Motif ID: Nkx2-5

Z-value: 0.950


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 5.708 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr3_+_52268337 4.184 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr8_-_46294592 2.964 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_10470490 2.691 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr6_+_30541582 1.670 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr1_+_172341197 1.601 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_54919961 1.412 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr4_+_62619515 1.247 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr12_+_74297474 1.242 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr4_-_4138432 1.241 ENSMUST00000070375.7
 Penk
preproenkephalin
chr12_+_91400990 1.189 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr18_-_15063560 1.176 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr15_-_54920115 1.149 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chrX_+_114474312 1.060 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr3_+_103739366 1.030 ENSMUST00000106852.1
 Gm10964
predicted gene 10964
chr12_+_103314944 0.994 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr11_-_78550777 0.883 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr1_-_66817536 0.871 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_101987004 0.861 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr1_-_163725123 0.818 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 4.2 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 3.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 2.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.5 1.6 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 1.2 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 1.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.2 0.8 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.8 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.8 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 0.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 0.5 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.0 0.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0005901 caveola(GO:0005901)
0.1 1.5 GO:0097449 astrocyte projection(GO:0097449)
0.3 1.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.8 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0008565 protein transporter activity(GO:0008565)
0.3 4.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.6 2.6 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 1.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.2 0.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.8 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.5 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)