Motif ID: Pax6

Z-value: 0.952


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105675478_105675527-0.651.2e-02Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 9.405 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_57118897 2.138 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57118981 1.931 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr2_-_162661075 1.330 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr8_-_57962564 1.309 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr17_-_51831884 0.842 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr5_-_142906702 0.833 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr11_-_95587691 0.808 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr5_+_90903864 0.725 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr18_+_37447641 0.722 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr2_-_75981967 0.709 ENSMUST00000099994.3
 Ttc30a1
tetratricopeptide repeat domain 30A1
chr3_+_65109343 0.651 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr17_-_17624458 0.599 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase
chr19_+_34290653 0.596 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr9_-_62811592 0.593 ENSMUST00000034775.8
 Fem1b
feminization 1 homolog b (C. elegans)
chr7_+_12897800 0.558 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr11_+_67966442 0.536 ENSMUST00000021286.4
ENSMUST00000108675.1
 Stx8

syntaxin 8

chr2_+_163602331 0.464 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr13_+_73626886 0.460 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr10_-_127030789 0.452 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 0.8 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.7 GO:0042073 intraciliary transport(GO:0042073)
0.2 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.6 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.5 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 0.4 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.4 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.4 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.8 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.4 GO:0071817 MMXD complex(GO:0071817)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 1.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.8 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:0070402 NADPH binding(GO:0070402)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0005123 death receptor binding(GO:0005123)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)