Motif ID: Foxc2

Z-value: 0.509


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.146.3e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53850243 0.522 ENSMUST00000048485.5
 Sln
sarcolipin
chr10_-_61979073 0.507 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr1_-_156034826 0.468 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr19_-_58455903 0.460 ENSMUST00000131877.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr18_-_47333311 0.450 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr18_-_74961252 0.443 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr8_-_84773381 0.387 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr18_+_61105561 0.362 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr19_-_58455161 0.359 ENSMUST00000135730.1
ENSMUST00000152507.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr13_+_40859768 0.352 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr10_-_68278713 0.299 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr19_-_58455398 0.260 ENSMUST00000026076.7
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr9_+_70207342 0.253 ENSMUST00000034745.7
 Myo1e
myosin IE
chr11_+_98446826 0.232 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr2_-_51972990 0.228 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr18_-_54990124 0.223 ENSMUST00000064763.5
 Zfp608
zinc finger protein 608
chr14_+_48120841 0.221 ENSMUST00000073150.4
 Peli2
pellino 2
chr4_+_102430047 0.219 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_65529275 0.215 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr8_-_64205970 0.213 ENSMUST00000066166.4
 Tll1
tolloid-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.5 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.4 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.3 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.3 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.3 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.3 GO:0060613 fat pad development(GO:0060613)
0.1 0.2 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.2 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.2 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0009404 toxin metabolic process(GO:0009404)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0016015 morphogen activity(GO:0016015)
0.1 0.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)