Motif ID: Hoxa4

Z-value: 1.263


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 8.628 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_-_77519565 6.445 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr4_+_144892813 5.736 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr7_-_19699008 5.018 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr5_+_17574726 4.764 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_144893077 4.712 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_178529113 3.984 ENSMUST00000161017.1
 Kif26b
kinesin family member 26B
chr4_+_144893127 3.843 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_190170671 3.828 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr12_+_38780284 3.730 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 2.648 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_5218546 2.533 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr14_-_79771305 2.498 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr13_-_78196373 2.310 ENSMUST00000125176.2
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr5_+_137030275 1.969 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr15_+_32920723 1.871 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr18_+_37435602 1.864 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr2_+_170731807 1.842 ENSMUST00000029075.4
 Dok5
docking protein 5
chr1_+_19103022 1.792 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_5218516 1.770 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 14.1 GO:0042572 retinol metabolic process(GO:0042572)
0.3 10.5 GO:0007638 mechanosensory behavior(GO:0007638)
2.9 8.6 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 6.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
1.7 5.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.7 4.8 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.3 4.0 GO:0072092 ureteric bud invasion(GO:0072092)
1.3 3.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 2.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 2.6 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 2.0 GO:0043084 penile erection(GO:0043084)
0.1 1.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.9 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.2 1.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 1.8 GO:0030901 midbrain development(GO:0030901)
0.0 1.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.7 GO:0008542 visual learning(GO:0008542)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 4.0 GO:0005871 kinesin complex(GO:0005871)
0.1 2.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.0 GO:0030667 secretory granule membrane(GO:0030667)
0.6 1.7 GO:0044299 C-fiber(GO:0044299)
0.0 1.1 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.1 GO:0031985 Golgi cisterna(GO:0031985)
0.2 1.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.6 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
2.0 14.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 6.4 GO:0002039 p53 binding(GO:0002039)
1.7 5.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 4.8 GO:0038191 neuropilin binding(GO:0038191)
0.5 4.2 GO:0050693 LBD domain binding(GO:0050693)
0.3 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 2.6 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.5 1.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 1.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 1.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.2 GO:0032794 GTPase activating protein binding(GO:0032794)