Motif ID: Nkx2-5

Z-value: 0.950


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_88978958 5.708 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr3_+_52268337 4.184 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr8_-_46294592 2.964 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_10470490 2.691 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr6_+_30541582 1.670 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr1_+_172341197 1.601 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_54919961 1.412 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr4_+_62619515 1.247 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr12_+_74297474 1.242 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr4_-_4138432 1.241 ENSMUST00000070375.7
 Penk
preproenkephalin
chr12_+_91400990 1.189 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr18_-_15063560 1.176 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr15_-_54920115 1.149 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chrX_+_114474312 1.060 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr3_+_103739366 1.030 ENSMUST00000106852.1
 Gm10964
predicted gene 10964
chr12_+_103314944 0.994 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr11_-_78550777 0.883 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr1_-_66817536 0.871 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_101987004 0.861 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr1_-_163725123 0.818 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr1_-_86359455 0.817 ENSMUST00000027438.6
 Ncl
nucleolin
chr1_+_128103297 0.807 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1
chr3_-_33082004 0.804 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like
chr6_-_115853346 0.787 ENSMUST00000032469.6
 Mbd4
methyl-CpG binding domain protein 4
chr8_-_45382198 0.690 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr14_+_70530819 0.672 ENSMUST00000047331.6
 Lgi3
leucine-rich repeat LGI family, member 3
chr17_+_88440711 0.633 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr16_+_44139821 0.585 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr1_+_74713551 0.502 ENSMUST00000027356.5
 Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr14_+_80000292 0.499 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_127792467 0.497 ENSMUST00000135091.1
 1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr15_-_82224330 0.468 ENSMUST00000089161.2
ENSMUST00000109535.2
 Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chrX_-_75416533 0.450 ENSMUST00000033542.4
 Mtcp1
mature T cell proliferation 1
chr5_-_124327883 0.410 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr14_+_51893610 0.406 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr7_-_4844665 0.342 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chrX_-_111463043 0.335 ENSMUST00000065976.5
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr19_-_40271506 0.316 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)
chr4_-_140323302 0.311 ENSMUST00000063789.2
 Gm9867
predicted gene 9867
chr4_+_137594140 0.307 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
 Usp48



ubiquitin specific peptidase 48



chr5_-_124327812 0.306 ENSMUST00000184951.1
 Mphosph9
M-phase phosphoprotein 9
chr11_-_96977660 0.305 ENSMUST00000107626.1
ENSMUST00000107624.1
 Sp2

Sp2 transcription factor

chrX_-_75416562 0.304 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
 Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr18_-_31949571 0.303 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr7_+_18991245 0.303 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
 Mypop


Myb-related transcription factor, partner of profilin


chr10_-_127311740 0.302 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr4_+_148000722 0.302 ENSMUST00000103230.4
 Nppa
natriuretic peptide type A
chr17_+_35379608 0.299 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr18_-_79109391 0.271 ENSMUST00000025430.8
ENSMUST00000161465.2
 Setbp1

SET binding protein 1

chr2_+_120609383 0.256 ENSMUST00000124187.1
 Haus2
HAUS augmin-like complex, subunit 2
chr4_-_126968124 0.247 ENSMUST00000106108.2
 Zmym4
zinc finger, MYM-type 4
chr9_+_78051938 0.222 ENSMUST00000024104.7
 Gcm1
glial cells missing homolog 1 (Drosophila)
chrX_-_111463149 0.217 ENSMUST00000096348.3
ENSMUST00000113428.2
 Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr5_+_128601106 0.217 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chrX_-_111463103 0.212 ENSMUST00000137712.2
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr14_+_21500879 0.200 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chrX_+_13071500 0.199 ENSMUST00000089302.4
 Usp9x
ubiquitin specific peptidase 9, X chromosome
chr11_-_80080928 0.198 ENSMUST00000103233.3
ENSMUST00000061283.8
 Crlf3

cytokine receptor-like factor 3

chr4_-_45532470 0.193 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr2_+_174076296 0.182 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
 Stx16


syntaxin 16


chr15_-_99457712 0.177 ENSMUST00000161948.1
 Nckap5l
NCK-associated protein 5-like
chr2_+_52038005 0.167 ENSMUST00000065927.5
 Tnfaip6
tumor necrosis factor alpha induced protein 6
chr10_+_22645011 0.158 ENSMUST00000042261.4
 Slc2a12
solute carrier family 2 (facilitated glucose transporter), member 12
chr5_+_138085083 0.134 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
 Zkscan1


zinc finger with KRAB and SCAN domains 1


chr15_+_76351303 0.128 ENSMUST00000023212.8
ENSMUST00000160172.1
 Maf1

MAF1 homolog (S. cerevisiae)

chr7_+_100607660 0.122 ENSMUST00000098252.4
 Rab6a
RAB6A, member RAS oncogene family
chr2_+_127270208 0.116 ENSMUST00000110375.2
 Stard7
START domain containing 7
chr3_-_89160155 0.116 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr5_-_106624390 0.116 ENSMUST00000112694.1
 Zfp644
zinc finger protein 644
chr9_+_57940104 0.116 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr4_-_87806276 0.115 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_87806296 0.114 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr4_+_42714926 0.092 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr16_+_44943737 0.092 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr8_-_95113334 0.083 ENSMUST00000169353.1
 Kifc3
kinesin family member C3
chr15_-_79328201 0.077 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
 Pla2g6



phospholipase A2, group VI



chrX_-_7898950 0.074 ENSMUST00000115655.1
ENSMUST00000156741.1
 Pqbp1

polyglutamine binding protein 1

chr12_+_4082596 0.067 ENSMUST00000049584.5
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr8_+_113643206 0.065 ENSMUST00000034219.4
ENSMUST00000095173.1
 Syce1l

synaptonemal complex central element protein 1 like

chr2_+_32288317 0.064 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
 Golga2




golgi autoantigen, golgin subfamily a, 2




chr12_+_37880700 0.061 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr7_+_29071597 0.055 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr6_+_115853470 0.050 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
 Ift122


intraflagellar transport 122


chr6_-_83572429 0.049 ENSMUST00000068054.7
 Stambp
STAM binding protein
chr16_-_44139630 0.041 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr1_-_181842334 0.022 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr9_+_98422961 0.001 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 1.6 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.5 4.2 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.4 2.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 1.2 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.2 0.8 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.2 3.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 0.5 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.8 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 1.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 0.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.2 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.0 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.0 0.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.8 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0032280 symmetric synapse(GO:0032280)
0.2 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.8 GO:0001651 dense fibrillar component(GO:0001651)
0.1 1.5 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.0 5.7 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.5 1.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 4.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 0.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 0.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 5.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0080084 RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:0045296 cadherin binding(GO:0045296)