Motif ID: Foxd3

Z-value: 0.664


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_144209471 3.243 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 3.208 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chrX_+_164373363 1.710 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr14_-_70630149 1.413 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr6_+_77242644 1.347 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 1.307 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr4_-_82850721 1.291 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr1_-_126830786 1.242 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr13_+_16014457 1.237 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr1_-_126830632 1.109 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr11_+_98798653 1.078 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr15_+_92597104 1.049 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr11_+_83302817 0.847 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr15_+_100154379 0.797 ENSMUST00000023768.6
ENSMUST00000108971.2
 Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr8_-_87959560 0.790 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr10_-_19011948 0.785 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr2_-_45110336 0.749 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr5_+_148265202 0.728 ENSMUST00000110515.2
 Mtus2
microtubule associated tumor suppressor candidate 2
chr17_+_28691419 0.724 ENSMUST00000124886.1
 Mapk14
mitogen-activated protein kinase 14
chr5_-_88675190 0.717 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr4_+_115737754 0.711 ENSMUST00000106522.2
 Efcab14
EF-hand calcium binding domain 14
chr10_-_127030789 0.710 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr4_-_36056726 0.703 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr5_+_148265307 0.610 ENSMUST00000110514.1
 Mtus2
microtubule associated tumor suppressor candidate 2
chr2_-_120539852 0.600 ENSMUST00000171215.1
 Zfp106
zinc finger protein 106
chr5_+_148265265 0.599 ENSMUST00000071878.5
 Mtus2
microtubule associated tumor suppressor candidate 2
chr16_+_13986596 0.527 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
 2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr10_-_127030813 0.487 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr4_+_115737738 0.455 ENSMUST00000106525.2
 Efcab14
EF-hand calcium binding domain 14
chr10_-_11080956 0.413 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr2_+_152669461 0.412 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
 H13



histocompatibility 13



chr10_+_93488766 0.364 ENSMUST00000129421.1
 Hal
histidine ammonia lyase
chr9_+_54980880 0.362 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr14_-_52213379 0.361 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr18_+_37513652 0.355 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr10_+_11609256 0.354 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr14_-_93888732 0.315 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr11_-_107189325 0.306 ENSMUST00000018577.7
ENSMUST00000106757.1
 Nol11

nucleolar protein 11

chr1_-_170867761 0.304 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr10_-_88605017 0.300 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr17_+_29090969 0.257 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_9882622 0.240 ENSMUST00000114919.1
 4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr1_+_6734827 0.232 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr14_+_101840501 0.227 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr9_+_105642957 0.211 ENSMUST00000065778.6
 Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr17_+_93199348 0.208 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr9_+_36832684 0.203 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr4_+_108847827 0.189 ENSMUST00000102738.2
 Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr5_-_31295862 0.187 ENSMUST00000041266.7
ENSMUST00000172435.1
 Fndc4

fibronectin type III domain containing 4

chr9_-_20879718 0.173 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr2_+_14388434 0.160 ENSMUST00000133258.1
 Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr4_-_137785371 0.155 ENSMUST00000133473.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr1_+_134415414 0.146 ENSMUST00000112237.1
 Adipor1
adiponectin receptor 1
chr12_+_111971545 0.146 ENSMUST00000079009.5
 Tdrd9
tudor domain containing 9
chr5_-_120612558 0.133 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
 1110008J03Rik


RIKEN cDNA 1110008J03 gene


chr9_-_90270712 0.090 ENSMUST00000041767.7
ENSMUST00000144348.1
 Tbc1d2b

TBC1 domain family, member 2B

chr19_+_8953826 0.072 ENSMUST00000096239.5
 Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr6_-_3494587 0.071 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr17_+_28691342 0.041 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
 Mapk14



mitogen-activated protein kinase 14



chr12_-_110840905 0.021 ENSMUST00000177224.1
ENSMUST00000084974.4
ENSMUST00000070565.8
 Stk30


serine/threonine kinase 30



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.5 1.4 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.3 0.8 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.2 1.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 1.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.8 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.7 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 2.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.4 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.5 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration(GO:0021814)
0.1 0.2 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.1 0.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 1.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.3 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.0 0.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.8 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.4 1.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.1 GO:0072487 MSL complex(GO:0072487)
0.1 0.3 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.4 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.4 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 6.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.0 GO:0030426 growth cone(GO:0030426)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.8 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.4 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 2.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.4 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889) acetylcholine binding(GO:0042166)
0.0 2.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.8 GO:0030276 clathrin binding(GO:0030276)
0.0 6.8 GO:0046982 protein heterodimerization activity(GO:0046982)