Motif ID: Emx1_Emx2

Z-value: 0.456

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx2mm10_v2_chr19_+_59458372_59458450-0.283.3e-01Click!
Emx1mm10_v2_chr6_+_85187438_851875100.195.0e-01Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_144209448 0.985 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr6_-_144209471 0.949 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 0.940 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_-_82505707 0.712 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr9_+_34904913 0.702 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr8_-_21906412 0.608 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr3_+_127633134 0.475 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr3_+_121953213 0.468 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr1_-_40085823 0.465 ENSMUST00000181756.1
 Gm16894
predicted gene, 16894
chr17_-_48432723 0.453 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr13_-_58354862 0.447 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr14_+_26259109 0.439 ENSMUST00000174494.1
 Duxbl3
double homeobox B-like 3
chr4_-_82505749 0.432 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505274 0.421 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr7_+_126781483 0.419 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr7_-_42706369 0.354 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chr10_+_90071095 0.354 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_102589687 0.328 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_-_96519067 0.313 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr17_+_45734506 0.296 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 1.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 0.7 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.1 0.4 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0080111 DNA demethylation(GO:0080111)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 0.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0051542 elastin biosynthetic process(GO:0051542)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.0 0.1 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.3 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.1 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.0 0.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)