Motif ID: Nr2c1

Z-value: 0.436


Transcription factors associated with Nr2c1:

Gene SymbolEntrez IDGene Name
Nr2c1 ENSMUSG00000005897.8 Nr2c1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_941480230.156.1e-01Click!


Activity profile for motif Nr2c1.

activity profile for motif Nr2c1


Sorted Z-values histogram for motif Nr2c1

Sorted Z-values for motif Nr2c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_107631322 0.849 ENSMUST00000106703.1
Gm10961
predicted gene 10961
chr2_-_54085542 0.391 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr13_-_9878998 0.364 ENSMUST00000063093.9
Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr1_+_133309778 0.343 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr1_+_59256906 0.326 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr3_+_96830069 0.304 ENSMUST00000058865.7
Pdzk1
PDZ domain containing 1
chr15_-_89425795 0.303 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr7_+_45896941 0.296 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr12_+_61523889 0.272 ENSMUST00000119481.1
ENSMUST00000055815.7
Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr16_-_4523056 0.252 ENSMUST00000090500.3
ENSMUST00000023161.7
Srl

sarcalumenin

chr2_-_112480817 0.240 ENSMUST00000099589.2
Chrm5
cholinergic receptor, muscarinic 5
chr2_+_164805082 0.236 ENSMUST00000052107.4
Zswim3
zinc finger SWIM-type containing 3
chr4_+_117251951 0.226 ENSMUST00000062824.5
Tmem53
transmembrane protein 53
chr11_+_75193783 0.220 ENSMUST00000102514.3
Rtn4rl1
reticulon 4 receptor-like 1
chr4_+_117252010 0.216 ENSMUST00000125943.1
ENSMUST00000106434.1
Tmem53

transmembrane protein 53

chr13_-_73328442 0.197 ENSMUST00000022097.5
Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr19_+_46152505 0.197 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr4_+_150853919 0.194 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr7_+_45897429 0.193 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr8_-_123894736 0.189 ENSMUST00000034453.4
Acta1
actin, alpha 1, skeletal muscle
chr11_-_115808068 0.186 ENSMUST00000132780.1
Caskin2
CASK-interacting protein 2
chr10_-_86498836 0.175 ENSMUST00000120638.1
Syn3
synapsin III
chr2_-_30830333 0.169 ENSMUST00000041726.3
Asb6
ankyrin repeat and SOCS box-containing 6
chr11_-_64079444 0.169 ENSMUST00000049091.8
Cox10
cytochrome c oxidase assembly protein 10
chr10_-_93589621 0.165 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr7_+_30232032 0.149 ENSMUST00000149654.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr15_+_25773985 0.147 ENSMUST00000125667.1
Myo10
myosin X
chr5_-_5265224 0.145 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr3_-_32365608 0.140 ENSMUST00000168566.1
Zmat3
zinc finger matrin type 3
chr7_+_30232310 0.139 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr1_-_58973421 0.131 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2

trafficking protein, kinesin binding 2

chr19_+_4097392 0.129 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr10_+_93589413 0.126 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr3_-_32365643 0.124 ENSMUST00000029199.5
Zmat3
zinc finger matrin type 3
chr10_-_86498872 0.122 ENSMUST00000121789.1
Syn3
synapsin III
chr10_-_119240006 0.121 ENSMUST00000020315.6
Cand1
cullin associated and neddylation disassociated 1
chr11_-_97766508 0.120 ENSMUST00000107579.1
ENSMUST00000018685.2
Cwc25

CWC25 spliceosome-associated protein homolog (S. cerevisiae)

chr3_+_32529532 0.118 ENSMUST00000147350.1
Mfn1
mitofusin 1
chr1_-_155417283 0.117 ENSMUST00000027741.5
Xpr1
xenotropic and polytropic retrovirus receptor 1
chrX_-_12160355 0.113 ENSMUST00000043441.6
Bcor
BCL6 interacting corepressor
chr5_-_137741601 0.108 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr2_-_26237368 0.108 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr1_+_166254095 0.104 ENSMUST00000111416.1
Ildr2
immunoglobulin-like domain containing receptor 2
chr1_-_120120138 0.102 ENSMUST00000112648.1
ENSMUST00000128408.1
Dbi

diazepam binding inhibitor

chr13_+_31558157 0.101 ENSMUST00000042118.8
Foxq1
forkhead box Q1
chr12_+_4082574 0.101 ENSMUST00000020986.7
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr10_+_4432467 0.093 ENSMUST00000095893.4
ENSMUST00000118544.1
ENSMUST00000117489.1
1700052N19Rik


RIKEN cDNA 1700052N19 gene


chr7_+_46397648 0.091 ENSMUST00000160433.1
Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr10_-_4432312 0.087 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr1_+_58973521 0.086 ENSMUST00000114296.1
ENSMUST00000027185.4
Stradb

STE20-related kinase adaptor beta

chr4_-_11076160 0.084 ENSMUST00000058183.8
Ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr1_-_156939387 0.084 ENSMUST00000171292.1
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr17_-_46032366 0.080 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
Vegfa


vascular endothelial growth factor A


chr4_+_129461581 0.079 ENSMUST00000048162.8
ENSMUST00000138013.1
Bsdc1

BSD domain containing 1

chr4_+_133039482 0.078 ENSMUST00000105914.1
Ahdc1
AT hook, DNA binding motif, containing 1
chr4_-_41517326 0.078 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr19_-_6921753 0.078 ENSMUST00000173635.1
Esrra
estrogen related receptor, alpha
chr1_+_164115264 0.077 ENSMUST00000162746.1
Selp
selectin, platelet
chr17_-_35909626 0.077 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr4_-_129440800 0.076 ENSMUST00000053042.5
ENSMUST00000106046.1
Zbtb8b

zinc finger and BTB domain containing 8b

chr6_+_22875496 0.076 ENSMUST00000090568.3
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr9_-_60687459 0.075 ENSMUST00000114032.1
ENSMUST00000166168.1
ENSMUST00000132366.1
Lrrc49


leucine rich repeat containing 49


chr5_-_110779937 0.073 ENSMUST00000112426.1
Pus1
pseudouridine synthase 1
chr15_-_79505241 0.072 ENSMUST00000057801.6
Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
chr3_-_58525867 0.071 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr14_+_57798620 0.070 ENSMUST00000111268.1
Sap18
Sin3-associated polypeptide 18
chr1_+_74506044 0.069 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr3_-_107631681 0.068 ENSMUST00000064759.5
Strip1
striatin interacting protein 1
chr1_-_167285110 0.067 ENSMUST00000027839.8
Uck2
uridine-cytidine kinase 2
chr19_-_6921804 0.066 ENSMUST00000025906.4
Esrra
estrogen related receptor, alpha
chr14_+_57798637 0.066 ENSMUST00000111267.1
Sap18
Sin3-associated polypeptide 18
chr17_+_34850373 0.066 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr9_-_50659780 0.062 ENSMUST00000034567.3
Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr10_+_59395632 0.062 ENSMUST00000092511.4
Gm10273
predicted pseudogene 10273
chr15_-_98093245 0.062 ENSMUST00000180657.1
Senp1
SUMO1/sentrin specific peptidase 1
chr17_-_35910032 0.061 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
Atat1




alpha tubulin acetyltransferase 1




chr6_-_142964404 0.060 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr10_+_94147982 0.059 ENSMUST00000105290.2
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr11_+_4986824 0.058 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr1_+_58586381 0.058 ENSMUST00000027193.8
Ndufb3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3
chr3_+_68572245 0.054 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr16_-_44139630 0.053 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr12_+_37241633 0.048 ENSMUST00000049874.7
Agmo
alkylglycerol monooxygenase
chr7_+_108934405 0.046 ENSMUST00000033342.6
Eif3f
eukaryotic translation initiation factor 3, subunit F
chr6_+_125145235 0.042 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1



intermediate filament family orphan 1



chr4_+_131873608 0.042 ENSMUST00000053819.3
Srsf4
serine/arginine-rich splicing factor 4
chr19_-_45998479 0.039 ENSMUST00000045396.7
9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr12_-_83487708 0.039 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr1_-_74544275 0.038 ENSMUST00000044260.4
Usp37
ubiquitin specific peptidase 37
chr2_+_153345809 0.038 ENSMUST00000109790.1
Asxl1
additional sex combs like 1
chr9_-_14614949 0.037 ENSMUST00000013220.6
ENSMUST00000160770.1
Amotl1

angiomotin-like 1

chr2_+_106695594 0.034 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr1_-_156718894 0.032 ENSMUST00000086153.6
Fam20b
family with sequence similarity 20, member B
chr1_+_180726019 0.031 ENSMUST00000027780.4
Acbd3
acyl-Coenzyme A binding domain containing 3
chr11_-_76577701 0.030 ENSMUST00000176179.1
Abr
active BCR-related gene
chr1_-_156718989 0.030 ENSMUST00000122424.1
Fam20b
family with sequence similarity 20, member B
chr2_+_22895583 0.026 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr8_+_95825353 0.026 ENSMUST00000074053.4
Gm10094
predicted gene 10094
chr10_+_127705170 0.026 ENSMUST00000079590.5
Myo1a
myosin IA
chr7_+_82648595 0.023 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
Eftud1


elongation factor Tu GTP binding domain containing 1


chr10_-_67548944 0.022 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr2_-_164804876 0.021 ENSMUST00000103094.4
ENSMUST00000017451.6
Acot8

acyl-CoA thioesterase 8

chr2_-_29253001 0.020 ENSMUST00000071201.4
Ntng2
netrin G2
chr9_-_29412204 0.019 ENSMUST00000115237.1
Ntm
neurotrimin
chr8_+_119394866 0.019 ENSMUST00000098367.4
Mlycd
malonyl-CoA decarboxylase
chr4_+_118429701 0.019 ENSMUST00000067896.3
Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr7_+_80186835 0.018 ENSMUST00000107383.1
ENSMUST00000032754.7
Sema4b

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

chr11_-_26210553 0.017 ENSMUST00000101447.3
5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr14_+_20674311 0.017 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr19_-_3912711 0.016 ENSMUST00000075092.6
Ndufs8
NADH dehydrogenase (ubiquinone) Fe-S protein 8
chrX_-_102189371 0.015 ENSMUST00000033683.7
Rps4x
ribosomal protein S4, X-linked
chr2_+_79707780 0.015 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr5_-_110780569 0.015 ENSMUST00000149208.1
ENSMUST00000031483.8
ENSMUST00000086643.5
ENSMUST00000170468.1
ENSMUST00000031481.6
Pus1




pseudouridine synthase 1




chr15_+_80091320 0.013 ENSMUST00000009728.6
ENSMUST00000009727.5
Syngr1

synaptogyrin 1

chr17_-_12992227 0.012 ENSMUST00000007007.7
Wtap
Wilms' tumour 1-associating protein
chr15_-_93336800 0.009 ENSMUST00000080299.6
Yaf2
YY1 associated factor 2
chr11_-_50325599 0.007 ENSMUST00000179865.1
ENSMUST00000020637.8
Canx

calnexin

chr3_+_95318782 0.007 ENSMUST00000139866.1
Cers2
ceramide synthase 2
chr3_+_129213920 0.006 ENSMUST00000042587.10
Pitx2
paired-like homeodomain transcription factor 2
chr3_+_58526303 0.004 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr17_-_12992487 0.003 ENSMUST00000159551.1
ENSMUST00000160781.1
Wtap

Wilms' tumour 1-associating protein

chr15_-_89425856 0.002 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr1_+_74284930 0.002 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr14_+_54360826 0.002 ENSMUST00000000985.5
Oxa1l
oxidase assembly 1-like
chr11_+_116853752 0.001 ENSMUST00000021173.7
Mfsd11
major facilitator superfamily domain containing 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.3 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.3 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.1 0.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.3 GO:0015879 carnitine transport(GO:0015879)
0.0 0.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 0.1 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.0 0.1 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 0.2 GO:0048045 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)