Motif ID: Hes5_Hes7

Z-value: 0.937

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes7mm10_v2_chr11_+_69120404_69120404-0.401.6e-01Click!
Hes5mm10_v2_chr4_+_154960915_154960930-0.283.4e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026732 7.381 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026237 4.647 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr13_+_51846673 2.461 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr12_+_109549157 1.360 ENSMUST00000128458.1
ENSMUST00000150851.1
 Meg3

maternally expressed 3

chrX_+_8271133 1.087 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr8_-_87804411 1.067 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr5_+_31251678 0.943 ENSMUST00000054829.7
ENSMUST00000114570.1
ENSMUST00000075611.7
 Krtcap3


keratinocyte associated protein 3


chr3_+_104638658 0.812 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr11_-_109722214 0.741 ENSMUST00000020938.7
 Fam20a
family with sequence similarity 20, member A
chr18_-_46280820 0.712 ENSMUST00000025354.3
 Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr4_-_149126688 0.673 ENSMUST00000030815.2
 Cort
cortistatin
chr15_-_32244632 0.631 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr15_+_72913357 0.631 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr15_+_32244801 0.584 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr5_-_45857473 0.578 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr14_+_31019125 0.565 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
 Pbrm1



polybromo 1



chr1_-_193035651 0.485 ENSMUST00000016344.7
 Syt14
synaptotagmin XIV
chr9_+_45117813 0.452 ENSMUST00000170998.1
ENSMUST00000093855.3
 Scn2b

sodium channel, voltage-gated, type II, beta

chr6_+_49319274 0.433 ENSMUST00000055559.7
ENSMUST00000114491.1
 Ccdc126

coiled-coil domain containing 126

chr14_+_59201209 0.409 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
 Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 12.0 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 2.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.1 1.4 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 1.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.1 1.1 GO:0015816 glycine transport(GO:0015816)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.7 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.7 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.0 0.7 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.4 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.4 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.1 0.3 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.1 0.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.3 GO:0032366 intracellular sterol transport(GO:0032366)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.7 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.1 0.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.3 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0004806 triglyceride lipase activity(GO:0004806)