Motif ID: Hoxc10

Z-value: 0.791


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25469742 4.726 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 4.002 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chrX_+_169685191 2.134 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr2_+_73271925 1.827 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr10_-_49783259 1.826 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr3_-_63851251 1.726 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr6_-_136875794 1.696 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr4_+_144893127 1.666 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr14_+_13454010 1.428 ENSMUST00000112656.2
 Synpr
synaptoporin
chr18_-_15063560 1.391 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr11_-_79504078 1.330 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr3_+_31902666 1.321 ENSMUST00000119970.1
ENSMUST00000178668.1
 Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chrM_+_3906 1.177 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr13_-_84064772 1.173 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr5_-_62766153 1.108 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_81936911 1.030 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr5_+_71699918 0.985 ENSMUST00000031122.7
 Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr15_+_81936753 0.950 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_91388079 0.876 ENSMUST00000181054.1
 A830009L08Rik
RIKEN cDNA A830009L08 gene
chr5_-_111761697 0.845 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr3_+_89266552 0.845 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr7_-_139582790 0.781 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr9_-_44799179 0.749 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr17_+_46681038 0.710 ENSMUST00000002845.6
 Mea1
male enhanced antigen 1
chr13_+_104287855 0.708 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr3_-_88410295 0.696 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr19_-_50678642 0.691 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr8_-_18741542 0.659 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr17_-_46680870 0.645 ENSMUST00000165007.1
ENSMUST00000071841.5
 Klhdc3

kelch domain containing 3

chr13_-_107890059 0.590 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr2_-_144527341 0.582 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr9_-_116175318 0.569 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr8_+_25720054 0.563 ENSMUST00000068916.8
ENSMUST00000139836.1
 Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr4_+_11758147 0.553 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr15_+_85510812 0.551 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr11_-_120549695 0.550 ENSMUST00000034913.4
 Fam195b
family with sequence similarity 195, member B
chr2_-_26122769 0.535 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr14_+_124005355 0.530 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr15_+_6422240 0.499 ENSMUST00000163082.1
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chr2_-_36104060 0.463 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr1_-_69108039 0.458 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr6_-_124965485 0.445 ENSMUST00000112439.2
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr3_+_134236483 0.421 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr6_-_124965403 0.410 ENSMUST00000129446.1
ENSMUST00000032220.8
 Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr1_-_45503282 0.406 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr17_-_90088343 0.396 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr13_-_41273977 0.386 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr2_+_130576170 0.377 ENSMUST00000028764.5
 Oxt
oxytocin
chr13_-_106847267 0.372 ENSMUST00000057427.4
 Lrrc70
leucine rich repeat containing 70
chr18_-_6490808 0.362 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr11_-_109472611 0.358 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr1_+_63176818 0.358 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr6_-_124965248 0.355 ENSMUST00000129976.1
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr8_-_47352348 0.351 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr15_-_58214882 0.335 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr17_-_91092715 0.334 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr3_-_49757257 0.321 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_+_50575273 0.281 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr1_-_163289214 0.272 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr3_+_32436151 0.270 ENSMUST00000029201.7
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr19_+_55894508 0.269 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr1_+_180111339 0.240 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr1_+_179960472 0.228 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr1_-_97761538 0.217 ENSMUST00000171129.1
 Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr4_-_133967296 0.209 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr17_-_78684262 0.208 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr14_+_54686171 0.192 ENSMUST00000038539.6
 1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr7_+_103550368 0.179 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr1_+_189728264 0.171 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr9_-_21287953 0.165 ENSMUST00000184326.1
ENSMUST00000038671.3
 Kri1

KRI1 homolog (S. cerevisiae)

chr1_+_17601893 0.160 ENSMUST00000088476.2
 Pi15
peptidase inhibitor 15
chr9_+_75775355 0.138 ENSMUST00000012281.7
 Bmp5
bone morphogenetic protein 5
chr1_-_63114516 0.120 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr1_-_63176653 0.110 ENSMUST00000027111.8
ENSMUST00000168099.2
 Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr1_+_159737510 0.100 ENSMUST00000111669.3
 Tnr
tenascin R
chr1_+_107511489 0.099 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr16_-_89508313 0.093 ENSMUST00000056118.2
 Krtap7-1
keratin associated protein 7-1
chr15_+_21111452 0.093 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr5_-_62765618 0.093 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_33824346 0.091 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
 Rps28




ribosomal protein S28




chr8_+_83666827 0.089 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chrX_+_56447965 0.075 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr11_-_97700327 0.058 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr7_-_30612731 0.048 ENSMUST00000006476.4
 Upk1a
uroplakin 1A
chr4_-_42661893 0.047 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr1_+_137928100 0.044 ENSMUST00000054333.2
 A130050O07Rik
RIKEN cDNA A130050O07 gene
chr8_-_94012558 0.034 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr4_-_129578535 0.019 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr15_+_16778101 0.014 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr1_+_58646608 0.011 ENSMUST00000081455.4
 Gm10068
predicted gene 10068
chr17_+_27839974 0.003 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr3_-_146770218 0.001 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 0.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 0.6 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 1.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.3 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.6 GO:0003430 tolerance induction to self antigen(GO:0002513) growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0042713 negative regulation of urine volume(GO:0035811) sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.1 0.3 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.8 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.5 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.3 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.5 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 1.2 GO:0010388 cullin deneddylation(GO:0010388)
0.1 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.5 GO:0032196 transposition(GO:0032196)
0.1 1.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.1 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.1 GO:0006407 rRNA export from nucleus(GO:0006407)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097)
0.0 0.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 1.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.7 GO:0035904 aorta development(GO:0035904)
0.0 1.8 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 0.8 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 7.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0070469 respiratory chain(GO:0070469)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 1.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.6 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.8 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)