Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.620

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arxmm10_v2_chrX_+_93286499_93286522-0.332.4e-01Click!
Otpmm10_v2_chr13_+_94875600_948756110.234.3e-01Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_102906046 2.363 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621805 2.011 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_102905740 1.532 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621669 1.374 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr14_+_69347587 1.373 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr8_-_21906412 1.270 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr6_+_34029421 1.196 ENSMUST00000070189.3
ENSMUST00000101564.2
 Lrguk

leucine-rich repeats and guanylate kinase domain containing

chr4_-_14621494 1.062 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr16_+_11406618 1.025 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr17_-_32822200 0.881 ENSMUST00000179695.1
 Zfp799
zinc finger protein 799
chr14_-_88471396 0.824 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr10_+_37139558 0.817 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_+_65620829 0.811 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr7_+_39588931 0.677 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr4_+_103143052 0.626 ENSMUST00000106855.1
 Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr5_-_62765618 0.596 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_45103747 0.593 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr2_-_150255591 0.579 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr6_+_124304646 0.557 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr17_-_78684262 0.539 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.4 GO:0019532 oxalate transport(GO:0019532)
0.0 3.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.5 1.4 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.8 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.6 GO:0006953 acute-phase response(GO:0006953)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.4 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.1 0.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 0.4 GO:0051923 sulfation(GO:0051923)
0.0 0.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0019085 early viral transcription(GO:0019085)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.1 0.3 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.3 GO:0048630 skeletal muscle tissue growth(GO:0048630)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 1.2 GO:0002177 manchette(GO:0002177)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0043205 fibril(GO:0043205)
0.0 0.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.1 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 3.9 GO:0000287 magnesium ion binding(GO:0000287)
0.2 1.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.3 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.1 0.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.3 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.3 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.3 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)