Motif ID: Tcf3

Z-value: 1.111


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80421847_80421876-0.322.6e-01Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_171234290 2.248 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr12_-_34528844 1.911 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr2_-_122611238 1.830 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr16_+_91269759 1.742 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_+_122289297 1.712 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr6_+_104492790 1.706 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
 Cntn6


contactin 6


chr15_-_71727815 1.368 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr19_+_7056731 1.325 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chrX_+_169879596 1.291 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr3_-_144205165 1.199 ENSMUST00000120539.1
 Lmo4
LIM domain only 4
chr6_+_29694204 1.147 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr14_-_66213552 1.088 ENSMUST00000178730.1
 Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr11_+_102836296 1.035 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr5_+_17574726 1.026 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr2_+_103969528 1.020 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr10_+_123264076 0.978 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr13_-_92131494 0.975 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr9_-_40346290 0.970 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr7_+_35119285 0.969 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr13_+_37345338 0.930 ENSMUST00000021860.5
 Ly86
lymphocyte antigen 86

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.8 2.4 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.4 2.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 2.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 1.9 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.6 1.8 GO:0006601 creatine biosynthetic process(GO:0006601)
0.4 1.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.3 1.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.5 1.5 GO:0021649 vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.1 1.5 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 1.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 1.1 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 1.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 1.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 1.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 0.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 0.9 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 1.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.0 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0005605 basal lamina(GO:0005605)
0.3 0.8 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 0.8 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.7 2.2 GO:0019863 IgE binding(GO:0019863)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.7 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 1.6 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.5 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 1.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 1.0 GO:0050436 microfibril binding(GO:0050436)
0.1 1.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)