Motif ID: Evx2

Z-value: 1.011


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_17402672 3.446 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr2_+_154548888 2.730 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chrX_-_60893430 2.250 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_-_168767136 1.529 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr4_+_102570065 1.390 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_91256813 1.034 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr2_+_91257323 1.012 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr4_-_132075250 0.961 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr5_-_84417359 0.941 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr11_+_75532099 0.872 ENSMUST00000169547.2
 Slc43a2
solute carrier family 43, member 2
chr6_+_72097561 0.852 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr9_-_66514567 0.789 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr10_+_80264942 0.740 ENSMUST00000105362.1
ENSMUST00000105361.3
 Dazap1

DAZ associated protein 1

chr2_-_132247747 0.740 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr12_-_98577940 0.731 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr16_-_45724600 0.708 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr14_+_48446128 0.693 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr9_+_47530173 0.677 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr11_+_116843278 0.676 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr17_+_36837123 0.670 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chr4_+_100478806 0.619 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr5_-_98030727 0.614 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr1_-_184999549 0.538 ENSMUST00000027929.4
 Mark1
MAP/microtubule affinity-regulating kinase 1
chr2_-_168767029 0.536 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr2_-_155074447 0.499 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chr17_-_47834682 0.479 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr7_-_44257378 0.476 ENSMUST00000107945.1
ENSMUST00000118216.1
 Acpt

acid phosphatase, testicular

chr10_-_128525859 0.453 ENSMUST00000026427.6
 Esyt1
extended synaptotagmin-like protein 1
chr4_-_42661893 0.432 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr19_+_5088534 0.402 ENSMUST00000025811.4
 Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_+_60537978 0.381 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr2_+_119047129 0.342 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr18_-_24603791 0.328 ENSMUST00000070726.3
 Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr14_-_59365410 0.324 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr4_+_109978004 0.323 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_-_124779686 0.317 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr19_+_41933464 0.311 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr2_-_150255591 0.307 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr2_+_119047116 0.293 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr7_+_29816061 0.285 ENSMUST00000032796.6
ENSMUST00000178162.1
 Zfp790

zinc finger protein 790

chr18_-_88927447 0.280 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr4_-_132345715 0.280 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr14_+_73173825 0.278 ENSMUST00000166875.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr19_+_47067721 0.273 ENSMUST00000026027.5
 Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_+_39612934 0.263 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr1_-_134955908 0.262 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
 Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr8_+_92855319 0.251 ENSMUST00000046290.1
 Lpcat2
lysophosphatidylcholine acyltransferase 2
chr12_+_109545390 0.246 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr18_-_24603464 0.228 ENSMUST00000154205.1
 Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr3_+_121291725 0.219 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr4_-_132345686 0.200 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr11_-_61267177 0.194 ENSMUST00000066277.3
ENSMUST00000074127.7
ENSMUST00000108715.2
 Aldh3a2


aldehyde dehydrogenase family 3, subfamily A2


chrM_+_10167 0.194 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr1_-_24612700 0.193 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr16_-_42340595 0.192 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chrX_-_111536325 0.182 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr4_+_140701466 0.176 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr1_-_134955847 0.164 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr10_-_80701811 0.152 ENSMUST00000003438.9
 Mob3a
MOB kinase activator 3A
chr6_-_69284319 0.138 ENSMUST00000103349.1
 Igkv4-69
immunoglobulin kappa variable 4-69
chr3_-_130709419 0.135 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr15_+_34453285 0.132 ENSMUST00000060894.7
 BC030476
cDNA sequence BC030476
chr12_+_52699297 0.131 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr6_-_69400097 0.129 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chr7_-_143460989 0.103 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_120378692 0.074 ENSMUST00000026448.9
 2310003H01Rik
RIKEN cDNA 2310003H01 gene
chr8_-_31168699 0.069 ENSMUST00000033983.4
 Mak16
MAK16 homolog (S. cerevisiae)
chr3_+_94837702 0.058 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr3_+_94837533 0.051 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr2_-_27475622 0.032 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
 Brd3


bromodomain containing 3


chr7_-_126800354 0.021 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr8_+_113635550 0.017 ENSMUST00000179926.1
 Mon1b
MON1 homolog b (yeast)
chr8_-_35495487 0.004 ENSMUST00000033927.6
 Eri1
exoribonuclease 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 3.4 GO:0097352 autophagosome maturation(GO:0097352)
0.1 2.2 GO:0007530 sex determination(GO:0007530)
0.1 2.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 2.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.3 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.2 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.0 0.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.3 GO:0001783 B cell apoptotic process(GO:0001783)
0.0 0.8 GO:0015807 L-amino acid transport(GO:0015807)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033503 HULC complex(GO:0033503)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 2.1 GO:0000792 heterochromatin(GO:0000792)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.7 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0031672 A band(GO:0031672)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.9 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.4 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 1.4 GO:0030552 cAMP binding(GO:0030552)
0.0 0.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)