Motif ID: Pax6

Z-value: 0.952


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105675478_105675527-0.651.2e-02Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 9.405 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_57118897 2.138 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57118981 1.931 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr2_-_162661075 1.330 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr8_-_57962564 1.309 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr17_-_51831884 0.842 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr5_-_142906702 0.833 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr11_-_95587691 0.808 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr5_+_90903864 0.725 ENSMUST00000075433.6
 Cxcl2
chemokine (C-X-C motif) ligand 2
chr18_+_37447641 0.722 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr2_-_75981967 0.709 ENSMUST00000099994.3
 Ttc30a1
tetratricopeptide repeat domain 30A1
chr3_+_65109343 0.651 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr17_-_17624458 0.599 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase
chr19_+_34290653 0.596 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr9_-_62811592 0.593 ENSMUST00000034775.8
 Fem1b
feminization 1 homolog b (C. elegans)
chr7_+_12897800 0.558 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr11_+_67966442 0.536 ENSMUST00000021286.4
ENSMUST00000108675.1
 Stx8

syntaxin 8

chr2_+_163602331 0.464 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr13_+_73626886 0.460 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr10_-_127030789 0.452 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr9_-_10904697 0.444 ENSMUST00000162484.1
 Cntn5
contactin 5
chr2_+_163602294 0.433 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr13_-_24937585 0.423 ENSMUST00000037615.6
 Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr7_+_75610038 0.418 ENSMUST00000125771.1
 Akap13
A kinase (PRKA) anchor protein 13
chr9_+_50775347 0.415 ENSMUST00000159576.1
 Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr5_-_18360384 0.413 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr12_-_45074457 0.402 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chrX_+_36795642 0.392 ENSMUST00000016463.3
 Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr1_-_38836090 0.390 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_+_155491353 0.349 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
 Gnb1


guanine nucleotide binding protein (G protein), beta 1


chr6_-_118780324 0.337 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr16_+_4968936 0.322 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr9_+_64179289 0.277 ENSMUST00000034965.6
 Snapc5
small nuclear RNA activating complex, polypeptide 5
chr13_-_113618549 0.266 ENSMUST00000109241.3
 Snx18
sorting nexin 18
chr1_+_156040884 0.264 ENSMUST00000060404.4
 Tor1aip2
torsin A interacting protein 2
chr2_+_105904629 0.250 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr18_-_34373313 0.244 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr1_+_156040909 0.235 ENSMUST00000065648.8
ENSMUST00000097526.2
 Tor1aip2

torsin A interacting protein 2

chr16_+_20498817 0.225 ENSMUST00000003320.6
 Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr16_-_22857514 0.223 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr4_+_85205417 0.220 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr7_+_141228766 0.208 ENSMUST00000106027.2
 Phrf1
PHD and ring finger domains 1
chr4_-_70410422 0.207 ENSMUST00000144099.1
 Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr8_+_95825353 0.203 ENSMUST00000074053.4
 Gm10094
predicted gene 10094
chr12_-_51829525 0.193 ENSMUST00000179265.1
ENSMUST00000042052.8
 Hectd1

HECT domain containing 1

chr11_-_6200411 0.184 ENSMUST00000066496.3
 Nudcd3
NudC domain containing 3
chr8_+_31150307 0.183 ENSMUST00000098842.2
 Tti2
TELO2 interacting protein 2
chr17_+_34604262 0.179 ENSMUST00000174041.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr6_-_88045190 0.174 ENSMUST00000113596.1
ENSMUST00000113600.3
 Rab7

RAB7, member RAS oncogene family

chr10_+_26229707 0.145 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr17_+_29614800 0.134 ENSMUST00000162588.1
 Rnf8
ring finger protein 8
chr15_+_6299797 0.120 ENSMUST00000159046.1
ENSMUST00000161040.1
 Dab2

disabled 2, mitogen-responsive phosphoprotein

chr10_+_94550852 0.114 ENSMUST00000148910.1
ENSMUST00000117460.1
 Tmcc3

transmembrane and coiled coil domains 3

chr13_-_66905322 0.112 ENSMUST00000021993.4
 Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr13_+_66905415 0.102 ENSMUST00000099412.2
 Gm10767
predicted gene 10767
chr3_+_98013503 0.092 ENSMUST00000079812.6
 Notch2
notch 2
chr4_-_139832920 0.087 ENSMUST00000174681.1
 Pax7
paired box gene 7
chr13_-_110280103 0.084 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr6_-_145048809 0.079 ENSMUST00000032402.5
 Bcat1
branched chain aminotransferase 1, cytosolic
chr13_-_32781716 0.075 ENSMUST00000134352.1
ENSMUST00000057428.4
 Mylk4

myosin light chain kinase family, member 4

chr1_-_180813534 0.075 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr4_-_3835595 0.073 ENSMUST00000138502.1
 Rps20
ribosomal protein S20
chr6_-_124741374 0.073 ENSMUST00000004389.5
 Grcc10
gene rich cluster, C10 gene
chr1_-_195131536 0.070 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr4_+_129820702 0.068 ENSMUST00000165853.1
 Ptp4a2
protein tyrosine phosphatase 4a2
chr10_-_127189981 0.064 ENSMUST00000019611.7
 Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr11_-_84870712 0.059 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr11_-_104550392 0.059 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr17_-_57059795 0.056 ENSMUST00000040280.7
 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr7_-_12775658 0.055 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr8_+_105860634 0.051 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr10_-_127030813 0.045 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr19_+_6400611 0.041 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr1_-_180813591 0.041 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr14_+_34170640 0.038 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr7_-_80901220 0.016 ENSMUST00000146402.1
ENSMUST00000026816.8
 Wdr73

WD repeat domain 73

chr6_-_60829826 0.015 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr11_+_60699758 0.008 ENSMUST00000108719.3
 Llgl1
lethal giant larvae homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.2 0.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.4 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.6 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0098912 smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.1 0.3 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.4 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:1990705 cholangiocyte proliferation(GO:1990705)
0.0 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 4.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.2 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.1 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.1 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.4 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.5 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.7 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.8 GO:0070688 MLL5-L complex(GO:0070688)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.4 GO:0071817 MMXD complex(GO:0071817)
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 0.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.8 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.7 GO:0070402 NADPH binding(GO:0070402)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.6 GO:0005123 death receptor binding(GO:0005123)
0.0 1.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)