Motif ID: Tcf21_Msc

Z-value: 0.687

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_57104693 1.177 ENSMUST00000055698.7
 Gjb2
gap junction protein, beta 2
chr8_+_94172618 1.009 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr3_+_90537242 0.975 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr3_+_90537306 0.962 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr4_+_144893077 0.879 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_105973711 0.785 ENSMUST00000000573.2
 Ovgp1
oviductal glycoprotein 1
chr1_-_14310198 0.777 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr7_+_25152456 0.772 ENSMUST00000098678.1
 D930028M14Rik
RIKEN cDNA D930028M14 gene
chr18_+_60293372 0.737 ENSMUST00000171297.1
 F830016B08Rik
RIKEN cDNA F830016B08 gene
chr16_+_91269759 0.734 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chrM_+_7005 0.714 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr5_+_8660059 0.682 ENSMUST00000047753.4
 Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr11_-_23519181 0.679 ENSMUST00000020527.5
 1700093K21Rik
RIKEN cDNA 1700093K21 gene
chr9_+_58134535 0.668 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
 Stra6



stimulated by retinoic acid gene 6



chr11_-_55419898 0.650 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr16_+_20591156 0.644 ENSMUST00000159780.1
 Vwa5b2
von Willebrand factor A domain containing 5B2
chr12_-_72664759 0.641 ENSMUST00000021512.9
 Dhrs7
dehydrogenase/reductase (SDR family) member 7
chr8_-_122432924 0.637 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr1_-_162866502 0.632 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr4_+_144892813 0.627 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.9 GO:0051592 response to calcium ion(GO:0051592)
0.1 1.2 GO:0016264 gap junction assembly(GO:0016264)
0.1 1.0 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 0.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.8 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.8 GO:0009404 toxin metabolic process(GO:0009404)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.7 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 0.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.7 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.7 GO:0048663 neuron fate commitment(GO:0048663)
0.2 0.6 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.2 0.6 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.5 GO:1903887 motile primary cilium assembly(GO:1903887)
0.1 0.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.5 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.0 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.7 GO:0030312 external encapsulating structure(GO:0030312)
0.2 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.6 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.4 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0098536 deuterosome(GO:0098536)
0.1 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.4 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.3 GO:0071438 integrin alpha3-beta1 complex(GO:0034667) invadopodium membrane(GO:0071438)
0.1 0.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.2 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 0.8 GO:0004568 chitinase activity(GO:0004568)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.7 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.7 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0051183 vitamin transporter activity(GO:0051183)
0.2 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0045703 pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.1 0.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)