
0.2 | 1.0 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
0.2 | 1.1 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.1 | 0.7 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
0.1 | 0.9 | GO:1903753 | cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) hard palate development(GO:0060022) negative regulation of p38MAPK cascade(GO:1903753) |
0.1 | 0.9 | GO:0007296 | vitellogenesis(GO:0007296) |
0.1 | 0.5 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
0.1 | 0.4 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
0.1 | 0.4 | GO:0072554 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
0.1 | 0.8 | GO:0051004 | plasma membrane to endosome transport(GO:0048227) regulation of lipoprotein lipase activity(GO:0051004) |
0.1 | 0.2 | GO:0055118 | negative regulation of cardiac muscle contraction(GO:0055118) |
0.1 | 0.8 | GO:0008343 | adult feeding behavior(GO:0008343) |
0.1 | 0.5 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
0.1 | 0.4 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
0.1 | 0.4 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
0.1 | 1.6 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
0.1 | 0.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.1 | 1.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 1.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.1 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.1 | 0.4 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
0.1 | 0.5 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
0.1 | 0.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) type I interferon biosynthetic process(GO:0045351) positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718) |
0.1 | 0.2 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
0.1 | 0.7 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
0.1 | 0.3 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
0.1 | 0.3 | GO:1901524 | regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525) |
0.1 | 1.9 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
0.1 | 0.4 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
0.0 | 0.3 | GO:0070314 | G1 to G0 transition(GO:0070314) |
0.0 | 1.2 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
0.0 | 0.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
0.0 | 0.4 | GO:0042473 | production of siRNA involved in RNA interference(GO:0030422) outer ear morphogenesis(GO:0042473) |
0.0 | 0.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
0.0 | 0.8 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.3 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
0.0 | 1.3 | GO:0007616 | long-term memory(GO:0007616) |
0.0 | 0.7 | GO:0015813 | L-glutamate transport(GO:0015813) |
0.0 | 0.1 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
0.0 | 0.4 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
0.0 | 0.3 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.0 | 1.2 | GO:0033344 | cholesterol efflux(GO:0033344) |
0.0 | 1.0 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
0.0 | 0.2 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
0.0 | 0.2 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
0.0 | 0.4 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
0.0 | 0.3 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
0.0 | 0.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 0.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
0.0 | 0.2 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.0 | 0.4 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.5 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
0.0 | 0.0 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
0.0 | 0.1 | GO:1905098 | negative regulation of translation in response to stress(GO:0032055) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
0.0 | 0.1 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
0.0 | 0.4 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
0.0 | 0.3 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) |
0.0 | 0.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.0 | 2.3 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.4 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.0 | 1.1 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
0.0 | 1.1 | GO:0006611 | protein export from nucleus(GO:0006611) |
0.0 | 3.0 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
0.0 | 0.2 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
0.0 | 0.6 | GO:0051693 | actin filament capping(GO:0051693) |
0.0 | 0.5 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.1 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.6 | GO:0032437 | cuticular plate(GO:0032437) |
0.2 | 2.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.2 | 0.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
0.2 | 2.5 | GO:0043194 | axon initial segment(GO:0043194) |
0.1 | 0.5 | GO:1990130 | Iml1 complex(GO:1990130) |
0.1 | 0.4 | GO:0032426 | stereocilium tip(GO:0032426) |
0.1 | 1.1 | GO:0032982 | myosin filament(GO:0032982) |
0.1 | 1.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.1 | 2.7 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 0.3 | GO:0002142 | stereocilia ankle link complex(GO:0002142) |
0.1 | 6.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.1 | 2.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.1 | 0.4 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
0.1 | 0.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
0.1 | 0.4 | GO:0097427 | microtubule bundle(GO:0097427) |
0.1 | 1.8 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 3.9 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.1 | GO:0071797 | LUBAC complex(GO:0071797) |
0.0 | 0.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 0.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.2 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
0.0 | 0.4 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 0.8 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.1 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.0 | 0.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 3.3 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.2 | GO:0045095 | keratin filament(GO:0045095) |
0.0 | 0.1 | GO:0071986 | Ragulator complex(GO:0071986) |
0.0 | 0.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.0 | 0.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.2 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.0 | 0.2 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
0.0 | 0.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 5.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.5 | 2.5 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
0.3 | 1.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.3 | 0.9 | GO:0004637 | phosphoribosylamine-glycine ligase activity(GO:0004637) |
0.3 | 1.2 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
0.3 | 1.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.2 | 1.4 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.2 | 1.6 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.2 | 1.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.2 | 0.9 | GO:0097016 | L27 domain binding(GO:0097016) |
0.2 | 0.8 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.2 | 0.9 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.2 | 1.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.1 | 0.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.1 | 0.9 | GO:0032795 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
0.1 | 0.5 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
0.1 | 1.2 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.1 | 0.8 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.1 | 0.8 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.1 | 2.4 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
0.1 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.1 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
0.1 | 2.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 0.7 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.0 | 0.5 | GO:0030274 | LIM domain binding(GO:0030274) |
0.0 | 1.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.4 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
0.0 | 0.2 | GO:0098518 | polynucleotide phosphatase activity(GO:0098518) |
0.0 | 0.5 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.4 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 0.2 | GO:0050692 | DBD domain binding(GO:0050692) |
0.0 | 0.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 0.2 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.0 | 0.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.2 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
0.0 | 0.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
0.0 | 0.1 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.1 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.9 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
0.0 | 0.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.0 | 0.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 2.0 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 1.1 | GO:0051087 | chaperone binding(GO:0051087) |
0.0 | 1.6 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
0.0 | 0.1 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.0 | 0.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
0.0 | 0.1 | GO:0019992 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) diacylglycerol binding(GO:0019992) |