Motif ID: Mef2d_Mef2a

Z-value: 1.134

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142536_881425720.411.4e-01Click!
Mef2amm10_v2_chr7_-_67372846_673728580.401.5e-01Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 3.323 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr1_-_64122256 2.971 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr11_+_111066154 2.693 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr13_-_113663670 2.489 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr1_-_64121389 2.326 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_-_172043466 2.259 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr10_+_69785507 2.251 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr13_+_5861489 2.221 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr5_+_24985840 2.140 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr14_-_66280949 1.954 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
 Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr19_-_34879452 1.679 ENSMUST00000036584.5
 Pank1
pantothenate kinase 1
chr10_+_90576872 1.538 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr4_+_62663620 1.431 ENSMUST00000126338.1
 Rgs3
regulator of G-protein signaling 3
chr7_+_91090728 1.399 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 1.392 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr6_-_136171722 1.368 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr8_+_76902277 1.344 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr1_-_64121456 1.323 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr13_-_102906046 1.271 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_+_69241832 1.265 ENSMUST00000063445.6
 Klhdc1
kelch domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0048813 dendrite morphogenesis(GO:0048813)
1.1 3.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 3.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 2.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.5 2.7 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.2 2.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.7 2.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.4 2.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 2.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 2.1 GO:0031958 corticosteroid receptor signaling pathway(GO:0031958)
0.7 2.0 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.1 1.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 1.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.5 1.4 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.0 1.4 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 1.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 1.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 2.5 GO:0030426 growth cone(GO:0030426)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 2.2 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.9 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.7 GO:0030118 clathrin coat(GO:0030118)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.1 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.0 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.9 GO:0090537 CERF complex(GO:0090537)
0.1 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 0.7 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 3.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 3.1 GO:0008017 microtubule binding(GO:0008017)
0.5 3.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.5 2.7 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 2.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.2 GO:0030275 LRR domain binding(GO:0030275)
0.0 1.8 GO:0042562 hormone binding(GO:0042562)
0.3 1.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 1.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.5 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 1.2 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 1.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)