Motif ID: Lhx4
Z-value: 1.410
Transcription factors associated with Lhx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Lhx4 | ENSMUSG00000026468.8 | Lhx4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.4 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 3.1 | 9.3 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 2.3 | 11.7 | GO:0002024 | diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845) |
| 1.6 | 21.4 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 1.3 | 3.8 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 1.3 | 5.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.0 | 4.2 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.8 | 12.5 | GO:1902993 | positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.8 | 1.6 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
| 0.7 | 3.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.7 | 3.3 | GO:0001661 | conditioned taste aversion(GO:0001661) amygdala development(GO:0021764) |
| 0.6 | 1.9 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.4 | 2.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.4 | 0.4 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) oxidative demethylation(GO:0070989) |
| 0.3 | 1.0 | GO:0060023 | soft palate development(GO:0060023) |
| 0.3 | 4.2 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.3 | 0.9 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.3 | 1.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.3 | 1.1 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.3 | 1.3 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.2 | 4.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.2 | 1.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 0.9 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 3.2 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.2 | 0.7 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.2 | 0.5 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.2 | 1.9 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.2 | 1.3 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.2 | 0.5 | GO:0090298 | negative regulation of mitochondrial DNA replication(GO:0090298) |
| 0.2 | 0.8 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.2 | 2.7 | GO:0080111 | DNA demethylation(GO:0080111) |
| 0.1 | 0.9 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 0.9 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 2.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 0.4 | GO:0008594 | photoreceptor cell morphogenesis(GO:0008594) |
| 0.1 | 0.5 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 0.3 | GO:2000790 | regulation of mesenchymal cell proliferation involved in lung development(GO:2000790) negative regulation of mesenchymal cell proliferation involved in lung development(GO:2000791) |
| 0.1 | 1.9 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 0.4 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 0.6 | GO:0051661 | maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684) |
| 0.1 | 1.0 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.1 | 0.5 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.1 | 4.7 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.1 | 0.4 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) endocardial cushion to mesenchymal transition(GO:0090500) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 0.3 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.1 | 1.8 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 0.7 | GO:1904017 | positive regulation of female receptivity(GO:0045925) response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.1 | 0.7 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.1 | 0.3 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 4.0 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.1 | 0.6 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 0.7 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.1 | 0.9 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 0.3 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
| 0.1 | 2.2 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.1 | 0.3 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 1.0 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 0.9 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.1 | 0.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 0.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 6.3 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 2.4 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.1 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.0 | 1.3 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 0.9 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.0 | 0.3 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.0 | 0.1 | GO:2000334 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.0 | 0.5 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.8 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.0 | 0.1 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.0 | 0.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.4 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.8 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.0 | 0.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.0 | GO:0010288 | response to lead ion(GO:0010288) |
| 0.0 | 0.4 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.0 | 0.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.1 | GO:0002021 | response to dietary excess(GO:0002021) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.8 | GO:0060187 | cell pole(GO:0060187) |
| 0.5 | 21.4 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.5 | 4.7 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.4 | 1.3 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.3 | 5.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 1.3 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 0.8 | GO:0097413 | Lewy body(GO:0097413) |
| 0.2 | 4.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 2.6 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 0.5 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 1.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 2.2 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 1.2 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 1.9 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 0.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 9.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 9.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.4 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 11.7 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.7 | 4.0 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.6 | 3.0 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.6 | 24.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.5 | 1.6 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
| 0.4 | 0.9 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.4 | 5.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.3 | 1.3 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.3 | 0.9 | GO:0031779 | melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) |
| 0.3 | 0.9 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.3 | 1.9 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.3 | 0.8 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.2 | 1.9 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.2 | 0.5 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.2 | 5.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 1.1 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.1 | 2.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.8 | GO:0016594 | glycine binding(GO:0016594) |
| 0.1 | 3.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 4.2 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 7.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.0 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.1 | 12.7 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 0.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.4 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 0.3 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.1 | 1.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 1.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.1 | 0.5 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.5 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 0.8 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 2.3 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.1 | 0.4 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 0.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 4.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.1 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
| 0.0 | 2.0 | GO:0044824 | integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824) |
| 0.0 | 1.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.3 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
| 0.0 | 0.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 0.3 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 4.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.2 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 11.0 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 0.9 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.5 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 1.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.2 | GO:0042556 | cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 0.4 | GO:0016415 | octanoyltransferase activity(GO:0016415) |
