Motif ID: Zic4

Z-value: 0.696


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91378636_913786460.391.7e-01Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 195 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 2.601 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr11_-_102946688 1.718 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr6_-_35308110 1.600 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr2_+_85136355 1.523 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr4_-_64046925 1.474 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_+_91179822 1.443 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr11_-_101171302 1.255 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr4_-_72200833 1.220 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chrY_+_897782 1.216 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr11_+_5861886 1.160 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr2_+_180598219 1.152 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr3_-_107986408 1.078 ENSMUST00000012348.2
 Gstm2
glutathione S-transferase, mu 2
chr15_-_97831460 1.026 ENSMUST00000079838.7
ENSMUST00000118294.1
 Hdac7

histone deacetylase 7

chr14_-_64455903 0.992 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr11_-_6475992 0.962 ENSMUST00000179343.1
 Purb
purine rich element binding protein B
chr18_+_52767994 0.957 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
 Sncaip


synuclein, alpha interacting protein (synphilin)


chr6_+_29433248 0.929 ENSMUST00000101617.2
ENSMUST00000065090.5
 Flnc

filamin C, gamma

chr2_+_119325784 0.894 ENSMUST00000102517.3
 Dll4
delta-like 4 (Drosophila)
chr17_-_71310952 0.867 ENSMUST00000024849.9
 Emilin2
elastin microfibril interfacer 2
chr19_-_57008187 0.866 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 1.7 GO:0061743 motor learning(GO:0061743)
0.2 1.7 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.5 1.6 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.3 1.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 1.6 GO:0048747 muscle fiber development(GO:0048747)
0.4 1.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 1.5 GO:0007369 gastrulation(GO:0007369)
0.3 1.4 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.2 1.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 1.2 GO:2000811 negative regulation of anoikis(GO:2000811)
0.2 1.0 GO:0030091 protein repair(GO:0030091)
0.1 1.0 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 1.0 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 1.0 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.3 0.9 GO:0072554 blood vessel lumenization(GO:0072554)
0.3 0.9 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.2 0.9 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.9 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.3 0.8 GO:0035106 operant conditioning(GO:0035106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.7 GO:0044301 climbing fiber(GO:0044301)
0.0 1.6 GO:0016528 sarcoplasm(GO:0016528)
0.1 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 0.8 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.6 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.4 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.3 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 0.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 2.3 GO:0045545 syndecan binding(GO:0045545)
0.1 1.7 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 1.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.6 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.4 1.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 1.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.9 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)