Motif ID: Sox18_Sox12

Z-value: 0.796

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox18mm10_v2_chr2_-_181671622_1816716450.302.9e-01Click!
Sox12mm10_v2_chr2_-_152398046_152398076-0.078.1e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 1.526 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr4_-_136886187 1.071 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chrY_-_1286563 0.893 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr7_-_100514800 0.757 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr4_-_149126688 0.715 ENSMUST00000030815.2
 Cort
cortistatin
chr10_-_62792243 0.660 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr18_+_37355271 0.622 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chr4_+_139923349 0.609 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr9_-_32541589 0.586 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr1_-_140183404 0.578 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr7_+_100493795 0.545 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr7_+_127800604 0.519 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr2_+_176236860 0.510 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr17_+_21555046 0.499 ENSMUST00000079242.3
 Zfp52
zinc finger protein 52
chr15_+_6422240 0.463 ENSMUST00000163082.1
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr10_+_97482350 0.461 ENSMUST00000163448.2
 Dcn
decorin
chr11_+_24076529 0.451 ENSMUST00000148087.1
 Gm12063
predicted gene 12063
chr3_+_63295815 0.442 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr3_-_113577743 0.440 ENSMUST00000067980.5
 Amy1
amylase 1, salivary
chr11_-_109472611 0.430 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.9 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.8 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.5 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.4 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.3 GO:0050765 negative regulation of phagocytosis(GO:0050765)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.2 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.3 0.8 GO:0001851 complement component C3b binding(GO:0001851)
0.2 0.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)