Motif ID: Mtf1

Z-value: 1.107


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.039.1e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 18.323 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 9.876 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 7.188 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr1_+_135729147 2.838 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_167618246 2.442 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr6_-_39118211 2.357 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_+_119112793 1.993 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr11_+_63133068 1.956 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr10_+_77606571 1.537 ENSMUST00000099538.5
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr12_+_33957645 1.518 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1
chr9_-_112187898 1.489 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_-_4615647 1.459 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr3_+_107895821 1.428 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr11_+_63132569 1.423 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr3_+_107895916 1.413 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr19_-_4615453 1.343 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr10_+_17723220 1.214 ENSMUST00000038107.7
 Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr15_-_58214882 1.132 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr1_-_169531343 1.117 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr14_-_26170283 1.113 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr12_+_103532435 1.110 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr3_+_107896247 1.094 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr7_-_109865586 1.061 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
 Scube2


signal peptide, CUB domain, EGF-like 2


chr1_+_157412352 1.049 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr4_+_129985098 1.023 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr4_+_129984833 0.984 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr10_+_70245083 0.928 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr8_+_123373778 0.894 ENSMUST00000057934.3
ENSMUST00000108840.2
 Tcf25

transcription factor 25 (basic helix-loop-helix)

chr1_-_169531447 0.878 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr17_+_85620816 0.871 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr2_-_130664565 0.851 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr18_+_11839220 0.750 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr8_+_106210936 0.738 ENSMUST00000071592.5
 Prmt7
protein arginine N-methyltransferase 7
chr11_+_99047311 0.731 ENSMUST00000140772.1
 Igfbp4
insulin-like growth factor binding protein 4
chr17_-_56716788 0.731 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr5_-_34637203 0.692 ENSMUST00000114331.3
 Mfsd10
major facilitator superfamily domain containing 10
chr17_-_56626872 0.658 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr5_-_34637107 0.630 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
 Mfsd10



major facilitator superfamily domain containing 10



chr1_+_131867224 0.613 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr10_+_77606044 0.608 ENSMUST00000020501.8
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr8_-_106210924 0.583 ENSMUST00000035925.5
 Slc7a6os
solute carrier family 7, member 6 opposite strand
chr10_+_20952547 0.575 ENSMUST00000105525.4
 Ahi1
Abelson helper integration site 1
chr7_+_43607169 0.535 ENSMUST00000120935.1
ENSMUST00000127765.1
ENSMUST00000032661.7
 Zfp819


zinc finger protein 819


chr10_+_77606217 0.527 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr5_-_125341043 0.493 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr9_+_78175898 0.485 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr5_+_30869579 0.440 ENSMUST00000046349.7
 Tmem214
transmembrane protein 214
chr4_-_93335510 0.440 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr7_+_5056856 0.406 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr5_+_30869623 0.388 ENSMUST00000114716.1
 Tmem214
transmembrane protein 214
chr8_+_106211016 0.383 ENSMUST00000109297.1
 Prmt7
protein arginine N-methyltransferase 7
chr3_-_94412883 0.380 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr10_+_81136223 0.368 ENSMUST00000048128.8
 Zbtb7a
zinc finger and BTB domain containing 7a
chr1_+_128103297 0.367 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1
chr9_+_109832998 0.339 ENSMUST00000119376.1
ENSMUST00000122343.1
 Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr6_+_18848571 0.339 ENSMUST00000056398.8
 Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr1_-_166002591 0.317 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr8_-_70776650 0.312 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr19_-_4839286 0.309 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr18_-_84589491 0.256 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr2_-_91236967 0.255 ENSMUST00000028696.4
 Ddb2
damage specific DNA binding protein 2
chr5_-_123749393 0.226 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr5_-_123749371 0.200 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr15_-_83149307 0.173 ENSMUST00000100375.4
 Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr18_+_14424821 0.145 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr12_-_4592927 0.118 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr8_+_70905970 0.108 ENSMUST00000019405.2
 Map1s
microtubule-associated protein 1S
chr5_+_115506668 0.107 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr6_-_56923927 0.096 ENSMUST00000031793.5
 Nt5c3
5'-nucleotidase, cytosolic III
chr17_+_47688992 0.084 ENSMUST00000156118.1
 Frs3
fibroblast growth factor receptor substrate 3
chr12_+_24572276 0.075 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr2_-_91236877 0.074 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr15_+_100469034 0.066 ENSMUST00000037001.8
 Letmd1
LETM1 domain containing 1
chr1_+_75400070 0.039 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr4_-_43040279 0.037 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
 Fam214b


family with sequence similarity 214, member B


chr3_-_121815212 0.033 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr9_-_14381242 0.029 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr2_-_173119402 0.027 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 28.2 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.6 3.9 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.5 1.5 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.5 2.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.4 1.1 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 1.2 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.3 0.9 GO:0097402 neuroblast migration(GO:0097402)
0.3 1.3 GO:0042891 antibiotic transport(GO:0042891)
0.2 1.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 0.6 GO:0030862 regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.2 3.4 GO:0032060 bleb assembly(GO:0032060)
0.2 0.5 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.1 0.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 2.7 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 7.2 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 0.9 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 2.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 1.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 2.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.7 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 2.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.3 GO:0006183 GTP biosynthetic process(GO:0006183)
0.0 1.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.3 GO:0019430 removal of superoxide radicals(GO:0019430)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)
0.0 0.0 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0031262 Ndc80 complex(GO:0031262)
0.3 3.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.0 GO:0000800 lateral element(GO:0000800)
0.2 0.7 GO:0045098 type III intermediate filament(GO:0045098)
0.1 3.4 GO:0043218 compact myelin(GO:0043218)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 6.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.1 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 9.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 2.0 GO:0000150 recombinase activity(GO:0000150)
0.3 1.3 GO:0042895 antibiotic transporter activity(GO:0042895)
0.2 2.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 2.7 GO:0031386 protein tag(GO:0031386)
0.2 10.2 GO:0005507 copper ion binding(GO:0005507)
0.2 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 1.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 3.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.7 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 7.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 14.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)