Motif ID: Rfx2_Rfx7

Z-value: 1.246

Transcription factors associated with Rfx2_Rfx7:

Gene SymbolEntrez IDGene Name
Rfx2 ENSMUSG00000024206.8 Rfx2
Rfx7 ENSMUSG00000037674.9 Rfx7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx2mm10_v2_chr17_-_56830916_56831008-0.651.3e-02Click!
Rfx7mm10_v2_chr9_+_72532214_72532271-0.097.6e-01Click!


Activity profile for motif Rfx2_Rfx7.

activity profile for motif Rfx2_Rfx7


Sorted Z-values histogram for motif Rfx2_Rfx7

Sorted Z-values for motif Rfx2_Rfx7



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_128953303 3.550 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr2_-_118703963 2.665 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr9_+_49102720 2.418 ENSMUST00000070390.5
ENSMUST00000167095.1
 Tmprss5

transmembrane protease, serine 5 (spinesin)

chr11_-_7213897 2.244 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr7_-_119896285 1.616 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr11_+_103649498 1.588 ENSMUST00000057870.2
 Rprml
reprimo-like
chr11_+_119942763 1.580 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr5_-_116288944 1.547 ENSMUST00000086483.3
 Ccdc60
coiled-coil domain containing 60
chr12_-_83439910 1.401 ENSMUST00000177801.1
 Dpf3
D4, zinc and double PHD fingers, family 3
chr2_+_21205719 1.363 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
 Thnsl1




threonine synthase-like 1 (bacterial)




chr12_+_111166485 1.333 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3
chr7_-_73537621 1.297 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr2_-_101628930 1.279 ENSMUST00000099682.2
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr2_+_32775769 1.182 ENSMUST00000066352.5
 Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr7_+_100495987 1.165 ENSMUST00000133044.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr16_+_52031549 1.136 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chrX_+_95711641 1.116 ENSMUST00000150123.1
 Zc3h12b
zinc finger CCCH-type containing 12B
chr8_+_36993551 1.084 ENSMUST00000098825.3
 AI429214
expressed sequence AI429214
chr2_-_101628958 1.044 ENSMUST00000111231.3
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr8_+_94772009 1.022 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 2.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 2.2 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.2 1.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.6 GO:0010225 response to UV-C(GO:0010225)
0.1 1.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 1.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 1.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 1.4 GO:0098792 xenophagy(GO:0098792)
0.1 1.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 1.2 GO:0032543 mitochondrial translation(GO:0032543)
0.4 1.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 1.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 1.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 1.0 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 1.0 GO:0007032 endosome organization(GO:0007032)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.3 0.9 GO:0001830 trophectodermal cell fate commitment(GO:0001830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 2.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 2.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 1.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.9 GO:0034464 BBSome(GO:0034464)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.8 GO:0000235 astral microtubule(GO:0000235)
0.2 0.7 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 0.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0031996 thioesterase binding(GO:0031996)
0.1 2.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 2.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 1.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 1.7 GO:0046790 virion binding(GO:0046790)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.5 1.6 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.2 1.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.4 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.2 1.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.9 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)