Motif ID: Lhx4

Z-value: 1.410


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 11.738 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr1_+_153665666 9.450 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr15_-_93595877 9.320 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr16_-_22161450 6.540 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr10_-_64090241 6.409 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_+_153665587 6.320 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr10_-_64090265 6.041 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_+_153665627 5.617 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr9_+_118478182 5.259 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 5.158 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr17_+_17402672 4.805 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr4_+_102589687 4.215 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_75455957 4.151 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr10_-_63927434 4.108 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr15_-_64922290 3.953 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr7_+_66839726 3.883 ENSMUST00000098382.3
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr7_+_66839752 3.776 ENSMUST00000107478.1
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr2_+_61804453 3.265 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr6_+_96115249 3.251 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr8_-_109251698 3.026 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 21.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.8 12.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
2.3 11.7 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
3.5 10.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.1 9.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 6.3 GO:0051028 mRNA transport(GO:0051028)
1.3 5.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 4.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 4.7 GO:0016601 Rac protein signal transduction(GO:0016601)
1.0 4.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 4.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 4.0 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.3 3.8 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.7 3.3 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.2 3.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.7 3.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 2.7 GO:0080111 DNA demethylation(GO:0080111)
0.0 2.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.4 2.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 2.2 GO:0070986 left/right axis specification(GO:0070986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 9.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 9.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 5.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.5 4.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 4.2 GO:0000930 gamma-tubulin complex(GO:0000930)
1.0 3.8 GO:0060187 cell pole(GO:0060187)
0.1 2.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 2.2 GO:0097440 apical dendrite(GO:0097440)
0.1 1.9 GO:0043034 costamere(GO:0043034)
0.1 1.6 GO:0001891 phagocytic cup(GO:0001891)
0.4 1.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 1.3 GO:0031523 Myb complex(GO:0031523)
0.1 1.2 GO:0010369 chromocenter(GO:0010369)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.8 GO:0097413 Lewy body(GO:0097413)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 12.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
3.9 11.7 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 11.0 GO:0008134 transcription factor binding(GO:0008134)
0.1 7.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 5.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 5.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.2 GO:0030552 cAMP binding(GO:0030552)
0.0 4.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.7 4.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 3.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 3.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 2.0 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.3 1.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.8 GO:0016594 glycine binding(GO:0016594)
0.5 1.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)