Motif ID: Esrrb_Esrra

Z-value: 1.018

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921804_69218340.303.0e-01Click!
Esrrbmm10_v2_chr12_+_86421782_86421883-0.117.0e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_33276334 2.456 ENSMUST00000183831.1
 Gm12117
predicted gene 12117
chrX_-_141874870 1.494 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr1_-_167393826 1.329 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr2_-_73911323 1.253 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr19_-_47090610 1.168 ENSMUST00000096014.3
 Usmg5
upregulated during skeletal muscle growth 5
chr11_+_121702591 1.166 ENSMUST00000125580.1
 Metrnl
meteorin, glial cell differentiation regulator-like
chr8_-_70523085 1.081 ENSMUST00000137610.1
ENSMUST00000121623.1
ENSMUST00000093456.5
ENSMUST00000118850.1
 Kxd1



KxDL motif containing 1



chr11_+_120484613 0.960 ENSMUST00000043627.7
 Mrpl12
mitochondrial ribosomal protein L12
chr15_+_84669565 0.880 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr2_+_121357714 0.863 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr7_+_46847128 0.854 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr11_+_6415443 0.821 ENSMUST00000132846.1
 Ppia
peptidylprolyl isomerase A
chr2_+_121358591 0.818 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr1_+_63176818 0.795 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr19_-_3912711 0.791 ENSMUST00000075092.6
 Ndufs8
NADH dehydrogenase (ubiquinone) Fe-S protein 8
chr8_+_84970068 0.782 ENSMUST00000164807.1
 Prdx2
peroxiredoxin 2
chr18_+_6332587 0.778 ENSMUST00000097682.2
 Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr10_+_128083273 0.774 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr4_+_99929414 0.772 ENSMUST00000058351.9
 Pgm2
phosphoglucomutase 2
chr9_-_44920698 0.767 ENSMUST00000043675.7
 Atp5l
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 1.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.8 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
0.2 1.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 1.5 GO:0006006 glucose metabolic process(GO:0006006)
0.1 1.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 1.3 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 1.2 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 1.2 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.1 GO:0016575 histone deacetylation(GO:0016575)
0.3 1.0 GO:0019043 establishment of viral latency(GO:0019043)
0.3 1.0 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.1 1.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 0.9 GO:0019249 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0 0.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.2 0.8 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.8 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.2 4.1 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.0 3.6 GO:0043209 myelin sheath(GO:0043209)
0.1 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 1.9 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.2 1.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 1.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 0.9 GO:0005861 troponin complex(GO:0005861)
0.1 0.9 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 2.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.1 1.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.8 GO:0015266 protein channel activity(GO:0015266)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.6 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 1.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 1.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 1.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 0.9 GO:0030172 troponin C binding(GO:0030172)
0.2 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.8 GO:0016018 cyclosporin A binding(GO:0016018)