Motif ID: Hoxb1

Z-value: 1.001


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_123982799 5.284 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr1_+_153665274 5.023 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr19_-_41743665 3.515 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr1_+_127306706 3.125 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr7_+_73391160 2.413 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr3_+_127633134 2.259 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chrX_+_143518671 2.130 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr2_+_65845833 1.808 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr10_+_4266323 1.779 ENSMUST00000045730.5
 Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr1_-_119053339 1.748 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr8_-_8639363 1.678 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr8_-_87959560 1.628 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr18_-_56562187 1.270 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562215 1.243 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr4_+_103114712 1.090 ENSMUST00000143417.1
 Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr1_-_119053619 1.074 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr1_-_157412576 1.055 ENSMUST00000078308.6
ENSMUST00000139470.1
 Rasal2

RAS protein activator like 2

chr15_+_74516196 1.031 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr4_-_35845204 0.944 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr2_+_124610573 0.926 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr4_-_103114238 0.921 ENSMUST00000036451.8
ENSMUST00000036557.8
 Wdr78

WD repeat domain 78

chr2_+_124610278 0.915 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr12_-_15816762 0.807 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr8_+_84901928 0.805 ENSMUST00000067060.7
 Klf1
Kruppel-like factor 1 (erythroid)
chr3_-_58525867 0.731 ENSMUST00000029385.7
 Serp1
stress-associated endoplasmic reticulum protein 1
chr2_+_65845767 0.713 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr3_+_58526303 0.710 ENSMUST00000138848.1
 Eif2a
eukaryotic translation initiation factor 2A
chr11_+_85353156 0.706 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr18_-_56562261 0.692 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr4_-_103114555 0.686 ENSMUST00000106868.3
 Wdr78
WD repeat domain 78
chr7_+_48789003 0.683 ENSMUST00000118927.1
ENSMUST00000125280.1
 Zdhhc13

zinc finger, DHHC domain containing 13

chr17_+_26941420 0.677 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr11_+_97415527 0.604 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_40755201 0.595 ENSMUST00000020576.7
 Ccng1
cyclin G1
chr2_+_156475844 0.529 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr5_+_139543889 0.519 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_43669610 0.516 ENSMUST00000107866.1
 Tmem8b
transmembrane protein 8B
chr2_+_156475803 0.512 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr12_-_27160311 0.509 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr3_-_88762244 0.493 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr10_-_63421739 0.453 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr2_+_119972699 0.433 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr2_-_153529941 0.400 ENSMUST00000035346.7
 8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr14_+_70555900 0.399 ENSMUST00000163060.1
 Hr
hairless
chr11_+_75486813 0.364 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
 Prpf8


pre-mRNA processing factor 8


chr8_-_117673682 0.363 ENSMUST00000173522.1
ENSMUST00000174450.1
 Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr2_+_147012996 0.362 ENSMUST00000028921.5
 Xrn2
5'-3' exoribonuclease 2
chr5_+_37735519 0.331 ENSMUST00000073554.3
 Cytl1
cytokine-like 1
chr3_+_58525821 0.330 ENSMUST00000029387.8
 Eif2a
eukaryotic translation initiation factor 2A
chr16_-_97962581 0.328 ENSMUST00000113734.2
ENSMUST00000052089.7
ENSMUST00000063605.7
 Zbtb21


zinc finger and BTB domain containing 21


chr15_+_89253035 0.318 ENSMUST00000088788.3
 Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr5_+_136967859 0.305 ENSMUST00000001790.5
 Cldn15
claudin 15
chr10_+_127677064 0.265 ENSMUST00000118612.1
ENSMUST00000048099.4
 Tmem194

transmembrane protein 194

chr9_-_108083330 0.264 ENSMUST00000159372.1
ENSMUST00000160249.1
 Rnf123

ring finger protein 123

chr7_-_78577771 0.244 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr17_+_34647128 0.237 ENSMUST00000015605.8
ENSMUST00000182587.1
 Atf6b

activating transcription factor 6 beta

chr5_+_19907774 0.219 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_-_63662910 0.214 ENSMUST00000184252.1
 Gm11214
predicted gene 11214
chr17_+_29490812 0.200 ENSMUST00000024811.6
 Pim1
proviral integration site 1
chr17_+_34647187 0.193 ENSMUST00000173984.1
 Atf6b
activating transcription factor 6 beta
chr15_-_95528702 0.173 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr4_-_91399984 0.154 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr11_-_83298873 0.154 ENSMUST00000175741.1
ENSMUST00000176518.1
 Pex12

peroxisomal biogenesis factor 12

chr14_-_69284982 0.139 ENSMUST00000183882.1
ENSMUST00000037064.4
 Slc25a37

solute carrier family 25, member 37

chr8_+_25808474 0.136 ENSMUST00000033979.4
 Star
steroidogenic acute regulatory protein
chr2_+_84840612 0.115 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr6_+_125145235 0.105 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
 Iffo1



intermediate filament family orphan 1



chr10_-_88605017 0.096 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr16_-_56024628 0.078 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr14_-_69503220 0.074 ENSMUST00000180059.2
 Gm21464
predicted gene, 21464
chr5_+_119834663 0.055 ENSMUST00000018407.6
 Tbx5
T-box 5
chr10_+_81628540 0.041 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chr1_+_39535747 0.020 ENSMUST00000003219.8
 Cnot11
CCR4-NOT transcription complex, subunit 11
chrX_-_8132770 0.013 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
 Wdr13



WD repeat domain 13




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0060032 notochord regression(GO:0060032)
0.5 3.5 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.4 5.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.3 1.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.2 2.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.2 1.7 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 1.0 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 0.5 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.1 0.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 2.1 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 0.8 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.1 1.8 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 0.8 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 3.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 2.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 1.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.4 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 2.3 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.1 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 GO:0097542 ciliary tip(GO:0097542)
0.2 1.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 5.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.6 3.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.4 3.5 GO:0048495 Roundabout binding(GO:0048495)
0.2 0.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 2.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.2 5.3 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 0.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 0.4 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 5.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 2.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)