Motif ID: Sox6_Sox9

Z-value: 1.534

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_1127822480.752.2e-03Click!
Sox6mm10_v2_chr7_-_116038734_1160387500.136.6e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_12749193 4.434 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr12_+_119945957 4.113 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chr15_+_6386598 3.851 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr1_-_72874877 3.734 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr2_+_180598219 3.521 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr2_+_146221921 3.379 ENSMUST00000089257.4
 Insm1
insulinoma-associated 1
chr3_+_34649987 3.373 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr12_-_34528844 3.356 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr9_-_79718631 3.297 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr1_+_135729147 3.252 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr6_+_17463749 3.240 ENSMUST00000115443.1
 Met
met proto-oncogene
chr10_-_62792243 2.957 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr9_-_79718518 2.948 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr18_+_37484955 2.867 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr6_+_86404219 2.812 ENSMUST00000095754.3
ENSMUST00000095753.2
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr13_-_97747373 2.811 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr15_-_91049823 2.721 ENSMUST00000088614.5
ENSMUST00000100304.4
ENSMUST00000067205.8
ENSMUST00000109288.2
ENSMUST00000109287.2
 Kif21a




kinesin family member 21A




chr11_-_106715251 2.623 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr18_-_15063560 2.614 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr9_-_79718720 2.598 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.9 5.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 5.0 GO:0007605 sensory perception of sound(GO:0007605)
0.8 3.9 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.5 3.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 3.7 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.8 3.4 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.5 3.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 3.3 GO:0070527 platelet aggregation(GO:0070527)
1.1 3.2 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.1 3.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.3 2.9 GO:0051923 sulfation(GO:0051923)
0.7 2.6 GO:0050904 diapedesis(GO:0050904)
0.2 2.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.8 2.5 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.6 2.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 2.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 2.5 GO:0021546 rhombomere development(GO:0021546)
0.1 2.5 GO:0001573 ganglioside metabolic process(GO:0001573)
0.3 2.4 GO:0061042 vascular wound healing(GO:0061042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.8 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.8 7.4 GO:0097165 nuclear stress granule(GO:0097165)
0.1 4.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
1.0 3.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.9 3.7 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.9 3.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.7 3.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.4 3.2 GO:0030478 actin cap(GO:0030478)
0.1 3.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.5 2.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 2.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 2.1 GO:0001739 sex chromatin(GO:0001739)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.4 2.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.6 1.9 GO:0000811 GINS complex(GO:0000811)
0.1 1.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 6.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.4 5.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 4.0 GO:0030332 cyclin binding(GO:0030332)
0.4 3.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 3.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 3.4 GO:0035198 miRNA binding(GO:0035198)
0.1 3.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.8 3.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.0 2.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 2.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.9 GO:0031402 sodium ion binding(GO:0031402)
0.3 2.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.8 2.5 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 2.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 1.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)