Motif ID: Tbx2

Z-value: 1.185


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.078.2e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 5.918 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr1_-_52500679 3.919 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr3_+_102734496 3.880 ENSMUST00000029451.5
 Tspan2
tetraspanin 2
chr5_+_32136458 2.987 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr4_+_116221689 2.518 ENSMUST00000106490.2
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_+_68861564 2.416 ENSMUST00000176018.1
 Cers6
ceramide synthase 6
chr4_+_116221590 2.354 ENSMUST00000147292.1
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr6_+_50110837 2.212 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr18_-_62741387 2.183 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr4_+_116221633 2.070 ENSMUST00000030464.7
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_-_172329261 2.023 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr11_-_84068766 2.005 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr2_+_52857844 2.003 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr14_+_68083853 1.917 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr1_+_132316112 1.816 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr11_-_84068357 1.812 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr6_+_116264186 1.773 ENSMUST00000036503.7
ENSMUST00000112900.3
 Zfand4

zinc finger, AN1-type domain 4

chr17_+_3397189 1.663 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr6_+_15196949 1.612 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr2_+_68861433 1.544 ENSMUST00000028426.2
 Cers6
ceramide synthase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.5 5.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.3 3.9 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 3.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 3.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.4 GO:0003334 keratinocyte development(GO:0003334)
0.4 2.2 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 2.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.1 2.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.6 1.9 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 1.9 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 1.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 1.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.5 1.4 GO:0033364 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) mast cell secretory granule organization(GO:0033364)
0.5 1.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.3 1.4 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 1.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.4 1.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 5.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.0 GO:0043209 myelin sheath(GO:0043209)
0.1 2.3 GO:0043034 costamere(GO:0043034)
0.0 2.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.6 1.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.3 1.0 GO:0002141 stereocilia ankle link(GO:0002141)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.2 5.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 4.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 3.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 2.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 1.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 0.8 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.2 0.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)