Motif ID: Ep300

Z-value: 0.664


Transcription factors associated with Ep300:

Gene SymbolEntrez IDGene Name
Ep300 ENSMUSG00000055024.6 Ep300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ep300mm10_v2_chr15_+_81586206_815862500.704.9e-03Click!


Activity profile for motif Ep300.

activity profile for motif Ep300


Sorted Z-values histogram for motif Ep300

Sorted Z-values for motif Ep300



Network of associatons between targets according to the STRING database.



First level regulatory network of Ep300

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 2.851 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr11_+_98348404 2.366 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_103313806 1.738 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr2_-_57124003 1.663 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr6_-_136173492 1.318 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr7_+_96522342 1.121 ENSMUST00000129737.1
 Tenm4
teneurin transmembrane protein 4
chr15_-_13173607 1.089 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr19_+_23758819 1.046 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr1_-_21961581 1.042 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr10_-_127534540 1.007 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr13_-_29984219 0.933 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr10_-_63244135 0.891 ENSMUST00000054837.3
 1700120B22Rik
RIKEN cDNA 1700120B22 gene
chr4_+_136469755 0.853 ENSMUST00000170102.1
ENSMUST00000105849.2
ENSMUST00000129230.2
 Luzp1


leucine zipper protein 1


chr4_-_123527648 0.844 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr1_-_21961942 0.786 ENSMUST00000115300.1
 Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr17_+_35841668 0.769 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr12_-_80260356 0.748 ENSMUST00000021554.8
 Actn1
actinin, alpha 1
chr6_-_38876163 0.718 ENSMUST00000161779.1
 Hipk2
homeodomain interacting protein kinase 2
chr5_-_25100624 0.698 ENSMUST00000030784.7
 Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr4_+_123183456 0.696 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8 2.4 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.4 1.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 1.7 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.4 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.1 1.2 GO:0051639 actin filament network formation(GO:0051639)
0.3 1.1 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.2 1.1 GO:0001842 neural fold formation(GO:0001842)
0.1 1.0 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) motor neuron axon guidance(GO:0008045)
0.2 0.9 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.9 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.1 0.8 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.7 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.7 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.2 0.6 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.1 0.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.6 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.3 1.2 GO:0032127 dense core granule membrane(GO:0032127)
0.1 1.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.9 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.3 GO:0005816 spindle pole body(GO:0005816)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.8 2.4 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 1.3 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.2 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 0.8 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.7 GO:0046790 virion binding(GO:0046790)
0.1 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 0.6 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 0.6 GO:0008521 acetyl-CoA transporter activity(GO:0008521)
0.1 0.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)