Motif ID: Six4

Z-value: 0.482


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.039.2e-01Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66831625 1.136 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_+_13590402 0.853 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr6_+_149130170 0.726 ENSMUST00000087348.3
 Gm10203
predicted gene 10203
chr13_-_76385028 0.674 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr15_+_92051153 0.641 ENSMUST00000169825.1
 Cntn1
contactin 1
chr12_-_41485751 0.620 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chr7_+_38183787 0.606 ENSMUST00000067854.8
ENSMUST00000177983.1
 1600014C10Rik

RIKEN cDNA 1600014C10 gene

chr17_-_48409729 0.564 ENSMUST00000160319.1
ENSMUST00000159535.1
ENSMUST00000078800.6
ENSMUST00000046719.7
ENSMUST00000162460.1
 Nfya




nuclear transcription factor-Y alpha




chr7_+_29309429 0.555 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr2_-_103797617 0.543 ENSMUST00000028607.6
 Caprin1
cell cycle associated protein 1
chr15_+_65787023 0.468 ENSMUST00000015146.9
ENSMUST00000173858.1
ENSMUST00000172756.1
ENSMUST00000174856.1
 Efr3a



EFR3 homolog A (S. cerevisiae)



chr7_+_29307924 0.441 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr1_-_78968079 0.431 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr3_+_40950631 0.423 ENSMUST00000048490.6
 Larp1b
La ribonucleoprotein domain family, member 1B
chr6_+_50110186 0.415 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
 Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr7_-_143460989 0.412 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr13_+_73626886 0.411 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr7_-_132317198 0.387 ENSMUST00000080215.5
 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr13_+_54071815 0.363 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr12_+_75818294 0.346 ENSMUST00000143031.1
ENSMUST00000044217.9
ENSMUST00000150317.1
 Syne2


spectrin repeat containing, nuclear envelope 2


chr2_-_104493690 0.346 ENSMUST00000111124.1
 Hipk3
homeodomain interacting protein kinase 3
chr2_-_93452679 0.341 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr1_-_37890333 0.332 ENSMUST00000139725.1
ENSMUST00000027257.8
 Mitd1

MIT, microtubule interacting and transport, domain containing 1

chr16_+_11405648 0.278 ENSMUST00000096273.2
 Snx29
sorting nexin 29
chr2_-_10048580 0.269 ENSMUST00000026888.4
 Taf3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_+_6400523 0.206 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr2_-_91444622 0.202 ENSMUST00000064652.7
ENSMUST00000102594.4
ENSMUST00000094835.2
 1110051M20Rik


RIKEN cDNA 1110051M20 gene


chr11_+_3989924 0.173 ENSMUST00000109981.1
 Gal3st1
galactose-3-O-sulfotransferase 1
chr3_-_30969399 0.170 ENSMUST00000177992.1
ENSMUST00000129817.2
ENSMUST00000168645.1
ENSMUST00000108255.1
ENSMUST00000064718.5
ENSMUST00000099163.3
 Phc3





polyhomeotic-like 3 (Drosophila)





chr15_-_79834224 0.158 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
 Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr12_-_21417356 0.139 ENSMUST00000103002.1
 Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr2_+_131133497 0.115 ENSMUST00000110225.1
 Gm11037
predicted gene 11037
chr1_+_37890477 0.107 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr19_+_6400611 0.103 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr6_-_23248264 0.101 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_67078293 0.096 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr8_-_84237042 0.090 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr18_+_60212080 0.088 ENSMUST00000031549.5
 Gm4951
predicted gene 4951
chrX_-_139714481 0.083 ENSMUST00000183728.1
 Gm15013
predicted gene 15013
chr3_+_145938004 0.072 ENSMUST00000039571.7
 2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr1_-_180813591 0.068 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr1_-_180813534 0.065 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr3_-_129831374 0.065 ENSMUST00000029643.8
 Gar1
GAR1 ribonucleoprotein homolog (yeast)
chr6_-_72380416 0.062 ENSMUST00000101285.3
ENSMUST00000074231.3
 Vamp5

vesicle-associated membrane protein 5

chr7_+_28180272 0.061 ENSMUST00000173223.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr19_+_8764934 0.054 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr7_+_28180226 0.050 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr12_-_57546121 0.048 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr6_+_124931378 0.045 ENSMUST00000032214.7
ENSMUST00000180095.1
 Mlf2

myeloid leukemia factor 2

chr15_-_79834261 0.044 ENSMUST00000148358.1
 Cbx6
chromobox 6
chr4_-_134018829 0.043 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr8_+_95703037 0.036 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr8_+_94214567 0.027 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr8_-_85067982 0.025 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr10_-_80918212 0.020 ENSMUST00000057623.7
ENSMUST00000179022.1
 Lmnb2

lamin B2

chr9_-_70503718 0.014 ENSMUST00000034739.5
 Rnf111
ring finger 111
chrX_-_150440887 0.014 ENSMUST00000163233.1
 Tmem29
transmembrane protein 29
chr13_-_93674300 0.010 ENSMUST00000015941.7
 Bhmt2
betaine-homocysteine methyltransferase 2
chr5_-_145191511 0.003 ENSMUST00000161845.1
 Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0033364 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.4 GO:0060065 uterus development(GO:0060065)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.6 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.5 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001533 cornified envelope(GO:0001533)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0001221 transcription cofactor binding(GO:0001221)