Motif ID: Hes5_Hes7

Z-value: 0.937

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes7mm10_v2_chr11_+_69120404_69120404-0.401.6e-01Click!
Hes5mm10_v2_chr4_+_154960915_154960930-0.283.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12026732 7.381 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026237 4.647 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr13_+_51846673 2.461 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr12_+_109549157 1.360 ENSMUST00000128458.1
ENSMUST00000150851.1
Meg3

maternally expressed 3

chrX_+_8271133 1.087 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5

solute carrier family 38, member 5

chr8_-_87804411 1.067 ENSMUST00000165770.2
Zfp423
zinc finger protein 423
chr5_+_31251678 0.943 ENSMUST00000054829.7
ENSMUST00000114570.1
ENSMUST00000075611.7
Krtcap3


keratinocyte associated protein 3


chr3_+_104638658 0.812 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr11_-_109722214 0.741 ENSMUST00000020938.7
Fam20a
family with sequence similarity 20, member A
chr18_-_46280820 0.712 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr4_-_149126688 0.673 ENSMUST00000030815.2
Cort
cortistatin
chr15_-_32244632 0.631 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr15_+_72913357 0.631 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chr15_+_32244801 0.584 ENSMUST00000067458.6
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr5_-_45857473 0.578 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl


ligand dependent nuclear receptor corepressor-like


chr14_+_31019125 0.565 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
Pbrm1



polybromo 1



chr1_-_193035651 0.485 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr9_+_45117813 0.452 ENSMUST00000170998.1
ENSMUST00000093855.3
Scn2b

sodium channel, voltage-gated, type II, beta

chr6_+_49319274 0.433 ENSMUST00000055559.7
ENSMUST00000114491.1
Ccdc126

coiled-coil domain containing 126

chr14_+_59201209 0.409 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1


chr9_+_46012822 0.380 ENSMUST00000120463.2
ENSMUST00000120247.1
Sik3

SIK family kinase 3

chr1_+_131962941 0.375 ENSMUST00000177943.1
Slc45a3
solute carrier family 45, member 3
chr14_+_59201418 0.351 ENSMUST00000140136.2
ENSMUST00000142326.1
Rcbtb1

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

chr6_+_72097561 0.335 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr11_+_4637734 0.329 ENSMUST00000109930.2
ENSMUST00000070257.7
Ascc2

activating signal cointegrator 1 complex subunit 2

chr8_+_124722139 0.325 ENSMUST00000034463.3
Arv1
ARV1 homolog (yeast)
chr14_-_33447142 0.322 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
Mapk8


mitogen-activated protein kinase 8


chr4_-_133756769 0.312 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr1_+_9908638 0.310 ENSMUST00000171802.1
ENSMUST00000052843.5
ENSMUST00000125294.2
ENSMUST00000140948.2
Mcmdc2



minichromosome maintenance domain containing 2



chr1_+_72824482 0.301 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr14_+_31019159 0.301 ENSMUST00000112094.1
ENSMUST00000144009.1
Pbrm1

polybromo 1

chr15_+_39076885 0.285 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr10_+_79682169 0.269 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr8_-_124721956 0.254 ENSMUST00000117624.1
ENSMUST00000041614.8
ENSMUST00000118134.1
Ttc13


tetratricopeptide repeat domain 13


chr17_+_35861318 0.241 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr14_+_31019183 0.227 ENSMUST00000052239.5
Pbrm1
polybromo 1
chr1_-_161876656 0.216 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chr3_-_95855860 0.215 ENSMUST00000015892.7
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr10_+_36974536 0.213 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr6_+_83165920 0.211 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
Dctn1


dynactin 1


chr1_+_193173469 0.204 ENSMUST00000161235.1
ENSMUST00000110831.2
ENSMUST00000178744.1
A130010J15Rik


RIKEN cDNA A130010J15 gene


chr3_-_95855753 0.202 ENSMUST00000161476.1
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr11_+_59306920 0.201 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr2_+_91526756 0.186 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr2_-_102400863 0.180 ENSMUST00000102573.1
Trim44
tripartite motif-containing 44
chrX_-_9256899 0.180 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr2_-_146511899 0.178 ENSMUST00000131824.1
Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr5_+_141241490 0.170 ENSMUST00000085774.4
Sdk1
sidekick homolog 1 (chicken)
chr8_-_125898291 0.167 ENSMUST00000047239.6
Pcnxl2
pecanex-like 2 (Drosophila)
chr11_+_117654211 0.162 ENSMUST00000026658.6
Tnrc6c
trinucleotide repeat containing 6C
chr7_+_44384803 0.161 ENSMUST00000120262.1
Syt3
synaptotagmin III
chr2_-_130424242 0.151 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr11_+_70844745 0.147 ENSMUST00000076270.6
ENSMUST00000179114.1
ENSMUST00000100928.4
ENSMUST00000177731.1
ENSMUST00000108533.3
ENSMUST00000081362.6
ENSMUST00000178245.1
Rabep1






rabaptin, RAB GTPase binding effector protein 1






chr8_-_25754214 0.142 ENSMUST00000033975.6
Ddhd2
DDHD domain containing 2
chr19_+_47178820 0.141 ENSMUST00000111808.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr7_-_65370908 0.140 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr10_+_36974558 0.131 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr13_+_49653297 0.124 ENSMUST00000021824.7
Nol8
nucleolar protein 8
chr7_+_100706702 0.115 ENSMUST00000049053.7
Fam168a
family with sequence similarity 168, member A
chr17_+_56326045 0.111 ENSMUST00000139679.1
ENSMUST00000025036.4
ENSMUST00000086835.5
Kdm4b


lysine (K)-specific demethylase 4B


chr17_-_25273861 0.108 ENSMUST00000172868.1
ENSMUST00000172618.1
Ube2i

ubiquitin-conjugating enzyme E2I

chr3_-_88177671 0.107 ENSMUST00000181837.1
1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr11_-_96916366 0.103 ENSMUST00000144731.1
ENSMUST00000127048.1
Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr11_+_67025144 0.100 ENSMUST00000079077.5
ENSMUST00000061786.5
Tmem220

transmembrane protein 220

chr2_+_156065738 0.097 ENSMUST00000137966.1
Spag4
sperm associated antigen 4
chr2_+_29060239 0.094 ENSMUST00000100237.3
Ttf1
transcription termination factor, RNA polymerase I
chr4_+_154869585 0.094 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr3_+_90052814 0.093 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
4933434E20Rik



RIKEN cDNA 4933434E20 gene



chr6_+_4755327 0.090 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr6_+_71707561 0.085 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr4_-_43562397 0.084 ENSMUST00000030187.7
Tln1
talin 1
chr9_-_78443204 0.080 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1

Mab-21 domain containing 1

chr1_-_75219245 0.078 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr4_+_137913471 0.075 ENSMUST00000151110.1
Ece1
endothelin converting enzyme 1
chr4_-_123904826 0.073 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr10_+_79682304 0.073 ENSMUST00000166603.1
Cdc34
cell division cycle 34
chr10_-_57532416 0.072 ENSMUST00000169122.1
Serinc1
serine incorporator 1
chr4_+_123904832 0.070 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr17_-_24960620 0.069 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr10_-_57532489 0.063 ENSMUST00000020027.4
Serinc1
serine incorporator 1
chr2_-_146511992 0.056 ENSMUST00000109986.2
Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr6_+_91157373 0.054 ENSMUST00000155007.1
Hdac11
histone deacetylase 11
chr11_-_78165521 0.049 ENSMUST00000017530.3
Traf4
TNF receptor associated factor 4
chr7_-_131362687 0.048 ENSMUST00000059438.9
2310057M21Rik
RIKEN cDNA 2310057M21 gene
chr5_-_99729039 0.041 ENSMUST00000146396.1
ENSMUST00000161148.1
ENSMUST00000161516.1
A930011G23Rik


RIKEN cDNA A930011G23 gene


chr3_-_90052463 0.038 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr2_-_155692317 0.036 ENSMUST00000103140.4
Trpc4ap
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr7_+_100706623 0.033 ENSMUST00000107042.1
Fam168a
family with sequence similarity 168, member A
chr16_-_45724600 0.032 ENSMUST00000096057.4
Tagln3
transgelin 3
chr2_-_155692376 0.025 ENSMUST00000041059.5
Trpc4ap
transient receptor potential cation channel, subfamily C, member 4 associated protein
chr15_+_102073773 0.020 ENSMUST00000169681.1
Eif4b
eukaryotic translation initiation factor 4B
chr12_+_109459843 0.016 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr4_+_123904907 0.006 ENSMUST00000106202.3
Mycbp
c-myc binding protein
chr8_+_106603351 0.004 ENSMUST00000000312.5
ENSMUST00000167688.1
Cdh1

cadherin 1


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 12.0 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 1.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 2.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 0.7 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.7 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 1.1 GO:0015816 glycine transport(GO:0015816)
0.1 0.4 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.3 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.1 0.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 1.4 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.2 GO:0060178 regulation of exocyst localization(GO:0060178)
0.0 0.7 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.3 GO:0032366 intracellular sterol transport(GO:0032366)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0007288 sperm axoneme assembly(GO:0007288) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169) regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:0032402 melanosome transport(GO:0032402)
0.0 0.4 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.4 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.3 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.7 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.3 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.1 0.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)