Motif ID: Hoxa4
Z-value: 1.263
Transcription factors associated with Hoxa4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa4 | ENSMUSG00000000942.10 | Hoxa4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 8.6 | GO:0021893 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) |
1.7 | 5.0 | GO:2001139 | negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139) |
1.3 | 4.0 | GO:0072092 | ureteric bud invasion(GO:0072092) |
1.3 | 14.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
1.3 | 3.8 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
0.7 | 4.8 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
0.3 | 10.5 | GO:0007638 | mechanosensory behavior(GO:0007638) |
0.3 | 1.0 | GO:0048389 | BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) ureter urothelium development(GO:0072190) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
0.2 | 1.2 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
0.2 | 0.7 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.2 | 0.8 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
0.2 | 0.4 | GO:0032829 | regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) |
0.2 | 0.5 | GO:0003032 | detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005) |
0.2 | 2.9 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.2 | 0.5 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
0.2 | 1.8 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
0.2 | 2.0 | GO:0043084 | penile erection(GO:0043084) |
0.2 | 0.5 | GO:0097274 | urea homeostasis(GO:0097274) |
0.1 | 1.9 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
0.1 | 0.4 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) phosphate ion transmembrane transport(GO:0035435) |
0.1 | 0.4 | GO:0021759 | globus pallidus development(GO:0021759) |
0.1 | 2.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.1 | 0.5 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
0.1 | 0.5 | GO:0051697 | protein delipidation(GO:0051697) |
0.1 | 1.5 | GO:0006953 | acute-phase response(GO:0006953) |
0.1 | 0.4 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
0.1 | 0.7 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
0.1 | 0.8 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.1 | 1.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.4 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
0.1 | 1.1 | GO:0048664 | neuron fate determination(GO:0048664) |
0.1 | 0.5 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
0.1 | 0.4 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.1 | 0.6 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.1 | 1.0 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
0.1 | 1.6 | GO:0007614 | short-term memory(GO:0007614) |
0.1 | 0.3 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
0.1 | 0.5 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.1 | 0.4 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.1 | 0.1 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
0.1 | 0.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.1 | 1.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.1 | 6.4 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
0.0 | 1.7 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
0.0 | 0.8 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
0.0 | 1.2 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 1.0 | GO:0006907 | pinocytosis(GO:0006907) |
0.0 | 1.8 | GO:0030901 | midbrain development(GO:0030901) |
0.0 | 0.2 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
0.0 | 0.6 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.0 | 3.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.3 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
0.0 | 0.4 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.0 | 0.4 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
0.0 | 0.3 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
0.0 | 1.7 | GO:0008542 | visual learning(GO:0008542) |
0.0 | 0.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
0.0 | 0.6 | GO:0006089 | lactate metabolic process(GO:0006089) |
0.0 | 0.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.4 | GO:0051447 | negative regulation of meiotic cell cycle(GO:0051447) |
0.0 | 0.1 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.0 | 1.0 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.1 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
0.0 | 0.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.0 | 0.4 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
0.0 | 0.4 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.0 | 1.9 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
0.0 | 2.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
0.0 | 0.1 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
0.0 | 0.2 | GO:0046686 | response to cadmium ion(GO:0046686) |
0.0 | 0.3 | GO:0034389 | lipid particle organization(GO:0034389) |
0.0 | 1.2 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
0.0 | 0.2 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
0.0 | 0.1 | GO:0019287 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490) |
0.0 | 0.0 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
0.0 | 0.4 | GO:2001222 | regulation of neuron migration(GO:2001222) |
0.0 | 0.3 | GO:0030252 | growth hormone secretion(GO:0030252) |
0.0 | 0.1 | GO:0051775 | response to redox state(GO:0051775) |
0.0 | 0.0 | GO:0090526 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.0 | 0.6 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
0.0 | 0.9 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
0.0 | 0.1 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
0.0 | 0.4 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 5.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.6 | 1.7 | GO:0044299 | C-fiber(GO:0044299) |
0.2 | 1.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.1 | 0.6 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567) |
0.1 | 2.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.1 | 4.0 | GO:0005871 | kinesin complex(GO:0005871) |
0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 1.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.0 | 2.0 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 1.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.1 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
0.0 | 0.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.0 | 1.1 | GO:0031985 | Golgi cisterna(GO:0031985) |
0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 14.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
1.7 | 5.0 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.5 | 4.2 | GO:0050693 | LBD domain binding(GO:0050693) |
0.5 | 1.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.4 | 4.8 | GO:0038191 | neuropilin binding(GO:0038191) |
0.3 | 1.8 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.3 | 4.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.2 | 1.3 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.2 | 1.2 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.2 | 2.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.1 | 1.7 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 0.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.1 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.1 | 0.6 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.1 | 1.0 | GO:0039706 | co-receptor binding(GO:0039706) |
0.1 | 2.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 1.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.1 | 6.4 | GO:0002039 | p53 binding(GO:0002039) |
0.1 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.1 | 0.4 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.1 | 1.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.1 | 0.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.1 | 2.6 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.1 | 1.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 1.2 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 1.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.1 | 0.4 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
0.0 | 0.5 | GO:1990405 | protein antigen binding(GO:1990405) |
0.0 | 0.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.0 | 0.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.0 | 0.3 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.0 | 0.4 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.0 | 0.5 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
0.0 | 22.3 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
0.0 | 0.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
0.0 | 0.6 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
0.0 | 0.3 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.0 | 0.3 | GO:0052872 | 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014) |
0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.7 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.4 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.0 | 0.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 1.0 | GO:0097110 | scaffold protein binding(GO:0097110) |
0.0 | 0.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.0 | 0.4 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.0 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
0.0 | 0.5 | GO:0043531 | ADP binding(GO:0043531) |
0.0 | 0.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 0.3 | GO:0051059 | NF-kappaB binding(GO:0051059) |