Motif ID: Elf1_Elf2_Etv2_Elf4

Z-value: 2.116

Transcription factors associated with Elf1_Elf2_Etv2_Elf4:

Gene SymbolEntrez IDGene Name
Elf1 ENSMUSG00000036461.9 Elf1
Elf2 ENSMUSG00000037174.12 Elf2
Elf4 ENSMUSG00000031103.6 Elf4
Etv2 ENSMUSG00000006311.8 Etv2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf2mm10_v2_chr3_-_51340628_51340681-0.582.9e-02Click!
Elf1mm10_v2_chr14_+_79481164_79481194-0.421.3e-01Click!
Elf4mm10_v2_chrX_-_48454152_484541930.293.1e-01Click!


Activity profile for motif Elf1_Elf2_Etv2_Elf4.

activity profile for motif Elf1_Elf2_Etv2_Elf4


Sorted Z-values histogram for motif Elf1_Elf2_Etv2_Elf4

Sorted Z-values for motif Elf1_Elf2_Etv2_Elf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf1_Elf2_Etv2_Elf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_98358368 2.270 ENSMUST00000018311.4
 Stard3
START domain containing 3
chr2_+_156144203 2.200 ENSMUST00000109597.3
ENSMUST00000109598.3
ENSMUST00000119950.1
 Romo1


reactive oxygen species modulator 1


chr1_-_180330550 2.153 ENSMUST00000050581.3
 Gm5069
predicted pseudogene 5069
chr12_+_76533540 2.099 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr10_-_95324072 1.937 ENSMUST00000053594.5
 Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr4_-_124850670 1.906 ENSMUST00000163946.1
ENSMUST00000106190.3
 1110065P20Rik

RIKEN cDNA 1110065P20 gene

chr19_+_8920358 1.782 ENSMUST00000096243.5
 B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr18_+_60774675 1.782 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr3_-_130730375 1.778 ENSMUST00000079085.6
 Rpl34
ribosomal protein L34
chr18_+_60774510 1.718 ENSMUST00000025511.3
 Rps14
ribosomal protein S14
chr9_+_106429399 1.672 ENSMUST00000150576.1
 Rpl29
ribosomal protein L29
chr9_+_106429537 1.618 ENSMUST00000059802.6
 Rpl29
ribosomal protein L29
chr6_-_23248264 1.605 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_129129700 1.604 ENSMUST00000035481.4
 Chchd5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr11_+_70647258 1.579 ENSMUST00000037534.7
 Rnf167
ring finger protein 167
chr9_+_45055166 1.571 ENSMUST00000114664.1
ENSMUST00000093856.3
 Mpzl3

myelin protein zero-like 3

chr11_+_102285161 1.559 ENSMUST00000156326.1
 Tmub2
transmembrane and ubiquitin-like domain containing 2
chr1_-_92641942 1.547 ENSMUST00000097642.3
 Myeov2
myeloma overexpressed 2
chr17_+_35135174 1.504 ENSMUST00000166426.2
ENSMUST00000025250.7
 Bag6

BCL2-associated athanogene 6

chr7_-_6155939 1.504 ENSMUST00000094870.1
 Zfp787
zinc finger protein 787

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 918 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.6 GO:0006412 translation(GO:0006412)
0.6 13.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 9.7 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 7.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 6.2 GO:0009060 aerobic respiration(GO:0009060)
0.1 6.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 5.7 GO:0006413 translational initiation(GO:0006413)
0.6 4.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 4.5 GO:0006284 base-excision repair(GO:0006284)
0.2 4.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 4.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 3.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 3.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.6 3.3 GO:0001302 replicative cell aging(GO:0001302)
0.2 3.3 GO:0051451 myoblast migration(GO:0051451)
0.2 3.3 GO:0045116 protein neddylation(GO:0045116)
0.2 3.2 GO:0010388 cullin deneddylation(GO:0010388)
0.4 3.0 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.2 3.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.5 2.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 333 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 29.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 23.5 GO:0005739 mitochondrion(GO:0005739)
0.1 22.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 21.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 19.5 GO:1903561 extracellular vesicle(GO:1903561)
0.2 12.1 GO:0070469 respiratory chain(GO:0070469)
0.0 6.9 GO:0005925 focal adhesion(GO:0005925)
0.2 6.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.5 5.9 GO:0005687 U4 snRNP(GO:0005687)
0.2 4.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.7 4.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 4.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 4.1 GO:0005642 annulate lamellae(GO:0005642)
0.1 4.1 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.4 3.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 3.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 3.6 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 3.1 GO:0001891 phagocytic cup(GO:0001891)
0.4 3.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 571 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 52.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 8.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 7.0 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.5 6.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 5.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 5.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.6 5.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.3 4.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 4.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 4.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 3.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 3.3 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 3.1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0 3.0 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.2 2.9 GO:0031386 protein tag(GO:0031386)
0.4 2.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.3 2.7 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 2.7 GO:0070513 death domain binding(GO:0070513)