Motif ID: Hic2

Z-value: 0.709


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.401.5e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_122697603 0.712 ENSMUST00000071235.4
 Gm10064
predicted gene 10064
chr6_+_88724828 0.623 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr4_+_154960915 0.564 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_172549581 0.555 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr7_-_103813913 0.529 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr12_+_85599388 0.520 ENSMUST00000050687.6
 Jdp2
Jun dimerization protein 2
chr2_-_26092149 0.464 ENSMUST00000114159.2
 Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chrY_+_897782 0.428 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr11_+_78324200 0.411 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chrX_+_93286499 0.404 ENSMUST00000046565.7
ENSMUST00000113947.2
 Arx

aristaless related homeobox

chr11_+_97030130 0.386 ENSMUST00000153482.1
 Scrn2
secernin 2
chr11_-_78165521 0.358 ENSMUST00000017530.3
 Traf4
TNF receptor associated factor 4
chr2_-_166713758 0.349 ENSMUST00000036719.5
 Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr16_-_76403673 0.343 ENSMUST00000052867.7
 Gm9843
predicted gene 9843
chr5_+_140607334 0.333 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_-_71963713 0.330 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr12_+_85599047 0.327 ENSMUST00000177587.1
 Jdp2
Jun dimerization protein 2
chr5_+_135887905 0.319 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr9_+_118478851 0.313 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr13_-_54055650 0.311 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.8 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 0.7 GO:0032796 uropod organization(GO:0032796)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 0.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 0.6 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.6 GO:0019086 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.1 0.6 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.2 0.5 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.5 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.5 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.4 GO:0048866 stem cell fate specification(GO:0048866)
0.1 0.4 GO:0072070 loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.1 0.4 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.4 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.4 GO:0015670 carbon dioxide transport(GO:0015670)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.2 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.6 GO:0019825 oxygen binding(GO:0019825)
0.1 0.6 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.1 0.5 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.1 0.4 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.4 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0 0.4 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)