Motif ID: Pax4

Z-value: 0.667


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_73097017 1.697 ENSMUST00000114524.2
ENSMUST00000074619.5
 Xlr3a

X-linked lymphocyte-regulated 3A

chrX_+_73192222 1.627 ENSMUST00000101486.4
 Xlr3b
X-linked lymphocyte-regulated 3B
chr10_+_119992916 1.051 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr10_-_64090265 0.810 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090241 0.766 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_65238625 0.681 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
 Cobll1


Cobl-like 1


chr10_-_62792243 0.636 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr13_+_38204928 0.569 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr9_+_32696005 0.565 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
 Ets1


E26 avian leukemia oncogene 1, 5' domain


chr3_+_20057802 0.550 ENSMUST00000002502.5
 Hltf
helicase-like transcription factor
chr12_+_71048338 0.528 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_+_107271827 0.511 ENSMUST00000020057.8
ENSMUST00000105280.3
 Lin7a

lin-7 homolog A (C. elegans)

chr4_+_147132038 0.506 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr11_+_43587040 0.504 ENSMUST00000056256.2
 4933415A04Rik
RIKEN cDNA 4933415A04 gene
chrX_-_9662950 0.498 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr19_-_10482874 0.495 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr11_+_78499087 0.412 ENSMUST00000017488.4
 Vtn
vitronectin
chr16_-_45844303 0.401 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844228 0.401 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr4_+_146610961 0.357 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr9_-_101198999 0.324 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr17_+_17402672 0.286 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chrM_+_3906 0.279 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr2_+_22895482 0.279 ENSMUST00000053729.7
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr7_+_58658181 0.277 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr15_-_50889691 0.274 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chrX_-_75875101 0.265 ENSMUST00000114059.3
 Pls3
plastin 3 (T-isoform)
chr12_-_80112998 0.264 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr14_-_12823031 0.257 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
 Cadps



Ca2+-dependent secretion activator



chr4_-_88033328 0.249 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr5_-_121502980 0.230 ENSMUST00000079368.3
 Adam1b
a disintegrin and metallopeptidase domain 1b
chr1_-_88008520 0.229 ENSMUST00000040783.4
 Usp40
ubiquitin specific peptidase 40
chr2_+_22895583 0.227 ENSMUST00000152170.1
 Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr13_+_21717626 0.226 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr9_-_58159201 0.224 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr4_+_136357423 0.210 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr16_+_15637844 0.210 ENSMUST00000023352.8
 Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr13_-_55528511 0.209 ENSMUST00000047877.4
 Dok3
docking protein 3
chr1_-_156034800 0.208 ENSMUST00000169241.1
 Tor1aip1
torsin A interacting protein 1
chr9_-_103222063 0.200 ENSMUST00000170904.1
 Trf
transferrin
chrX_+_143518576 0.182 ENSMUST00000033640.7
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr1_-_74935549 0.159 ENSMUST00000094844.3
 Ccdc108
coiled-coil domain containing 108
chr13_-_101768154 0.149 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_-_125506385 0.138 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr15_-_97055942 0.128 ENSMUST00000023101.3
 Slc38a4
solute carrier family 38, member 4
chr13_+_109632760 0.126 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr2_-_105904484 0.122 ENSMUST00000122965.1
 Elp4
elongation protein 4 homolog (S. cerevisiae)
chr13_-_23430826 0.117 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr16_-_14291355 0.106 ENSMUST00000090287.3
 Myh11
myosin, heavy polypeptide 11, smooth muscle
chr19_+_53140430 0.105 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr4_+_150087365 0.098 ENSMUST00000094451.3
 Gpr157
G protein-coupled receptor 157
chr5_-_116288944 0.091 ENSMUST00000086483.3
 Ccdc60
coiled-coil domain containing 60
chr12_-_98577940 0.087 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr14_-_59395381 0.084 ENSMUST00000166912.2
 Phf11c
PHD finger protein 11C
chr2_-_114654943 0.083 ENSMUST00000028640.7
ENSMUST00000102542.3
 Dph6

diphthamine biosynthesis 6

chr19_-_32712287 0.079 ENSMUST00000070210.4
 Atad1
ATPase family, AAA domain containing 1
chr15_-_89149557 0.071 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr17_+_26941420 0.052 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr5_-_116591811 0.051 ENSMUST00000076124.5
 Srrm4
serine/arginine repetitive matrix 4
chrX_-_8206475 0.047 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
 Porcn



porcupine homolog (Drosophila)



chr2_-_114654861 0.031 ENSMUST00000055144.7
 Dph6
diphthamine biosynthesis 6
chr4_-_58987095 0.027 ENSMUST00000030069.6
 Ptgr1
prostaglandin reductase 1
chr12_-_90738438 0.022 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr2_+_122234749 0.022 ENSMUST00000110551.3
 Sord
sorbitol dehydrogenase
chr9_-_48835932 0.021 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr18_+_53862087 0.007 ENSMUST00000069597.6
 Csnk1g3
casein kinase 1, gamma 3
chr13_+_23738804 0.003 ENSMUST00000040914.1
 Hist1h1c
histone cluster 1, H1c
chr4_+_150281573 0.003 ENSMUST00000105682.2
 Rere
arginine glutamic acid dipeptide (RE) repeats

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 0.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 1.6 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 0.5 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.4 GO:0097421 liver regeneration(GO:0097421)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)
0.0 0.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 3.3 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.3 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0006301 postreplication repair(GO:0006301)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.3 GO:0045956 synaptic vesicle priming(GO:0016082) positive regulation of calcium ion-dependent exocytosis(GO:0045956)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.8 GO:0045180 basal cortex(GO:0045180)
0.1 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0001527 microfibril(GO:0001527)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)