Motif ID: Tcf7l1

Z-value: 1.247


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.441.2e-01Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_108920800 2.704 ENSMUST00000140821.1
 Axin2
axin2
chr4_+_85205120 2.412 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr4_+_85205417 2.299 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr6_+_51432678 2.283 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr6_+_51432663 2.205 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr6_+_17065129 2.177 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
 Tes


testis derived transcript


chr4_-_142239356 2.111 ENSMUST00000036476.3
 Kazn
kazrin, periplakin interacting protein
chr2_+_153031852 2.096 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr1_-_183147461 2.014 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr5_+_65131184 1.964 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr2_+_152081529 1.893 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr7_+_100493795 1.811 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr10_+_80150448 1.598 ENSMUST00000153477.1
 Midn
midnolin
chr16_+_4968936 1.472 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr11_+_108921648 1.470 ENSMUST00000144511.1
 Axin2
axin2
chr9_-_103761820 1.461 ENSMUST00000049452.8
 Tmem108
transmembrane protein 108
chr7_-_83884289 1.436 ENSMUST00000094216.3
 Mesdc1
mesoderm development candidate 1
chr3_+_131110350 1.326 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr2_+_173022360 1.285 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr9_+_102717668 1.281 ENSMUST00000035121.7
 Amotl2
angiomotin-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.3 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 4.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.3 2.4 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 2.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.2 2.1 GO:0031424 keratinization(GO:0031424)
0.2 2.0 GO:0060539 diaphragm development(GO:0060539)
0.0 2.0 GO:0009749 response to glucose(GO:0009749)
0.0 1.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 1.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.5 GO:0007440 foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.4 1.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 1.3 GO:0031648 protein destabilization(GO:0031648)
0.2 1.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 1.2 GO:0035329 hippo signaling(GO:0035329)
0.2 1.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 1.1 GO:0042711 maternal behavior(GO:0042711)
0.1 1.0 GO:0097421 liver regeneration(GO:0097421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 3.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)
0.5 2.1 GO:0001533 cornified envelope(GO:0001533)
0.1 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 1.1 GO:0005638 lamin filament(GO:0005638)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 0.9 GO:1990032 parallel fiber(GO:1990032)
0.2 0.9 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 0.8 GO:0008623 CHRAC(GO:0008623)
0.1 0.8 GO:0016460 myosin II complex(GO:0016460)
0.1 0.7 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0015197 peptide transporter activity(GO:0015197)
0.1 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 1.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 1.1 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 0.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)