Motif ID: Tfap2d

Z-value: 0.957


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.525.4e-02Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_92131494 3.374 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr11_-_32222233 3.340 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr8_-_105637350 2.836 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr2_+_26586607 2.334 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr5_-_71095765 1.882 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr2_+_167688915 1.761 ENSMUST00000070642.3
 Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
chr12_+_84009481 1.756 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr18_+_64340225 1.695 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr9_-_79718631 1.593 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr2_+_128126030 1.528 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
 Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr8_-_105637403 1.523 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr6_+_124996681 1.428 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr18_-_80986578 1.397 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr9_-_79718518 1.389 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr7_-_57509995 1.313 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr19_+_8929628 1.279 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr19_+_42147373 1.246 ENSMUST00000061111.9
 Marveld1
MARVEL (membrane-associating) domain containing 1
chr4_-_106464167 1.225 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr12_+_83987854 1.218 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr9_-_79718720 1.209 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 3.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 3.6 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 3.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.3 1.9 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.0 1.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.3 1.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.5 GO:0001907 killing by symbiont of host cells(GO:0001907) induction of programmed cell death(GO:0012502) disruption by symbiont of host cell(GO:0044004) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of fibroblast apoptotic process(GO:2000271)
0.4 1.4 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.1 1.4 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.4 1.3 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.4 1.2 GO:0002432 granuloma formation(GO:0002432)
0.2 1.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 1.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 1.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 1.2 GO:0008217 regulation of blood pressure(GO:0008217)
0.4 1.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 1.0 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 1.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 1.0 GO:0016082 synaptic vesicle priming(GO:0016082)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.2 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 3.2 GO:0000139 Golgi membrane(GO:0000139)
0.2 1.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6 1.8 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 1.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 1.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.3 1.0 GO:0035061 interchromatin granule(GO:0035061)
0.2 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.7 GO:0005827 polar microtubule(GO:0005827)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.1 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 3.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.9 GO:0005112 Notch binding(GO:0005112)
0.1 1.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0045502 dynein binding(GO:0045502)
0.4 1.2 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.1 GO:0048018 receptor agonist activity(GO:0048018)
0.2 1.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 0.9 GO:0004104 choline kinase activity(GO:0004103) cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 0.9 GO:0016917 GABA receptor activity(GO:0016917)
0.1 0.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.8 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)